| Peer-Reviewed

Occurrence of Different Types of Endometrial Carcinoma in Hysterectomy Specimens from Different Hospitals in Karachi, Pakistan

Received: 1 April 2015     Accepted: 15 April 2015     Published: 30 April 2015
Views:       Downloads:
Abstract

Introduction: Endometrial carcinoma can occur due to different causes. It is associated with other diseases like endometrial hyperplasia, obesity, diabetes, early menarche and late menopause. Histological and histochemical procedures, help in diagnosis of different types of endometrial carcinoma. Objectives: To identify predominant histological and histochemical type of endometrial carcinoma from hysterectomy specimens collected from different tertiary care hospitals of Karachi, Pakistan. Methodology: Slides / paraffin blocks of endometrial biopsies of hysterectomy specimens were taken, from 1st January 2008 to 31st December 2012. Results: In present study, total 226 hysterectomy cases were received in which 70 (30.97%) cases of different type of endometrial carcinoma were studied. The maximum 46 (65.71%) cases were of endometroid secretory adenocarcinoma. 16 (22.90%) cases, of Endometroid pappilary carcinoma. 3 (4.30%) cases of ciliated adenocarcinoma and 1 (1.42%) case villoglandular endometrial cancer. Conclusion: Increased tendency of endometroid secretory adenocarcinoma of endometrium as 46 (65.71%) cases out of 70 cases.

Published in American Journal of Life Sciences (Volume 3, Issue 3)
DOI 10.11648/j.ajls.20150303.13
Page(s) 143-146
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2015. Published by Science Publishing Group

Keywords

Endometrial, Clear Cell, Endometroid, Mixed Type Carcinoma, Mucinous Adenocarcinoma, Serous Adenocarcinoma, Signet Ring Cell Carcinoma

References
[1] Bhurgri Y, Nazir K, Shaheen Y, et al. Pathoepidemiology of cancer corpus uteri in Karachi South “1995–1997” Asian Pac J Cancer Prev. 2007;8:489–494.
[2] Pecorelli S, Favalli G, Zigliani L, Odicino F. Cancer in women. Int J Gynaecol Obstet. 2003;82:369–379.
[3] Kurman RJ, Kamiriski PF, Norris HJ. The behavior of endometrial hyperplasia; A long term study of untreated endometrial hyperplasia in 170 patients. Cancer 1985;56:403–12.
[4] Richard Cote, Saul Suster, Lawrence Weiss, Noel Weidner (Editor) (2002). Modern Surgical Pathology (2 Volume Set). London: W B Saunders.
[5] Kurman RJ, Kaminski PF, Norris HJ (1985). "The behavior of endometrial hyperplasia. A long-term study of "untreated" hyperplasia in 170 patients". Cancer 56 (2): pp.403–12.
[6] Friedenreich, CM; Neilson, HK, Lynch, BM (2010 Sep). "State of the epidemiological evidence on physical activity and cancer prevention.". European journal of cancer (Oxford, England: 1990) 46 (14):2593 604. doi:10.1016/j.ejca.2010.07.028.
[7] Yamazawa, K; Shimada, H; Hirai, M; Hirashiki, K; Ochiai, T; Ishikura, H; Shozu, M; Isaka, K (2007). "Serum p53 antibody as a diagnostic marker of high-risk endoametrial cancer.". American journal of obstetrics and gynecology 197 (5):05.e17.doi:10.1016/j.ajog.2007.04.033.
[8] Reeler A, Qiao Y, Dare L, et al. Women’s cancers in developing countries: from research to an integrated health systems approach. Asian Pac J Cancer Prev. 2009;10:519–526.
[9] Salazar-Martínez E, Lazcano-Ponce EC, Lira-Lira GG, et al. Case-control study of diabetes, obesity, physical activity and risk of endometrial cancer among Mexican women. Cancer Causes Control. 2000;11:707–711.
[10] Creasman WT. Endometrial Carcinoma. eMedicine Specialities> Obstetrics and Gynaecology> Gyncologic Oncology. Updated July 2007.
[11] Tavassoli F, Devilee P. World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of the Breast and Female Genital Organs. Lyon: IARC Press, 2003.
[12] Richard Cote, Saul Suster, Lawrence Weiss, Noel Weidner (Editor) (2002). Modern Surgical Pathology (2 Volume Set). London: W B Saunders.
[13] Anderson MC, Robboy SJ, Russell P, Morse A: Endometrial carcinoma. In Pathology of the female reproductive tract. Edited by Robboy SJ, Anderson MC, Russell P. London, Churchill Livingston; 2002:331-359.
[14] Lax SF, Pizer ES, Ronnett BM, Kurman RJ: Comparison of estrogen and progesterone receptor, Ki-67, and p53 immunoreactivity in uterine endometrioid carcinoma and endometrioid carcinoma with squamous, mucinous, secretory, and ciliated cell differentiation.Hum athol 1998, 29:924-931.
[15] Berek JS, Hacker NF, eds. Practical gynecologic oncology. 2d ed. Baltimore: Williams & Wilkins, 1994:285–326.
[16] DiCristofano A, Ellenson LH: Endometrial carcinoma. Annual Review of Pathology: Mechanisms of Disease, Vol. 2:57 , 2007. [A comprehensive discussion of pathogenesis.]
[17] Jemal A, tiwari RC, Murray T, Ghafoor A, Ward E, Thun MJ. Cancer statistics, 2004. CA Cancer J Clin 2004; 54: 8-29.
[18] Walsh C, Holschneider C, Hoang Y et al. Co-existing ovarian malgnancy in young women with endometrial cancer. Obstetrics and Gynaecology 2005; 106: 693-9.
[19] Mackenzie I.Z, Bibby J,G. “Critical assessment of dilatation and curettage on 1029 women”. Lancet 1978; 566-9.
[20] Wernli KJ, Ray RM, Gao DL, et al. Occupational risk factors for endometrial cancer among textile workers in Shanghai, China. Am J Ind Med. 2008;51:673–679.
[21] A. Jemal, R. Siegel, J. Xu, and E. Ward, “Cancer statistics, 2010,” CA: A Cancer Journal for Clinicians, vol. 60, no. 5, pp. 277–300, 2010.
[22] Parkin DM, Whelan SL, Ferlay J, et al., editors. Cancer Incidence in Five Continents. Vol. VIII. Geneva: World Health Organization; 2007. (International Agency for Research on Cancer Publication No. 155).
[23] Leuw WJ, Dierssen J, Varen HF et al. Prediction of a mismatch repair gene defect by micro satellite instability and immunohistochemical analysis in endometrial - from HNPCE patients J Pathal 2000, 192-328.
[24] T. P. Boren and D. S. Miller, “Should all patients with serous and clear cell endometrial carcinoma receive adjuvant chemotherapy?” Women's Health, vol. 6, no. 6, pp. 789–795, 2010.
Cite This Article
  • APA Style

    Izhar Fatima, Muhammad Noman Rashid, Farha Ahmed, Ali Muhammad Soomro. (2015). Occurrence of Different Types of Endometrial Carcinoma in Hysterectomy Specimens from Different Hospitals in Karachi, Pakistan. American Journal of Life Sciences, 3(3), 143-146. https://doi.org/10.11648/j.ajls.20150303.13

    Copy | Download

    ACS Style

    Izhar Fatima; Muhammad Noman Rashid; Farha Ahmed; Ali Muhammad Soomro. Occurrence of Different Types of Endometrial Carcinoma in Hysterectomy Specimens from Different Hospitals in Karachi, Pakistan. Am. J. Life Sci. 2015, 3(3), 143-146. doi: 10.11648/j.ajls.20150303.13

    Copy | Download

    AMA Style

    Izhar Fatima, Muhammad Noman Rashid, Farha Ahmed, Ali Muhammad Soomro. Occurrence of Different Types of Endometrial Carcinoma in Hysterectomy Specimens from Different Hospitals in Karachi, Pakistan. Am J Life Sci. 2015;3(3):143-146. doi: 10.11648/j.ajls.20150303.13

    Copy | Download

  • @article{10.11648/j.ajls.20150303.13,
      author = {Izhar Fatima and Muhammad Noman Rashid and Farha Ahmed and Ali Muhammad Soomro},
      title = {Occurrence of Different Types of Endometrial Carcinoma in Hysterectomy Specimens from Different Hospitals in Karachi, Pakistan},
      journal = {American Journal of Life Sciences},
      volume = {3},
      number = {3},
      pages = {143-146},
      doi = {10.11648/j.ajls.20150303.13},
      url = {https://doi.org/10.11648/j.ajls.20150303.13},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajls.20150303.13},
      abstract = {Introduction: Endometrial carcinoma can occur due to different causes. It is associated with other diseases like endometrial hyperplasia, obesity, diabetes, early menarche and late menopause. Histological and histochemical procedures, help in diagnosis of different types of endometrial carcinoma. Objectives: To identify predominant histological and histochemical type of endometrial carcinoma from hysterectomy specimens collected from different tertiary care hospitals of Karachi, Pakistan. Methodology: Slides / paraffin blocks of endometrial biopsies of hysterectomy specimens were taken, from 1st January 2008 to 31st December 2012. Results: In present study, total 226 hysterectomy cases were received in which 70 (30.97%) cases of different type of endometrial carcinoma were studied. The maximum 46 (65.71%) cases were of endometroid secretory adenocarcinoma. 16 (22.90%) cases, of Endometroid pappilary carcinoma. 3 (4.30%) cases of ciliated adenocarcinoma and 1 (1.42%) case villoglandular endometrial cancer. Conclusion: Increased tendency of endometroid secretory adenocarcinoma of endometrium as 46 (65.71%) cases out of 70 cases.},
     year = {2015}
    }
    

    Copy | Download

  • TY  - JOUR
    T1  - Occurrence of Different Types of Endometrial Carcinoma in Hysterectomy Specimens from Different Hospitals in Karachi, Pakistan
    AU  - Izhar Fatima
    AU  - Muhammad Noman Rashid
    AU  - Farha Ahmed
    AU  - Ali Muhammad Soomro
    Y1  - 2015/04/30
    PY  - 2015
    N1  - https://doi.org/10.11648/j.ajls.20150303.13
    DO  - 10.11648/j.ajls.20150303.13
    T2  - American Journal of Life Sciences
    JF  - American Journal of Life Sciences
    JO  - American Journal of Life Sciences
    SP  - 143
    EP  - 146
    PB  - Science Publishing Group
    SN  - 2328-5737
    UR  - https://doi.org/10.11648/j.ajls.20150303.13
    AB  - Introduction: Endometrial carcinoma can occur due to different causes. It is associated with other diseases like endometrial hyperplasia, obesity, diabetes, early menarche and late menopause. Histological and histochemical procedures, help in diagnosis of different types of endometrial carcinoma. Objectives: To identify predominant histological and histochemical type of endometrial carcinoma from hysterectomy specimens collected from different tertiary care hospitals of Karachi, Pakistan. Methodology: Slides / paraffin blocks of endometrial biopsies of hysterectomy specimens were taken, from 1st January 2008 to 31st December 2012. Results: In present study, total 226 hysterectomy cases were received in which 70 (30.97%) cases of different type of endometrial carcinoma were studied. The maximum 46 (65.71%) cases were of endometroid secretory adenocarcinoma. 16 (22.90%) cases, of Endometroid pappilary carcinoma. 3 (4.30%) cases of ciliated adenocarcinoma and 1 (1.42%) case villoglandular endometrial cancer. Conclusion: Increased tendency of endometroid secretory adenocarcinoma of endometrium as 46 (65.71%) cases out of 70 cases.
    VL  - 3
    IS  - 3
    ER  - 

    Copy | Download

Author Information
  • Department of Pathology, Shaheed Mohtarma Benazir Bhutto Medical College, Karachi, Pakistan

  • Department of Physiology, Shaheed Mohtarma Benazir Bhutto Medical College, Karachi, Pakistan

  • Department Community Health Sciences, Ziauddin University, Karachi, Pakistan

  • Department of Physiology, University of Sindh, Jamshoro, Sindh, Pakistan

  • Sections