Pulmonary histiocytic sarcoma is a rare, but highly malignant disease. Its low incidence imposes significant difficulties on physicians confronted with affected patients. The reported patient is a 24-year old male with histiocytic sarcoma of the lung. Left lower lobectomy was performed. Histologically, tumor cells had no features of carcinoma. Several entities were raised as differentials: large B or T cell lymphomas, metastatic melanoma, sarcoma, undifferentiated carcinoma, NK cell lymphoma. Immunohistochemically, melanoma, carcinoma, undifferentiated epithelioid sarcoma and also different types of lymphoma were excluded. Therefore, tumors of the histiocytic and dendritic cell lineage had to be considered. Tumors of the dendritic cell lineage were also immunohistochemically excluded, leaving histiocytic sarcoma by exclusion. The patient was followed for six years and six months, with no signs of recurrence of the tumor. Histiocytic sarcomas are tumors of uncertain behavior, with some progressing quickly, and others having a much slower course. As these tumors are rare, there is not much information, although a low number of mitosis might point to a less aggressive course. In the present patient with an unifocal disease, surgical excision was sufficient, without adjuvant radiotherapy and chemotherapy.
| Published in | American Journal of Internal Medicine (Volume 5, Issue 5) |
| DOI | 10.11648/j.ajim.20170505.16 |
| Page(s) | 91-94 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2017. Published by Science Publishing Group |
Neoplasms, Histiocytic Sarcoma, Lung, Immunohistochemistry, Surgical Treatment
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APA Style
Veljko Flego, Helmut Popper, Darian Volaric, Ljiljana Bulat-Kardum. (2017). Pulmonary Histiocytic Sarcoma: A Case Report and Literature Review. American Journal of Internal Medicine, 5(5), 91-94. https://doi.org/10.11648/j.ajim.20170505.16
ACS Style
Veljko Flego; Helmut Popper; Darian Volaric; Ljiljana Bulat-Kardum. Pulmonary Histiocytic Sarcoma: A Case Report and Literature Review. Am. J. Intern. Med. 2017, 5(5), 91-94. doi: 10.11648/j.ajim.20170505.16
AMA Style
Veljko Flego, Helmut Popper, Darian Volaric, Ljiljana Bulat-Kardum. Pulmonary Histiocytic Sarcoma: A Case Report and Literature Review. Am J Intern Med. 2017;5(5):91-94. doi: 10.11648/j.ajim.20170505.16
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Download@article{10.11648/j.ajim.20170505.16,
author = {Veljko Flego and Helmut Popper and Darian Volaric and Ljiljana Bulat-Kardum},
title = {Pulmonary Histiocytic Sarcoma: A Case Report and Literature Review},
journal = {American Journal of Internal Medicine},
volume = {5},
number = {5},
pages = {91-94},
doi = {10.11648/j.ajim.20170505.16},
url = {https://doi.org/10.11648/j.ajim.20170505.16},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajim.20170505.16},
abstract = {Pulmonary histiocytic sarcoma is a rare, but highly malignant disease. Its low incidence imposes significant difficulties on physicians confronted with affected patients. The reported patient is a 24-year old male with histiocytic sarcoma of the lung. Left lower lobectomy was performed. Histologically, tumor cells had no features of carcinoma. Several entities were raised as differentials: large B or T cell lymphomas, metastatic melanoma, sarcoma, undifferentiated carcinoma, NK cell lymphoma. Immunohistochemically, melanoma, carcinoma, undifferentiated epithelioid sarcoma and also different types of lymphoma were excluded. Therefore, tumors of the histiocytic and dendritic cell lineage had to be considered. Tumors of the dendritic cell lineage were also immunohistochemically excluded, leaving histiocytic sarcoma by exclusion. The patient was followed for six years and six months, with no signs of recurrence of the tumor. Histiocytic sarcomas are tumors of uncertain behavior, with some progressing quickly, and others having a much slower course. As these tumors are rare, there is not much information, although a low number of mitosis might point to a less aggressive course. In the present patient with an unifocal disease, surgical excision was sufficient, without adjuvant radiotherapy and chemotherapy.},
year = {2017}
}
TY - JOUR T1 - Pulmonary Histiocytic Sarcoma: A Case Report and Literature Review AU - Veljko Flego AU - Helmut Popper AU - Darian Volaric AU - Ljiljana Bulat-Kardum Y1 - 2017/10/24 PY - 2017 N1 - https://doi.org/10.11648/j.ajim.20170505.16 DO - 10.11648/j.ajim.20170505.16 T2 - American Journal of Internal Medicine JF - American Journal of Internal Medicine JO - American Journal of Internal Medicine SP - 91 EP - 94 PB - Science Publishing Group SN - 2330-4324 UR - https://doi.org/10.11648/j.ajim.20170505.16 AB - Pulmonary histiocytic sarcoma is a rare, but highly malignant disease. Its low incidence imposes significant difficulties on physicians confronted with affected patients. The reported patient is a 24-year old male with histiocytic sarcoma of the lung. Left lower lobectomy was performed. Histologically, tumor cells had no features of carcinoma. Several entities were raised as differentials: large B or T cell lymphomas, metastatic melanoma, sarcoma, undifferentiated carcinoma, NK cell lymphoma. Immunohistochemically, melanoma, carcinoma, undifferentiated epithelioid sarcoma and also different types of lymphoma were excluded. Therefore, tumors of the histiocytic and dendritic cell lineage had to be considered. Tumors of the dendritic cell lineage were also immunohistochemically excluded, leaving histiocytic sarcoma by exclusion. The patient was followed for six years and six months, with no signs of recurrence of the tumor. Histiocytic sarcomas are tumors of uncertain behavior, with some progressing quickly, and others having a much slower course. As these tumors are rare, there is not much information, although a low number of mitosis might point to a less aggressive course. In the present patient with an unifocal disease, surgical excision was sufficient, without adjuvant radiotherapy and chemotherapy. VL - 5 IS - 5 ER -
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