In <i>Situ</i> Quantification and 3D Reconstruction of Thrombus in the Superficial Femoral Artery Disease Using Optical Coherence Tomography

Mehmet Cilingiroglu; Massoud Leesar; Taylor Hoyt; Austin Mcelroy; Thomas Milner; Konstantinos Marmagkiolis; Marc D. Feldman; Vasili Lendel

doi:doi:10.11648/j.ijmi.20150306.12

In Situ Quantification and 3D Reconstruction of Thrombus in the Superficial Femoral Artery Disease Using Optical Coherence Tomography

Mehmet Cilingiroglu, Massoud Leesar, Taylor Hoyt, Austin Mcelroy, Thomas Milner, Konstantinos Marmagkiolis, Marc D. Feldman, Vasili Lendel

Published in International Journal of Medical Imaging (Volume 3, Issue 6)

Received: 16 October 2015 Accepted: 24 October 2015 Published: 10 November 2015

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Abstract

Background: SFA disease accounts for approximately 40% of the symptomatic peripheral artery disease. Atherosclerosis and thrombosis both contribute in the progression of the peripheral arterial disease. Conventional angiography provides little information about the amount of the thrombus burden. Limited data exists on the use of OCT for the evaluation of PAD. Methods: We performed OCT in three patients with SFA disease who underwent peripheral angiogram from January 2011 – December 2014. Using custom-based imaging software we performed 3D reconstruction and quantification of intraluminal thrombus. Results: We identified thrombus formation in all three patients despite absence of evident thrombosis with invasive angiography. The length of the clot ranged from 12.6 - 47.7 mm and the volume from 11.19 - 43.26 mm3). Conclusion: Atherosclerosis and thrombosis both contribute in the progression of the peripheral arterial disease. OCT can accurately quantify the length and the volume of the clot burden. Larger studies are needed to assess their clinical importance in the prevention and management of PAD.

Published in	International Journal of Medical Imaging (Volume 3, Issue 6)
DOI	10.11648/j.ijmi.20150306.12
Page(s)	110-113
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2015. Published by Science Publishing Group

Keywords

OCT, 3D Reconstruction, PAD

References

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APA Style

Mehmet Cilingiroglu, Massoud Leesar, Taylor Hoyt, Austin Mcelroy, Thomas Milner, et al. (2015). In Situ Quantification and 3D Reconstruction of Thrombus in the Superficial Femoral Artery Disease Using Optical Coherence Tomography. International Journal of Medical Imaging, 3(6), 110-113. https://doi.org/10.11648/j.ijmi.20150306.12

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ACS Style

Mehmet Cilingiroglu; Massoud Leesar; Taylor Hoyt; Austin Mcelroy; Thomas Milner, et al. In Situ Quantification and 3D Reconstruction of Thrombus in the Superficial Femoral Artery Disease Using Optical Coherence Tomography. Int. J. Med. Imaging 2015, 3(6), 110-113. doi: 10.11648/j.ijmi.20150306.12

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AMA Style

Mehmet Cilingiroglu, Massoud Leesar, Taylor Hoyt, Austin Mcelroy, Thomas Milner, et al. In Situ Quantification and 3D Reconstruction of Thrombus in the Superficial Femoral Artery Disease Using Optical Coherence Tomography. Int J Med Imaging. 2015;3(6):110-113. doi: 10.11648/j.ijmi.20150306.12

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@article{10.11648/j.ijmi.20150306.12,
  author = {Mehmet Cilingiroglu and Massoud Leesar and Taylor Hoyt and Austin Mcelroy and Thomas Milner and Konstantinos Marmagkiolis and Marc D. Feldman and Vasili Lendel},
  title = {In Situ Quantification and 3D Reconstruction of Thrombus in the Superficial Femoral Artery Disease Using Optical Coherence Tomography},
  journal = {International Journal of Medical Imaging},
  volume = {3},
  number = {6},
  pages = {110-113},
  doi = {10.11648/j.ijmi.20150306.12},
  url = {https://doi.org/10.11648/j.ijmi.20150306.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijmi.20150306.12},
  abstract = {Background: SFA disease accounts for approximately 40% of the symptomatic peripheral artery disease. Atherosclerosis and thrombosis both contribute in the progression of the peripheral arterial disease. Conventional angiography provides little information about the amount of the thrombus burden. Limited data exists on the use of OCT for the evaluation of PAD. Methods: We performed OCT in three patients with SFA disease who underwent peripheral angiogram from January 2011 – December 2014. Using custom-based imaging software we performed 3D reconstruction and quantification of intraluminal thrombus. Results: We identified thrombus formation in all three patients despite absence of evident thrombosis with invasive angiography. The length of the clot ranged from 12.6 - 47.7 mm and the volume from 11.19 - 43.26 mm3). Conclusion: Atherosclerosis and thrombosis both contribute in the progression of the peripheral arterial disease. OCT can accurately quantify the length and the volume of the clot burden. Larger studies are needed to assess their clinical importance in the prevention and management of PAD.},
 year = {2015}
}

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TY - JOUR
T1 - In Situ Quantification and 3D Reconstruction of Thrombus in the Superficial Femoral Artery Disease Using Optical Coherence Tomography
AU - Mehmet Cilingiroglu
AU - Massoud Leesar
AU - Taylor Hoyt
AU - Austin Mcelroy
AU - Thomas Milner
AU - Konstantinos Marmagkiolis
AU - Marc D. Feldman
AU - Vasili Lendel
Y1 - 2015/11/10
PY - 2015
N1 - https://doi.org/10.11648/j.ijmi.20150306.12
DO - 10.11648/j.ijmi.20150306.12
T2 - International Journal of Medical Imaging
JF - International Journal of Medical Imaging
JO - International Journal of Medical Imaging
SP - 110
EP - 113
PB - Science Publishing Group
SN - 2330-832X
UR - https://doi.org/10.11648/j.ijmi.20150306.12
AB - Background: SFA disease accounts for approximately 40% of the symptomatic peripheral artery disease. Atherosclerosis and thrombosis both contribute in the progression of the peripheral arterial disease. Conventional angiography provides little information about the amount of the thrombus burden. Limited data exists on the use of OCT for the evaluation of PAD. Methods: We performed OCT in three patients with SFA disease who underwent peripheral angiogram from January 2011 – December 2014. Using custom-based imaging software we performed 3D reconstruction and quantification of intraluminal thrombus. Results: We identified thrombus formation in all three patients despite absence of evident thrombosis with invasive angiography. The length of the clot ranged from 12.6 - 47.7 mm and the volume from 11.19 - 43.26 mm3). Conclusion: Atherosclerosis and thrombosis both contribute in the progression of the peripheral arterial disease. OCT can accurately quantify the length and the volume of the clot burden. Larger studies are needed to assess their clinical importance in the prevention and management of PAD.
VL - 3
IS - 6
ER -

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Author Information

Mehmet Cilingiroglu

Arkansas Heart Hospital, Little Rock, AR, USA/Koc University, School of Medicine, Istanbul, Turkey
Massoud Leesar

University of Alabama at Birmingham, Department of Medicine, Section of Cardiology,Birmingham, AL,USA
Taylor Hoyt

University of Texas Health Sciences Center at San Antonio, Department of Medicine, Section of Cardiology, San Antonio, TX, San Antonio, TX, USA
Austin Mcelroy

University of Texas at Austin, Cockrell School of Biomedical Engineering, Austin, TX, USA
Thomas Milner

University of Texas at Austin, Cockrell School of Biomedical Engineering, Austin, TX, USA
Konstantinos Marmagkiolis

Citizens Memorial Hospital, Bolivar, MO, USA /University of Missouri, Columbia MO, USA
Marc D. Feldman

University of Texas Health Sciences Center at San Antonio, Department of Medicine, Section of Cardiology, San Antonio, TX, San Antonio, TX, USA
Vasili Lendel

Arkansas Heart Hospital, Little Rock, AR, USA/Koc University, School of Medicine, Istanbul, Turkey

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APA Style

Mehmet Cilingiroglu, Massoud Leesar, Taylor Hoyt, Austin Mcelroy, Thomas Milner, et al. (2015). In Situ Quantification and 3D Reconstruction of Thrombus in the Superficial Femoral Artery Disease Using Optical Coherence Tomography. International Journal of Medical Imaging, 3(6), 110-113. https://doi.org/10.11648/j.ijmi.20150306.12

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ACS Style

Mehmet Cilingiroglu; Massoud Leesar; Taylor Hoyt; Austin Mcelroy; Thomas Milner, et al. In Situ Quantification and 3D Reconstruction of Thrombus in the Superficial Femoral Artery Disease Using Optical Coherence Tomography. Int. J. Med. Imaging 2015, 3(6), 110-113. doi: 10.11648/j.ijmi.20150306.12

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AMA Style

Mehmet Cilingiroglu, Massoud Leesar, Taylor Hoyt, Austin Mcelroy, Thomas Milner, et al. In Situ Quantification and 3D Reconstruction of Thrombus in the Superficial Femoral Artery Disease Using Optical Coherence Tomography. Int J Med Imaging. 2015;3(6):110-113. doi: 10.11648/j.ijmi.20150306.12

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@article{10.11648/j.ijmi.20150306.12,
  author = {Mehmet Cilingiroglu and Massoud Leesar and Taylor Hoyt and Austin Mcelroy and Thomas Milner and Konstantinos Marmagkiolis and Marc D. Feldman and Vasili Lendel},
  title = {In Situ Quantification and 3D Reconstruction of Thrombus in the Superficial Femoral Artery Disease Using Optical Coherence Tomography},
  journal = {International Journal of Medical Imaging},
  volume = {3},
  number = {6},
  pages = {110-113},
  doi = {10.11648/j.ijmi.20150306.12},
  url = {https://doi.org/10.11648/j.ijmi.20150306.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijmi.20150306.12},
  abstract = {Background: SFA disease accounts for approximately 40% of the symptomatic peripheral artery disease. Atherosclerosis and thrombosis both contribute in the progression of the peripheral arterial disease. Conventional angiography provides little information about the amount of the thrombus burden. Limited data exists on the use of OCT for the evaluation of PAD. Methods: We performed OCT in three patients with SFA disease who underwent peripheral angiogram from January 2011 – December 2014. Using custom-based imaging software we performed 3D reconstruction and quantification of intraluminal thrombus. Results: We identified thrombus formation in all three patients despite absence of evident thrombosis with invasive angiography. The length of the clot ranged from 12.6 - 47.7 mm and the volume from 11.19 - 43.26 mm3). Conclusion: Atherosclerosis and thrombosis both contribute in the progression of the peripheral arterial disease. OCT can accurately quantify the length and the volume of the clot burden. Larger studies are needed to assess their clinical importance in the prevention and management of PAD.},
 year = {2015}
}

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