An important CT-characteristic at a diagnostic of liver tumors is the determination of its vascularity. To study the characteristics of blood tissue of hepatocellular carcinoma (HCC) with different degrees of differentiation by CT. The work is based on the clinical and morphological comparisons performed in 55 patients (34 men and 21 women aged 15-83 years) with hepatocellular carcinoma (HCC) without accompanying liver cirrhosis. In the preoperative stage all patients was carried spiral computed tomography (CT) with bolus contrast enhancement (on the four phases of the study). Was evaluated parameters of CT density and degree of nodes HCC vascularization. Morphologic study of histological preparations of operation material from 16 patients was diagnosed high-differentiated, 33 - moderately differentiated, and 6 - poorly differentiated HCC. At the immunohistochemical preparations with reaction to CD34 was determined by the number and the total cross-sectional area of vessels in sight of HCC tissue. The maximum values of CT density in the arterial phase were observed at the nodes moderately differentiated HCC. In the venous phase the greatest values of density as well as the venous increase was registered in high-differentiated HCC. The most vascularised (hypervascular) tumor is high-differentiated HCC, and the least vascularized - poorly differentiated HCC by CT. At morphometric study of the maximum values of the number and the total cross-sectional area of the blood vessels are installed in high-differentiated HCC tissues, the minimum - in the tissue of low-grade HCC. CT with bolus contrast enhancement allows studying the characteristics of blood supply of HCC varying degrees of differentiation. Determine the true measure of total CT-vascularization of the tumor tissue must be done with consideration of the increase concentration difference coefficient (ICDC).
| Published in | American Journal of Clinical and Experimental Medicine (Volume 3, Issue 1) |
| DOI | 10.11648/j.ajcem.20150301.13 |
| Page(s) | 24-31 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2015. Published by Science Publishing Group |
Hepatocellular Carcinoma, Histological Differentiation, Computed Tomography, Contrast Enhancement, Vascularity
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APA Style
Ulyana N. Tumanova, Grigoriy G. Karmazanovsky, Alexander I. Shchyogolev. (2015). Computed Tomography Assessment of the Vascularization Degree of Hepatocellular Carcinoma in the Noncirrhotic Liver. American Journal of Clinical and Experimental Medicine, 3(1), 24-31. https://doi.org/10.11648/j.ajcem.20150301.13
ACS Style
Ulyana N. Tumanova; Grigoriy G. Karmazanovsky; Alexander I. Shchyogolev. Computed Tomography Assessment of the Vascularization Degree of Hepatocellular Carcinoma in the Noncirrhotic Liver. Am. J. Clin. Exp. Med. 2015, 3(1), 24-31. doi: 10.11648/j.ajcem.20150301.13
AMA Style
Ulyana N. Tumanova, Grigoriy G. Karmazanovsky, Alexander I. Shchyogolev. Computed Tomography Assessment of the Vascularization Degree of Hepatocellular Carcinoma in the Noncirrhotic Liver. Am J Clin Exp Med. 2015;3(1):24-31. doi: 10.11648/j.ajcem.20150301.13
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Download@article{10.11648/j.ajcem.20150301.13,
author = {Ulyana N. Tumanova and Grigoriy G. Karmazanovsky and Alexander I. Shchyogolev},
title = {Computed Tomography Assessment of the Vascularization Degree of Hepatocellular Carcinoma in the Noncirrhotic Liver},
journal = {American Journal of Clinical and Experimental Medicine},
volume = {3},
number = {1},
pages = {24-31},
doi = {10.11648/j.ajcem.20150301.13},
url = {https://doi.org/10.11648/j.ajcem.20150301.13},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajcem.20150301.13},
abstract = {An important CT-characteristic at a diagnostic of liver tumors is the determination of its vascularity. To study the characteristics of blood tissue of hepatocellular carcinoma (HCC) with different degrees of differentiation by CT. The work is based on the clinical and morphological comparisons performed in 55 patients (34 men and 21 women aged 15-83 years) with hepatocellular carcinoma (HCC) without accompanying liver cirrhosis. In the preoperative stage all patients was carried spiral computed tomography (CT) with bolus contrast enhancement (on the four phases of the study). Was evaluated parameters of CT density and degree of nodes HCC vascularization. Morphologic study of histological preparations of operation material from 16 patients was diagnosed high-differentiated, 33 - moderately differentiated, and 6 - poorly differentiated HCC. At the immunohistochemical preparations with reaction to CD34 was determined by the number and the total cross-sectional area of vessels in sight of HCC tissue. The maximum values of CT density in the arterial phase were observed at the nodes moderately differentiated HCC. In the venous phase the greatest values of density as well as the venous increase was registered in high-differentiated HCC. The most vascularised (hypervascular) tumor is high-differentiated HCC, and the least vascularized - poorly differentiated HCC by CT. At morphometric study of the maximum values of the number and the total cross-sectional area of the blood vessels are installed in high-differentiated HCC tissues, the minimum - in the tissue of low-grade HCC. CT with bolus contrast enhancement allows studying the characteristics of blood supply of HCC varying degrees of differentiation. Determine the true measure of total CT-vascularization of the tumor tissue must be done with consideration of the increase concentration difference coefficient (ICDC).},
year = {2015}
}
TY - JOUR T1 - Computed Tomography Assessment of the Vascularization Degree of Hepatocellular Carcinoma in the Noncirrhotic Liver AU - Ulyana N. Tumanova AU - Grigoriy G. Karmazanovsky AU - Alexander I. Shchyogolev Y1 - 2015/01/28 PY - 2015 N1 - https://doi.org/10.11648/j.ajcem.20150301.13 DO - 10.11648/j.ajcem.20150301.13 T2 - American Journal of Clinical and Experimental Medicine JF - American Journal of Clinical and Experimental Medicine JO - American Journal of Clinical and Experimental Medicine SP - 24 EP - 31 PB - Science Publishing Group SN - 2330-8133 UR - https://doi.org/10.11648/j.ajcem.20150301.13 AB - An important CT-characteristic at a diagnostic of liver tumors is the determination of its vascularity. To study the characteristics of blood tissue of hepatocellular carcinoma (HCC) with different degrees of differentiation by CT. The work is based on the clinical and morphological comparisons performed in 55 patients (34 men and 21 women aged 15-83 years) with hepatocellular carcinoma (HCC) without accompanying liver cirrhosis. In the preoperative stage all patients was carried spiral computed tomography (CT) with bolus contrast enhancement (on the four phases of the study). Was evaluated parameters of CT density and degree of nodes HCC vascularization. Morphologic study of histological preparations of operation material from 16 patients was diagnosed high-differentiated, 33 - moderately differentiated, and 6 - poorly differentiated HCC. At the immunohistochemical preparations with reaction to CD34 was determined by the number and the total cross-sectional area of vessels in sight of HCC tissue. The maximum values of CT density in the arterial phase were observed at the nodes moderately differentiated HCC. In the venous phase the greatest values of density as well as the venous increase was registered in high-differentiated HCC. The most vascularised (hypervascular) tumor is high-differentiated HCC, and the least vascularized - poorly differentiated HCC by CT. At morphometric study of the maximum values of the number and the total cross-sectional area of the blood vessels are installed in high-differentiated HCC tissues, the minimum - in the tissue of low-grade HCC. CT with bolus contrast enhancement allows studying the characteristics of blood supply of HCC varying degrees of differentiation. Determine the true measure of total CT-vascularization of the tumor tissue must be done with consideration of the increase concentration difference coefficient (ICDC). VL - 3 IS - 1 ER -
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