Mycobacterium tuberculosis (Mtb) infects approximately one third of world population. Many cytokines are produced during tuberculosis, with predominance of Th1 cytokines during the early stage and Th2 cytokines in the later stages of the infection. Most studies on cytokines during TB are from ‘in vitro’-stimulated lymphoid cells with few reports on in vivo plasma levels. The high expression of IL-4 has been implicated as a virulence factor. In the present study we examined the level of IL-4 in the serum of active tuberculosis in new cases, during anti-tubercular therapy and MDR cases. This Study was conducted at Department Of Microbiology, JNMC, AMU, Aligarh. A total 76 blood samples of Pulmonary & Extra-Pulmonary tuberculosis patients were tested by ELISA (Diaclone France) along with 10 healthy controls. The test was carried out according to the manufacturer instructions. O.D. was taken at 450 nm. There was no stastical difference in age and sex in our study. The level of IL-4 show significant changes in MDR TB cases (P<0.05) but not significant during the anti-tubercular therapy (ATT) and new TB cases (P>0.05). An understanding of the development of the cellular immune response may lead to insight into pathogenesis and novel therapies for TB. Further studies are needed to address the role of cytokines in immunity to TB under natural conditions.
| Published in | American Journal of Clinical and Experimental Medicine (Volume 3, Issue 1) |
| DOI | 10.11648/j.ajcem.20150301.17 |
| Page(s) | 48-51 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2015. Published by Science Publishing Group |
MDR TB, IL-4, Cytokines
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APA Style
Nazish Fatima, Mohammad Shameem, Nabeela, Parvez A. Khan, H. M. Khan. (2015). Correlation of Serum IL-4 Levels in New and MDR Tuberculosis Patients. American Journal of Clinical and Experimental Medicine, 3(1), 48-51. https://doi.org/10.11648/j.ajcem.20150301.17
ACS Style
Nazish Fatima; Mohammad Shameem; Nabeela; Parvez A. Khan; H. M. Khan. Correlation of Serum IL-4 Levels in New and MDR Tuberculosis Patients. Am. J. Clin. Exp. Med. 2015, 3(1), 48-51. doi: 10.11648/j.ajcem.20150301.17
AMA Style
Nazish Fatima, Mohammad Shameem, Nabeela, Parvez A. Khan, H. M. Khan. Correlation of Serum IL-4 Levels in New and MDR Tuberculosis Patients. Am J Clin Exp Med. 2015;3(1):48-51. doi: 10.11648/j.ajcem.20150301.17
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Download@article{10.11648/j.ajcem.20150301.17,
author = {Nazish Fatima and Mohammad Shameem and Nabeela and Parvez A. Khan and H. M. Khan},
title = {Correlation of Serum IL-4 Levels in New and MDR Tuberculosis Patients},
journal = {American Journal of Clinical and Experimental Medicine},
volume = {3},
number = {1},
pages = {48-51},
doi = {10.11648/j.ajcem.20150301.17},
url = {https://doi.org/10.11648/j.ajcem.20150301.17},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajcem.20150301.17},
abstract = {Mycobacterium tuberculosis (Mtb) infects approximately one third of world population. Many cytokines are produced during tuberculosis, with predominance of Th1 cytokines during the early stage and Th2 cytokines in the later stages of the infection. Most studies on cytokines during TB are from ‘in vitro’-stimulated lymphoid cells with few reports on in vivo plasma levels. The high expression of IL-4 has been implicated as a virulence factor. In the present study we examined the level of IL-4 in the serum of active tuberculosis in new cases, during anti-tubercular therapy and MDR cases. This Study was conducted at Department Of Microbiology, JNMC, AMU, Aligarh. A total 76 blood samples of Pulmonary & Extra-Pulmonary tuberculosis patients were tested by ELISA (Diaclone France) along with 10 healthy controls. The test was carried out according to the manufacturer instructions. O.D. was taken at 450 nm. There was no stastical difference in age and sex in our study. The level of IL-4 show significant changes in MDR TB cases (P0.05). An understanding of the development of the cellular immune response may lead to insight into pathogenesis and novel therapies for TB. Further studies are needed to address the role of cytokines in immunity to TB under natural conditions.},
year = {2015}
}
TY - JOUR T1 - Correlation of Serum IL-4 Levels in New and MDR Tuberculosis Patients AU - Nazish Fatima AU - Mohammad Shameem AU - Nabeela AU - Parvez A. Khan AU - H. M. Khan Y1 - 2015/02/06 PY - 2015 N1 - https://doi.org/10.11648/j.ajcem.20150301.17 DO - 10.11648/j.ajcem.20150301.17 T2 - American Journal of Clinical and Experimental Medicine JF - American Journal of Clinical and Experimental Medicine JO - American Journal of Clinical and Experimental Medicine SP - 48 EP - 51 PB - Science Publishing Group SN - 2330-8133 UR - https://doi.org/10.11648/j.ajcem.20150301.17 AB - Mycobacterium tuberculosis (Mtb) infects approximately one third of world population. Many cytokines are produced during tuberculosis, with predominance of Th1 cytokines during the early stage and Th2 cytokines in the later stages of the infection. Most studies on cytokines during TB are from ‘in vitro’-stimulated lymphoid cells with few reports on in vivo plasma levels. The high expression of IL-4 has been implicated as a virulence factor. In the present study we examined the level of IL-4 in the serum of active tuberculosis in new cases, during anti-tubercular therapy and MDR cases. This Study was conducted at Department Of Microbiology, JNMC, AMU, Aligarh. A total 76 blood samples of Pulmonary & Extra-Pulmonary tuberculosis patients were tested by ELISA (Diaclone France) along with 10 healthy controls. The test was carried out according to the manufacturer instructions. O.D. was taken at 450 nm. There was no stastical difference in age and sex in our study. The level of IL-4 show significant changes in MDR TB cases (P0.05). An understanding of the development of the cellular immune response may lead to insight into pathogenesis and novel therapies for TB. Further studies are needed to address the role of cytokines in immunity to TB under natural conditions. VL - 3 IS - 1 ER -
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