Plasma Protein Z Levels in Healthy and High-Risk Newborn Infants

Ahmed Anower Khattab; Fathia Mohamed El Nemr; Rania Salah El Zayat; Mohmmed Soliman Rizk; Shimaa Fetouh Elbakly

doi:doi:10.11648/j.bio.20140206.12

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Plasma Protein Z Levels in Healthy and High-Risk Newborn Infants

Ahmed Anower Khattab, Fathia Mohamed El Nemr, Rania Salah El Zayat, Mohmmed Soliman Rizk, Shimaa Fetouh Elbakly

Published in American Journal of Bioscience and Bioengineering (Volume 2, Issue 6)

Received: 24 November 2014 Accepted: 11 December 2014 Published: 21 January 2015

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Abstract

Objectives: To evaluate plasma protein Z (PZ) levels in healthy and high-risk newborn infants. Background: Protein Z (PZ) is a vitamin K-dependent plasma protein , As is the case with other coagulation proteins and inhibitors, protein Z is consumed during disseminated intravascular coagulation (DIC), Functionally protein Z has been shown to be a direct requirement for the binding of thrombin to endothelial phospholipids , Protein Z also serves as a cofactor for the inhibition of coagulation factor Xa by a plasma serein called protein Z-dependent protease inhibitor (ZPI), The inhibitory function is exerted by the Protein Z- dependent protease inhibitor (ZPI), which circulates in the human plasma in a complex with PZ , The physiological function of protein Z is still rather ill-defined and may play role in high risk newborn. Methods: This study was conducted on 85 newborns divided in 4 groups ,(group I newborns affected by respiratory distress syndrome (RDS) , group II newborns from mothers with pre-eclampsia, group III newborns small for gestational age (SGA) and group IV healthy term and preterm newborns normal for gestational age. Newborns with sepsis, congenital malformation or hemorrhagic disorders were excluded, Plasma PZ levels was measured. Results: In the neonates of the study groups, protein z level was significant lower in patient group than control group, in group I ( 0.79 ±0.32), group II (0.70± 0.30), group III (0.78 ±0.32) and group IV (1.44 ±0.43) (p value<0.001). Conclusion: PZ deficiency occurs in newborns affected by severe RDS, in newborns from preeclampsic mothers and in SGA newborns, probably owing to activated coagulation in the first two conditions and to reduced PZ synthesis in the last one.

Published in	American Journal of Bioscience and Bioengineering (Volume 2, Issue 6)
DOI	10.11648/j.bio.20140206.12
Page(s)	78-82
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2015. Published by Science Publishing Group

Keywords

Hemostasis, Healthy Newborns, Newborns from Mothers Affected by Pre-Eclampsia and SGA Newborns, High-Risk Newborns, Protein Z, Respiratory Distress Syndrome

References

[1]	Broze GJ, Jr(2004). Protein Z-dependent regulation of coagulation. J Thromb Haemost.;86:8-13.
[2]	Carl H. Backes, Kara Markham, Pamela Moorehead, Leandro Cordero, Craig A. Nankervis, and Peter J (2011). Giannone Maternal Preeclampsia and Neonatal Outcomes, J Pregnancy; 214365.
[3]	Corral, J., R. Gonzalez, D. Espinosa and V. Vicente, 2007. Protein Z/Z-dependent protease inhibitor (PZ/ZPI) anticoagulant system and thrombosis. Br. J. Haematol., 137: 99-108.\|
[4]	Grignani G, Maiolo A. Cytokines and hemostasis. Haematologica 2002; 85: 967–72.
[5]	Idell, S., (2009). Anticoagulats for Acute respiratory distresss syndrome. Am. J. Respir. Crit. Care Med., 164: 517-520.
[6]	Kemkes-Matthes, B. and Matthes, K.J (2000)., Biomed Progress, 13, 51.
[7]	Ioannis , Taxiarchis , Spiridon G, Lefkothea D, Eleni D, Georgios V et al (2009). Protein Z Plasma Levels are Not Elevated in Patients with Non-Arteritic Anterior Ischemic Optic Neuropathy. The Open Ophthalmology Journal, 2009, 3, 15-19 15
[8]	Martin JA, Hamilton BE, Sutton PD, et al (2007). National Vital Statistics Reports.;56(6):1–103.
[9]	Offer E, , Debra H, Roberto Ro, Jimmy E , Luis G, Jyh K N, et al (2008). Preeclampsia Is Associated with Low Concentrations of Protein Z, J Matern Fetal Neonatal Med. 20(9): 661–667.
[10]	Rezaie, A 2005., J Biol Chem. September 23; 280(38).
[11]	Röhl, K Jäger D and Barth J (2006). Protein-Z-deficiency as a rare case of unexpected perioperative bleeding in a patient with spinal cord injury published online 44, 636–639.
[12]	Schettini, F., N. Laforgia, M. Altomare, A. Matuone and G.C. Del-Vecchio, 2004. Plasma protein Z levels in healthy and high-risk newborn infants. Acta Paediatr., 93: 654-657.
[13]	Tabatabai A, Fiehler R, Broze GJ, Jr(2010). Protein Zcirculates in plasma in a complex with protein Z dependent protease inhibitor. J Thromb Haemost.85:655-660.
[14]	Ware, L.B., M.A. Matthay, P.E. Parsons, B.T. Thompson, J.L. Januzzi and M.D. Eisner, (2007). Pathogenetic and prognostic significance of altered coagulation and fibrinolysis in acute lung injury/acute respiratory distress syndrome. Crit. Care Med., 35: 1821-1828. 15.
[15]	Yurdakok, M., A. Korkmaz, S. Kirazli, C. Aygun and S. Yigit, 2006. Global fibrinolytic capacity in Early Respiratory distress syndrome: A pilot study. Am. J. Hematol., 69: 255-257.

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APA Style

Ahmed Anower Khattab, Fathia Mohamed El Nemr, Rania Salah El Zayat, Mohmmed Soliman Rizk, Shimaa Fetouh Elbakly. (2015). Plasma Protein Z Levels in Healthy and High-Risk Newborn Infants. American Journal of Bioscience and Bioengineering, 2(6), 78-82. https://doi.org/10.11648/j.bio.20140206.12

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ACS Style

Ahmed Anower Khattab; Fathia Mohamed El Nemr; Rania Salah El Zayat; Mohmmed Soliman Rizk; Shimaa Fetouh Elbakly. Plasma Protein Z Levels in Healthy and High-Risk Newborn Infants. Am. J. BioSci. Bioeng. 2015, 2(6), 78-82. doi: 10.11648/j.bio.20140206.12

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AMA Style

Ahmed Anower Khattab, Fathia Mohamed El Nemr, Rania Salah El Zayat, Mohmmed Soliman Rizk, Shimaa Fetouh Elbakly. Plasma Protein Z Levels in Healthy and High-Risk Newborn Infants. Am J BioSci Bioeng. 2015;2(6):78-82. doi: 10.11648/j.bio.20140206.12

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@article{10.11648/j.bio.20140206.12,
  author = {Ahmed Anower Khattab and Fathia Mohamed El Nemr and Rania Salah El Zayat and Mohmmed Soliman Rizk and Shimaa Fetouh Elbakly},
  title = {Plasma Protein Z Levels in Healthy and High-Risk Newborn Infants},
  journal = {American Journal of Bioscience and Bioengineering},
  volume = {2},
  number = {6},
  pages = {78-82},
  doi = {10.11648/j.bio.20140206.12},
  url = {https://doi.org/10.11648/j.bio.20140206.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.bio.20140206.12},
  abstract = {Objectives: To evaluate plasma protein Z (PZ) levels in healthy and high-risk newborn infants. Background: Protein Z (PZ) is a vitamin K-dependent plasma protein , As is the case with other coagulation proteins and inhibitors, protein Z is consumed during disseminated intravascular coagulation (DIC), Functionally protein Z has been shown to be a direct requirement for the binding of thrombin to endothelial phospholipids , Protein Z also serves as a cofactor for the inhibition of coagulation factor Xa by a plasma serein called protein Z-dependent protease inhibitor (ZPI), The inhibitory function is exerted by the Protein Z- dependent protease inhibitor (ZPI), which circulates in the human plasma in a complex with PZ , The physiological function of protein Z is still rather ill-defined and may play role in high risk newborn. Methods: This study was conducted on 85 newborns divided in 4 groups ,(group I newborns affected by respiratory distress syndrome (RDS) , group II newborns from mothers with pre-eclampsia, group III newborns small for gestational age (SGA) and group IV healthy term and preterm newborns normal for gestational age. Newborns with sepsis, congenital malformation or hemorrhagic disorders were excluded, Plasma PZ levels was measured. Results: In the neonates of the study groups, protein z level was significant lower in patient group than control group, in group I ( 0.79 ±0.32), group II (0.70± 0.30), group III (0.78 ±0.32) and group IV (1.44 ±0.43) (p value<0.001). Conclusion: PZ deficiency occurs in newborns affected by severe RDS, in newborns from preeclampsic mothers and in SGA newborns, probably owing to activated coagulation in the first two conditions and to reduced PZ synthesis in the last one.},
 year = {2015}
}

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TY  - JOUR
T1  - Plasma Protein Z Levels in Healthy and High-Risk Newborn Infants
AU  - Ahmed Anower Khattab
AU  - Fathia Mohamed El Nemr
AU  - Rania Salah El Zayat
AU  - Mohmmed Soliman Rizk
AU  - Shimaa Fetouh Elbakly
Y1  - 2015/01/21
PY  - 2015
N1  - https://doi.org/10.11648/j.bio.20140206.12
DO  - 10.11648/j.bio.20140206.12
T2  - American Journal of Bioscience and Bioengineering
JF  - American Journal of Bioscience and Bioengineering
JO  - American Journal of Bioscience and Bioengineering
SP  - 78
EP  - 82
PB  - Science Publishing Group
SN  - 2328-5893
UR  - https://doi.org/10.11648/j.bio.20140206.12
AB  - Objectives: To evaluate plasma protein Z (PZ) levels in healthy and high-risk newborn infants. Background: Protein Z (PZ) is a vitamin K-dependent plasma protein , As is the case with other coagulation proteins and inhibitors, protein Z is consumed during disseminated intravascular coagulation (DIC), Functionally protein Z has been shown to be a direct requirement for the binding of thrombin to endothelial phospholipids , Protein Z also serves as a cofactor for the inhibition of coagulation factor Xa by a plasma serein called protein Z-dependent protease inhibitor (ZPI), The inhibitory function is exerted by the Protein Z- dependent protease inhibitor (ZPI), which circulates in the human plasma in a complex with PZ , The physiological function of protein Z is still rather ill-defined and may play role in high risk newborn. Methods: This study was conducted on 85 newborns divided in 4 groups ,(group I newborns affected by respiratory distress syndrome (RDS) , group II newborns from mothers with pre-eclampsia, group III newborns small for gestational age (SGA) and group IV healthy term and preterm newborns normal for gestational age. Newborns with sepsis, congenital malformation or hemorrhagic disorders were excluded, Plasma PZ levels was measured. Results: In the neonates of the study groups, protein z level was significant lower in patient group than control group, in group I ( 0.79 ±0.32), group II (0.70± 0.30), group III (0.78 ±0.32) and group IV (1.44 ±0.43) (p value<0.001). Conclusion: PZ deficiency occurs in newborns affected by severe RDS, in newborns from preeclampsic mothers and in SGA newborns, probably owing to activated coagulation in the first two conditions and to reduced PZ synthesis in the last one.
VL  - 2
IS  - 6
ER  -

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Author Information

Ahmed Anower Khattab

Pediatrics department, Faculty of Medicine, Menoufia University, Shebin El-Kom, Menoufia, Egypt
Fathia Mohamed El Nemr

Pediatrics department, Faculty of Medicine, Menoufia University, Shebin El-Kom, Menoufia, Egypt
Rania Salah El Zayat

Pediatrics department, Faculty of Medicine, Menoufia University, Shebin El-Kom, Menoufia, Egypt
Mohmmed Soliman Rizk

Biochimistry Department, Faculty of Medicine, Menoufia University, Shebin El-Kom, Menoufia, Egypt
Shimaa Fetouh Elbakly

Pediatrics resident, Tala Central Hospital, Tala, Menoufiya, Egypt

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APA Style

Ahmed Anower Khattab, Fathia Mohamed El Nemr, Rania Salah El Zayat, Mohmmed Soliman Rizk, Shimaa Fetouh Elbakly. (2015). Plasma Protein Z Levels in Healthy and High-Risk Newborn Infants. American Journal of Bioscience and Bioengineering, 2(6), 78-82. https://doi.org/10.11648/j.bio.20140206.12

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ACS Style

Ahmed Anower Khattab; Fathia Mohamed El Nemr; Rania Salah El Zayat; Mohmmed Soliman Rizk; Shimaa Fetouh Elbakly. Plasma Protein Z Levels in Healthy and High-Risk Newborn Infants. Am. J. BioSci. Bioeng. 2015, 2(6), 78-82. doi: 10.11648/j.bio.20140206.12

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AMA Style

Ahmed Anower Khattab, Fathia Mohamed El Nemr, Rania Salah El Zayat, Mohmmed Soliman Rizk, Shimaa Fetouh Elbakly. Plasma Protein Z Levels in Healthy and High-Risk Newborn Infants. Am J BioSci Bioeng. 2015;2(6):78-82. doi: 10.11648/j.bio.20140206.12

Copy | Download

@article{10.11648/j.bio.20140206.12,
  author = {Ahmed Anower Khattab and Fathia Mohamed El Nemr and Rania Salah El Zayat and Mohmmed Soliman Rizk and Shimaa Fetouh Elbakly},
  title = {Plasma Protein Z Levels in Healthy and High-Risk Newborn Infants},
  journal = {American Journal of Bioscience and Bioengineering},
  volume = {2},
  number = {6},
  pages = {78-82},
  doi = {10.11648/j.bio.20140206.12},
  url = {https://doi.org/10.11648/j.bio.20140206.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.bio.20140206.12},
  abstract = {Objectives: To evaluate plasma protein Z (PZ) levels in healthy and high-risk newborn infants. Background: Protein Z (PZ) is a vitamin K-dependent plasma protein , As is the case with other coagulation proteins and inhibitors, protein Z is consumed during disseminated intravascular coagulation (DIC), Functionally protein Z has been shown to be a direct requirement for the binding of thrombin to endothelial phospholipids , Protein Z also serves as a cofactor for the inhibition of coagulation factor Xa by a plasma serein called protein Z-dependent protease inhibitor (ZPI), The inhibitory function is exerted by the Protein Z- dependent protease inhibitor (ZPI), which circulates in the human plasma in a complex with PZ , The physiological function of protein Z is still rather ill-defined and may play role in high risk newborn. Methods: This study was conducted on 85 newborns divided in 4 groups ,(group I newborns affected by respiratory distress syndrome (RDS) , group II newborns from mothers with pre-eclampsia, group III newborns small for gestational age (SGA) and group IV healthy term and preterm newborns normal for gestational age. Newborns with sepsis, congenital malformation or hemorrhagic disorders were excluded, Plasma PZ levels was measured. Results: In the neonates of the study groups, protein z level was significant lower in patient group than control group, in group I ( 0.79 ±0.32), group II (0.70± 0.30), group III (0.78 ±0.32) and group IV (1.44 ±0.43) (p value<0.001). Conclusion: PZ deficiency occurs in newborns affected by severe RDS, in newborns from preeclampsic mothers and in SGA newborns, probably owing to activated coagulation in the first two conditions and to reduced PZ synthesis in the last one.},
 year = {2015}
}

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TY  - JOUR
T1  - Plasma Protein Z Levels in Healthy and High-Risk Newborn Infants
AU  - Ahmed Anower Khattab
AU  - Fathia Mohamed El Nemr
AU  - Rania Salah El Zayat
AU  - Mohmmed Soliman Rizk
AU  - Shimaa Fetouh Elbakly
Y1  - 2015/01/21
PY  - 2015
N1  - https://doi.org/10.11648/j.bio.20140206.12
DO  - 10.11648/j.bio.20140206.12
T2  - American Journal of Bioscience and Bioengineering
JF  - American Journal of Bioscience and Bioengineering
JO  - American Journal of Bioscience and Bioengineering
SP  - 78
EP  - 82
PB  - Science Publishing Group
SN  - 2328-5893
UR  - https://doi.org/10.11648/j.bio.20140206.12
AB  - Objectives: To evaluate plasma protein Z (PZ) levels in healthy and high-risk newborn infants. Background: Protein Z (PZ) is a vitamin K-dependent plasma protein , As is the case with other coagulation proteins and inhibitors, protein Z is consumed during disseminated intravascular coagulation (DIC), Functionally protein Z has been shown to be a direct requirement for the binding of thrombin to endothelial phospholipids , Protein Z also serves as a cofactor for the inhibition of coagulation factor Xa by a plasma serein called protein Z-dependent protease inhibitor (ZPI), The inhibitory function is exerted by the Protein Z- dependent protease inhibitor (ZPI), which circulates in the human plasma in a complex with PZ , The physiological function of protein Z is still rather ill-defined and may play role in high risk newborn. Methods: This study was conducted on 85 newborns divided in 4 groups ,(group I newborns affected by respiratory distress syndrome (RDS) , group II newborns from mothers with pre-eclampsia, group III newborns small for gestational age (SGA) and group IV healthy term and preterm newborns normal for gestational age. Newborns with sepsis, congenital malformation or hemorrhagic disorders were excluded, Plasma PZ levels was measured. Results: In the neonates of the study groups, protein z level was significant lower in patient group than control group, in group I ( 0.79 ±0.32), group II (0.70± 0.30), group III (0.78 ±0.32) and group IV (1.44 ±0.43) (p value<0.001). Conclusion: PZ deficiency occurs in newborns affected by severe RDS, in newborns from preeclampsic mothers and in SGA newborns, probably owing to activated coagulation in the first two conditions and to reduced PZ synthesis in the last one.
VL  - 2
IS  - 6
ER  -

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