Involvement of Pro-Apoptotic and Pro-Autophagic Proteins in Granulosa Cell Death

Escobar M. L.; Echeverría O .M.; Casasa A .S.; García G.; Aguilar S. J.; Vázquez-Nin G.H.

doi:doi:10.11648/j.cb.20130101.12

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Involvement of Pro-Apoptotic and Pro-Autophagic Proteins in Granulosa Cell Death

Escobar M. L., Echeverría O .M., Casasa A .S., García G., Aguilar S. J., Vázquez-Nin G.H.

Published in Cell Biology (Volume 1, Issue 1)

Received: 3 May 2013 Published: 20 May 2013

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Abstract

Follicular atresia is a process present in all mammals studied. It involves the oocyte and granulosa cells. The apoptotic cell death has been implicated in follicular atresia. Now it is known that the autophagy is a programmed cell death. In this work, atretic follicles of Wistar rats’ ovaries were analyzed, to evaluate the routes of granulosa cell death during the follicular atresia. The apoptosis and autophagy presence was studied by means of ultrastructural and immunohis-tochemical techniques, and by molecular procedures. During atresia, follicular cells undergo the standard processes of cell death, apoptosis and autophagy, as well as a process in which features of both occur in the same cell. Other processes of cell death affect only granulosa cells and involve such features as contraction of cell volume, an increase of the lumen of the nuclear envelope and the endoplasmic reticulum, and loss of contacts with the oocyte, which is also altered.

Published in	Cell Biology (Volume 1, Issue 1)
DOI	10.11648/j.cb.20130101.12
Page(s)	9-17
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2013. Published by Science Publishing Group

Keywords

Atresia, Apoptosis, Autophagy, Granulosa Cell

References

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APA Style

Escobar M. L., Echeverría O .M., Casasa A .S., García G., Aguilar S. J., et al. (2013). Involvement of Pro-Apoptotic and Pro-Autophagic Proteins in Granulosa Cell Death. Cell Biology, 1(1), 9-17. https://doi.org/10.11648/j.cb.20130101.12

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ACS Style

Escobar M. L.; Echeverría O .M.; Casasa A .S.; García G.; Aguilar S. J., et al. Involvement of Pro-Apoptotic and Pro-Autophagic Proteins in Granulosa Cell Death. Cell Biol. 2013, 1(1), 9-17. doi: 10.11648/j.cb.20130101.12

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AMA Style

Escobar M. L., Echeverría O .M., Casasa A .S., García G., Aguilar S. J., et al. Involvement of Pro-Apoptotic and Pro-Autophagic Proteins in Granulosa Cell Death. Cell Biol. 2013;1(1):9-17. doi: 10.11648/j.cb.20130101.12

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@article{10.11648/j.cb.20130101.12,
  author = {Escobar M. L. and Echeverría O .M. and Casasa A .S. and García G. and Aguilar S. J. and Vázquez-Nin G.H.},
  title = {Involvement of Pro-Apoptotic and Pro-Autophagic Proteins in Granulosa Cell Death},
  journal = {Cell Biology},
  volume = {1},
  number = {1},
  pages = {9-17},
  doi = {10.11648/j.cb.20130101.12},
  url = {https://doi.org/10.11648/j.cb.20130101.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.cb.20130101.12},
  abstract = {Follicular atresia is a process present in all mammals studied. It involves the oocyte and granulosa cells. The apoptotic cell death has been implicated in follicular atresia. Now it is known that the autophagy is a programmed cell death. In this work, atretic follicles of Wistar rats’ ovaries were analyzed, to evaluate the routes of granulosa cell death during the follicular atresia. The apoptosis and autophagy presence was studied by means of ultrastructural and immunohis-tochemical techniques, and by molecular procedures. During atresia, follicular cells undergo the standard processes of cell death, apoptosis and autophagy, as well as a process in which features of both occur in the same cell. Other processes of cell death affect only granulosa cells and involve such features as contraction of cell volume, an increase of the lumen of the nuclear envelope and the endoplasmic reticulum, and loss of contacts with the oocyte, which is also altered.},
 year = {2013}
}

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TY  - JOUR
T1  - Involvement of Pro-Apoptotic and Pro-Autophagic Proteins in Granulosa Cell Death
AU  - Escobar M. L.
AU  - Echeverría O .M.
AU  - Casasa A .S.
AU  - García G.
AU  - Aguilar S. J.
AU  - Vázquez-Nin G.H.
Y1  - 2013/05/20
PY  - 2013
N1  - https://doi.org/10.11648/j.cb.20130101.12
DO  - 10.11648/j.cb.20130101.12
T2  - Cell Biology
JF  - Cell Biology
JO  - Cell Biology
SP  - 9
EP  - 17
PB  - Science Publishing Group
SN  - 2330-0183
UR  - https://doi.org/10.11648/j.cb.20130101.12
AB  - Follicular atresia is a process present in all mammals studied. It involves the oocyte and granulosa cells. The apoptotic cell death has been implicated in follicular atresia. Now it is known that the autophagy is a programmed cell death. In this work, atretic follicles of Wistar rats’ ovaries were analyzed, to evaluate the routes of granulosa cell death during the follicular atresia. The apoptosis and autophagy presence was studied by means of ultrastructural and immunohis-tochemical techniques, and by molecular procedures. During atresia, follicular cells undergo the standard processes of cell death, apoptosis and autophagy, as well as a process in which features of both occur in the same cell. Other processes of cell death affect only granulosa cells and involve such features as contraction of cell volume, an increase of the lumen of the nuclear envelope and the endoplasmic reticulum, and loss of contacts with the oocyte, which is also altered.
VL  - 1
IS  - 1
ER  -

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Author Information

Escobar M. L.

Laboratorio de Microscopía Electrónica. Departamento de Biología Celular. Facultad de Ciencias. Universidad Nacional Autónoma de México (UNAM)
Echeverría O .M.

Laboratorio de Microscopía Electrónica. Departamento de Biología Celular. Facultad de Ciencias. Universidad Nacional Autónoma de México (UNAM)
Casasa A .S.

Laboratorio de Microscopía Electrónica. Departamento de Biología Celular. Facultad de Ciencias. Universidad Nacional Autónoma de México (UNAM)
García G.

Laboratorio de Microscopía Electrónica. Departamento de Biología Celular. Facultad de Ciencias. Universidad Nacional Autónoma de México (UNAM)
Aguilar S. J.

Laboratorio de Microscopía Electrónica. Departamento de Biología Celular. Facultad de Ciencias. Universidad Nacional Autónoma de México (UNAM)
Vázquez-Nin G.H.

Laboratorio de Microscopía Electrónica. Departamento de Biología Celular. Facultad de Ciencias. Universidad Nacional Autónoma de México (UNAM)

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APA Style

Escobar M. L., Echeverría O .M., Casasa A .S., García G., Aguilar S. J., et al. (2013). Involvement of Pro-Apoptotic and Pro-Autophagic Proteins in Granulosa Cell Death. Cell Biology, 1(1), 9-17. https://doi.org/10.11648/j.cb.20130101.12

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ACS Style

Escobar M. L.; Echeverría O .M.; Casasa A .S.; García G.; Aguilar S. J., et al. Involvement of Pro-Apoptotic and Pro-Autophagic Proteins in Granulosa Cell Death. Cell Biol. 2013, 1(1), 9-17. doi: 10.11648/j.cb.20130101.12

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AMA Style

Escobar M. L., Echeverría O .M., Casasa A .S., García G., Aguilar S. J., et al. Involvement of Pro-Apoptotic and Pro-Autophagic Proteins in Granulosa Cell Death. Cell Biol. 2013;1(1):9-17. doi: 10.11648/j.cb.20130101.12

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@article{10.11648/j.cb.20130101.12,
  author = {Escobar M. L. and Echeverría O .M. and Casasa A .S. and García G. and Aguilar S. J. and Vázquez-Nin G.H.},
  title = {Involvement of Pro-Apoptotic and Pro-Autophagic Proteins in Granulosa Cell Death},
  journal = {Cell Biology},
  volume = {1},
  number = {1},
  pages = {9-17},
  doi = {10.11648/j.cb.20130101.12},
  url = {https://doi.org/10.11648/j.cb.20130101.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.cb.20130101.12},
  abstract = {Follicular atresia is a process present in all mammals studied. It involves the oocyte and granulosa cells. The apoptotic cell death has been implicated in follicular atresia. Now it is known that the autophagy is a programmed cell death. In this work, atretic follicles of Wistar rats’ ovaries were analyzed, to evaluate the routes of granulosa cell death during the follicular atresia. The apoptosis and autophagy presence was studied by means of ultrastructural and immunohis-tochemical techniques, and by molecular procedures. During atresia, follicular cells undergo the standard processes of cell death, apoptosis and autophagy, as well as a process in which features of both occur in the same cell. Other processes of cell death affect only granulosa cells and involve such features as contraction of cell volume, an increase of the lumen of the nuclear envelope and the endoplasmic reticulum, and loss of contacts with the oocyte, which is also altered.},
 year = {2013}
}

Copy | Download

TY  - JOUR
T1  - Involvement of Pro-Apoptotic and Pro-Autophagic Proteins in Granulosa Cell Death
AU  - Escobar M. L.
AU  - Echeverría O .M.
AU  - Casasa A .S.
AU  - García G.
AU  - Aguilar S. J.
AU  - Vázquez-Nin G.H.
Y1  - 2013/05/20
PY  - 2013
N1  - https://doi.org/10.11648/j.cb.20130101.12
DO  - 10.11648/j.cb.20130101.12
T2  - Cell Biology
JF  - Cell Biology
JO  - Cell Biology
SP  - 9
EP  - 17
PB  - Science Publishing Group
SN  - 2330-0183
UR  - https://doi.org/10.11648/j.cb.20130101.12
AB  - Follicular atresia is a process present in all mammals studied. It involves the oocyte and granulosa cells. The apoptotic cell death has been implicated in follicular atresia. Now it is known that the autophagy is a programmed cell death. In this work, atretic follicles of Wistar rats’ ovaries were analyzed, to evaluate the routes of granulosa cell death during the follicular atresia. The apoptosis and autophagy presence was studied by means of ultrastructural and immunohis-tochemical techniques, and by molecular procedures. During atresia, follicular cells undergo the standard processes of cell death, apoptosis and autophagy, as well as a process in which features of both occur in the same cell. Other processes of cell death affect only granulosa cells and involve such features as contraction of cell volume, an increase of the lumen of the nuclear envelope and the endoplasmic reticulum, and loss of contacts with the oocyte, which is also altered.
VL  - 1
IS  - 1
ER  -

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