Background: Early diagnosis of rheumatoid arthritis and timely detection of progression are global challenges. However, lack of sensitivity and imprecision of the currently available biomarkers have impaired the ability to implement potentially effective therapies in a timely manner. The present study aimed to evaluate the clinical utility of serum calprotectin in diagnosis as well as assessment of rheumatoid arthritis activity. Methods: serum calprotectin levels were measured in 60 Egyptian patients with rheumatoid arthritis (35 patients with active rheumatoid arthritis vs. 25 patients with quiescent disease) and 20 healthy subjects who served as a control group. Results: Serum calprotectin showed a highly significant elevation in patients with rheumatoid arthritis. Moreover, its level showed a highly significant increase during disease activity. Significant positive correlations were found between serum calprotectin and other markers of disease activity (ESR, CRP, WBCs, and platelets). Serum calprotectin at a cut- off level of 450 ng /mL, had 75% sensitivity &90% specificity for diagnosis of rheumatoid arthritis. Optimum cut-off level of calprotectin for prediction of disease activity was 950 ng /mL with 80% sensitivity, 76% specificity. Conclusion: serum calprotectin is a promising marker for diagnosis and monitoring of disease activity in patients with rheumatoid arthritis.
| Published in | International Journal of Immunology (Volume 2, Issue 1) |
| DOI | 10.11648/j.iji.20140201.12 |
| Page(s) | 6-10 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2014. Published by Science Publishing Group |
Calprotectin, Rheumatoid, Arthritis, CRP
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APA Style
Nanees Adel, Marcel William, Reham Al Swaff, Sherin Hassan. (2014). Serum Calprotectin Level for Diagnosis and detection of Disease Activity in Rheumatoid Arthritis. International Journal of Immunology, 2(1), 6-10. https://doi.org/10.11648/j.iji.20140201.12
ACS Style
Nanees Adel; Marcel William; Reham Al Swaff; Sherin Hassan. Serum Calprotectin Level for Diagnosis and detection of Disease Activity in Rheumatoid Arthritis. Int. J. Immunol. 2014, 2(1), 6-10. doi: 10.11648/j.iji.20140201.12
AMA Style
Nanees Adel, Marcel William, Reham Al Swaff, Sherin Hassan. Serum Calprotectin Level for Diagnosis and detection of Disease Activity in Rheumatoid Arthritis. Int J Immunol. 2014;2(1):6-10. doi: 10.11648/j.iji.20140201.12
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Download@article{10.11648/j.iji.20140201.12,
author = {Nanees Adel and Marcel William and Reham Al Swaff and Sherin Hassan},
title = {Serum Calprotectin Level for Diagnosis and detection of Disease Activity in Rheumatoid Arthritis},
journal = {International Journal of Immunology},
volume = {2},
number = {1},
pages = {6-10},
doi = {10.11648/j.iji.20140201.12},
url = {https://doi.org/10.11648/j.iji.20140201.12},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.iji.20140201.12},
abstract = {Background: Early diagnosis of rheumatoid arthritis and timely detection of progression are global challenges. However, lack of sensitivity and imprecision of the currently available biomarkers have impaired the ability to implement potentially effective therapies in a timely manner. The present study aimed to evaluate the clinical utility of serum calprotectin in diagnosis as well as assessment of rheumatoid arthritis activity. Methods: serum calprotectin levels were measured in 60 Egyptian patients with rheumatoid arthritis (35 patients with active rheumatoid arthritis vs. 25 patients with quiescent disease) and 20 healthy subjects who served as a control group. Results: Serum calprotectin showed a highly significant elevation in patients with rheumatoid arthritis. Moreover, its level showed a highly significant increase during disease activity. Significant positive correlations were found between serum calprotectin and other markers of disease activity (ESR, CRP, WBCs, and platelets). Serum calprotectin at a cut- off level of 450 ng /mL, had 75% sensitivity &90% specificity for diagnosis of rheumatoid arthritis. Optimum cut-off level of calprotectin for prediction of disease activity was 950 ng /mL with 80% sensitivity, 76% specificity. Conclusion: serum calprotectin is a promising marker for diagnosis and monitoring of disease activity in patients with rheumatoid arthritis.},
year = {2014}
}
TY - JOUR T1 - Serum Calprotectin Level for Diagnosis and detection of Disease Activity in Rheumatoid Arthritis AU - Nanees Adel AU - Marcel William AU - Reham Al Swaff AU - Sherin Hassan Y1 - 2014/03/30 PY - 2014 N1 - https://doi.org/10.11648/j.iji.20140201.12 DO - 10.11648/j.iji.20140201.12 T2 - International Journal of Immunology JF - International Journal of Immunology JO - International Journal of Immunology SP - 6 EP - 10 PB - Science Publishing Group SN - 2329-1753 UR - https://doi.org/10.11648/j.iji.20140201.12 AB - Background: Early diagnosis of rheumatoid arthritis and timely detection of progression are global challenges. However, lack of sensitivity and imprecision of the currently available biomarkers have impaired the ability to implement potentially effective therapies in a timely manner. The present study aimed to evaluate the clinical utility of serum calprotectin in diagnosis as well as assessment of rheumatoid arthritis activity. Methods: serum calprotectin levels were measured in 60 Egyptian patients with rheumatoid arthritis (35 patients with active rheumatoid arthritis vs. 25 patients with quiescent disease) and 20 healthy subjects who served as a control group. Results: Serum calprotectin showed a highly significant elevation in patients with rheumatoid arthritis. Moreover, its level showed a highly significant increase during disease activity. Significant positive correlations were found between serum calprotectin and other markers of disease activity (ESR, CRP, WBCs, and platelets). Serum calprotectin at a cut- off level of 450 ng /mL, had 75% sensitivity &90% specificity for diagnosis of rheumatoid arthritis. Optimum cut-off level of calprotectin for prediction of disease activity was 950 ng /mL with 80% sensitivity, 76% specificity. Conclusion: serum calprotectin is a promising marker for diagnosis and monitoring of disease activity in patients with rheumatoid arthritis. VL - 2 IS - 1 ER -
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