Sphingolipids such as ceramide, sphingosine and sphingosine 1-phosphate [S1P] are key regulators of various cellular functions. Sphingolipids mediates of cell-stress responses and regulate mitochondrial function. Ceramide and its metabolites play an important role in the development and progression of mitochondria related disorders. Ceramide functions as an important second messenger in apoptosis signaling and is generated by de novo synthesis, sphingomyelin hydrolysis, or recycling of sphingolipids. S1P, a potent signaling sphingolipid exerts myriads of pathophysiological function, including lymphocyte trafficking, angiogenesis, vascular development and inflammation. This review is focused on the role of signaling sphingolipids, such as S1P, sphingosine, and ceramide-1 phosphate on mitochondrial function, particularly mitochondrial respiratory function, apoptosis and calcium homeostasis. Further, we discuss the role of sphingolipids in mitochondrial diseases and targeting them for drug development. This review article is a part of special issue on Mitochondria: Implications in human health and disease.
| Published in |
Cell Biology (Volume 3, Issue 2-1)
This article belongs to the Special Issue Mitochondria: Implications in Human Health and Diseases |
| DOI | 10.11648/j.cb.s.2015030201.11 |
| Page(s) | 1-7 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2015. Published by Science Publishing Group |
Sphingolipid, Ceramide, Sphingosine-1-Phosphate [S1P], Mitochondria, Apoptosis
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APA Style
Rajeev Nema, Ashok Kumar. (2015). Regulation of Mitochondrial Function by Bioactive Sphingolipids. Cell Biology, 3(2-1), 1-7. https://doi.org/10.11648/j.cb.s.2015030201.11
ACS Style
Rajeev Nema; Ashok Kumar. Regulation of Mitochondrial Function by Bioactive Sphingolipids. Cell Biol. 2015, 3(2-1), 1-7. doi: 10.11648/j.cb.s.2015030201.11
AMA Style
Rajeev Nema, Ashok Kumar. Regulation of Mitochondrial Function by Bioactive Sphingolipids. Cell Biol. 2015;3(2-1):1-7. doi: 10.11648/j.cb.s.2015030201.11
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Download@article{10.11648/j.cb.s.2015030201.11,
author = {Rajeev Nema and Ashok Kumar},
title = {Regulation of Mitochondrial Function by Bioactive Sphingolipids},
journal = {Cell Biology},
volume = {3},
number = {2-1},
pages = {1-7},
doi = {10.11648/j.cb.s.2015030201.11},
url = {https://doi.org/10.11648/j.cb.s.2015030201.11},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.cb.s.2015030201.11},
abstract = {Sphingolipids such as ceramide, sphingosine and sphingosine 1-phosphate [S1P] are key regulators of various cellular functions. Sphingolipids mediates of cell-stress responses and regulate mitochondrial function. Ceramide and its metabolites play an important role in the development and progression of mitochondria related disorders. Ceramide functions as an important second messenger in apoptosis signaling and is generated by de novo synthesis, sphingomyelin hydrolysis, or recycling of sphingolipids. S1P, a potent signaling sphingolipid exerts myriads of pathophysiological function, including lymphocyte trafficking, angiogenesis, vascular development and inflammation. This review is focused on the role of signaling sphingolipids, such as S1P, sphingosine, and ceramide-1 phosphate on mitochondrial function, particularly mitochondrial respiratory function, apoptosis and calcium homeostasis. Further, we discuss the role of sphingolipids in mitochondrial diseases and targeting them for drug development. This review article is a part of special issue on Mitochondria: Implications in human health and disease.},
year = {2015}
}
TY - JOUR T1 - Regulation of Mitochondrial Function by Bioactive Sphingolipids AU - Rajeev Nema AU - Ashok Kumar Y1 - 2015/02/10 PY - 2015 N1 - https://doi.org/10.11648/j.cb.s.2015030201.11 DO - 10.11648/j.cb.s.2015030201.11 T2 - Cell Biology JF - Cell Biology JO - Cell Biology SP - 1 EP - 7 PB - Science Publishing Group SN - 2330-0183 UR - https://doi.org/10.11648/j.cb.s.2015030201.11 AB - Sphingolipids such as ceramide, sphingosine and sphingosine 1-phosphate [S1P] are key regulators of various cellular functions. Sphingolipids mediates of cell-stress responses and regulate mitochondrial function. Ceramide and its metabolites play an important role in the development and progression of mitochondria related disorders. Ceramide functions as an important second messenger in apoptosis signaling and is generated by de novo synthesis, sphingomyelin hydrolysis, or recycling of sphingolipids. S1P, a potent signaling sphingolipid exerts myriads of pathophysiological function, including lymphocyte trafficking, angiogenesis, vascular development and inflammation. This review is focused on the role of signaling sphingolipids, such as S1P, sphingosine, and ceramide-1 phosphate on mitochondrial function, particularly mitochondrial respiratory function, apoptosis and calcium homeostasis. Further, we discuss the role of sphingolipids in mitochondrial diseases and targeting them for drug development. This review article is a part of special issue on Mitochondria: Implications in human health and disease. VL - 3 IS - 2-1 ER -
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