Nutritional State Impact on the Liver Detoxification Function in Patients Infected by HIV under Antiretroviral Drugs at the Bertoua Day Hospital of Cameroon

Marcellin Guiaro Ndoe; Armel Herve Nwabo Kamdje; Charles Fokunang Ntungwen; Michel Njan Nloga

doi:doi:10.11648/j.jdmp.20150102.13

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Nutritional State Impact on the Liver Detoxification Function in Patients Infected by HIV under Antiretroviral Drugs at the Bertoua Day Hospital of Cameroon

Marcellin Guiaro Ndoe, Armel Herve Nwabo Kamdje, Charles Fokunang Ntungwen, Michel Njan Nloga

Published in Journal of Diseases and Medicinal Plants (Volume 1, Issue 2)

Received: 5 June 2015 Accepted: 12 June 2015 Published: 23 June 2015

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Abstract

The present study aimed at evaluating the nutritional state impact on liver detoxification function in patients infected by the human immunodeficiency virus under antiretroviral drugs. We performed a retrospective and prospective transversal survey on the patients infected by the human immunodeficiency virus, under antiretroviral drugs at the Bertoua day hospital. The retrospective period of our survey went from October 24, 2014 to February 24, 2014 (4 months) and the prospective shutter of the survey went from February 24, 2014 to August 24, 2014 (6 months), a total period of 10 months. We also analysed the socio-demographics parameters (Age and Sex), Biological parameters (HIV type, CD4, Transaminases) and the therapeutics parameters (Therapeutic protocol, Evolution). The hepatic affection has been judged by the remarkable increase of the rate of transaminases (>3N) and by the appearance of hypersensitivity signs (Skin rashes, Fever…). During this survey, 38 hepatic-toxicity cases caused by the intake of ARV drugs were collected. We included 12 men (31.58%) and 26 women (68.42%) with a sex-ratio of 0.46 in favor of the women. The average age was 45.68±13.13 year with age ranging between 10 to 65 years. Age group of 50 years and above was most represented with a percentage of 42.10. The majority of the patients were infected by the HIV 1 (86.85%) against 10.52% for the HIV 2 and 2.63% for the HIV 1+2. The most prescribed therapy was the association of 2 INTI+1 INNTI (Tenofovir+Lamivudine+Nevirapine) and the AIDS stage represented 7.89%. Prior to the antiretroviral therapy, the 38 patients had normal transaminases that followed modifications of the initial therapeutic protocol after a remarkable increase during the antiretroviral therapy. We noted during this survey that the hepatotoxicity intervention of our patients under ARV drugs was correlated to their Body Mass Index (BMI) that allowed us to evaluate the nutritional state of our patients. The intervention of the hepatotoxicity during the antiretroviral therapy, among the HIV patients having a good nutritional state (normal BMI), was very weak in the absence of the predisposing factors.

Published in	Journal of Diseases and Medicinal Plants (Volume 1, Issue 2)
DOI	10.11648/j.jdmp.20150102.13
Page(s)	37-41
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2015. Published by Science Publishing Group

Keywords

Hepatic-toxicity, Transaminase, ARV, HIV, BMI

References

[1]	Aubry P., 2013. Le Sida tropical. In Epidémiologie des maladies parasitaires. Tome 3.Opportunistes.Editions Médicales Nationales. 78-89.
[2]	OMS. 2011. Revision des stratégies de dépistage du VIH pour la surveillance. REH. 81, 461-464.
[3]	Wit FW, Weverling GJ, Weel J, Jurriaans S, Lange JM. 2002. Incidence of and risk factors for severe hepatotoxicity associated with antiretroviral combination therapy. J Infect Dis. 186: 23-31.
[4]	Lemoine A, Ouazir K, Sgro C, Clinard F, Allard C, Guilleminet C. 2002. La fréquence des hépatites médicamenteuses est largement sous-estimée en France. Etude de population dans la Nièvre 1997-2000. Gastroenterol Clin Biol. 26 :399-8320.
[5]	Ponge T, Conttin S, Fruneau P, Ponge A., 1990. Hépatites médicamenteuses: situation dans la pathologie iatrogène. Résultat d’une enquête prospective. Med Chir Dig. 19: 105-109.
[6]	Seo JC, Jeon WJ, Park SS, Kim SH, Lee KM, Chae HB, Park SM, Youn SJ., 2006. Clinical experience of 48 acute toxic hepatitis patients. Korean j hepatol. 12(1): 74-81.
[7]	Tanon A, Binan Y, Minta D, Ehui E, Ouattara I, Mossou C, Kouakou, Eholié SP, Aoussi E, Bissagnéné E., 2002. Efficiency and safety of antiretroviral treatment among the elderly in Abidjan. J Infect Dis. 39-40.
[8]	Kremer H and Sonnenberg-Schwan U., 2003. Women Living with HIV Does Sex and Gender Matter? A Current Literature Review." Eur J Med Res. 8(1): 8-16.
[9]	Bersoff-Matcha SJ, Miller WC, Aberg JA, Van Der Horst C, Hamrick Jr, Powderly WG, Mundy LM., 2001. Sex differences in nevirapine rash. Clin Infect Dis. 32(1): 124-9.
[10]	Nunez M, Lana R, Mendoza JL, Martin-Carbonero L, Soriano V., 2001. Risk factors for severe hepatic injury after introduction of highly active antiretroviral therapy. J Acquir Immune Defic Syndr. 27: 426-31.
[11]	Galli M, Cozzi-Lepri A, Ridolfo A, Gervasoni C, Ravasio L, Corsico L, Gianelli E, Vaccarezza M, Vullo V, Cargnel A., 2002. Incidence of adipose tissue alterat ions in first-line antiretroviral therapy: theLipoICoNa Study."Arch Intern Med. 162(22): 2621-8.
[12]	Sulkowski MS, Thomas DL, Chaisson RE, Moore RD., 2000. Hepatotoxicity associated with antiretroviral therapy in adults infected with human immunodeficiency virus and the role of hepatitis C or B virus infection. JAMA. 283:74-80.
[13]	Aceti A, Pasquazzi C, Zechini B, De Bac C., 2002. Hepatotoxicity development during antiretroviral therapy containing protease inhibitors in patients with HIV : the role of hepatitis B and C virus infection. J Acquir Immune Defic Syndr. 29: 41-8.

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Marcellin Guiaro Ndoe, Armel Herve Nwabo Kamdje, Charles Fokunang Ntungwen, Michel Njan Nloga. (2015). Nutritional State Impact on the Liver Detoxification Function in Patients Infected by HIV under Antiretroviral Drugs at the Bertoua Day Hospital of Cameroon. Journal of Diseases and Medicinal Plants, 1(2), 37-41. https://doi.org/10.11648/j.jdmp.20150102.13

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Marcellin Guiaro Ndoe; Armel Herve Nwabo Kamdje; Charles Fokunang Ntungwen; Michel Njan Nloga. Nutritional State Impact on the Liver Detoxification Function in Patients Infected by HIV under Antiretroviral Drugs at the Bertoua Day Hospital of Cameroon. J. Dis. Med. Plants 2015, 1(2), 37-41. doi: 10.11648/j.jdmp.20150102.13

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AMA Style

Marcellin Guiaro Ndoe, Armel Herve Nwabo Kamdje, Charles Fokunang Ntungwen, Michel Njan Nloga. Nutritional State Impact on the Liver Detoxification Function in Patients Infected by HIV under Antiretroviral Drugs at the Bertoua Day Hospital of Cameroon. J Dis Med Plants. 2015;1(2):37-41. doi: 10.11648/j.jdmp.20150102.13

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@article{10.11648/j.jdmp.20150102.13,
  author = {Marcellin Guiaro Ndoe and Armel Herve Nwabo Kamdje and Charles Fokunang Ntungwen and Michel Njan Nloga},
  title = {Nutritional State Impact on the Liver Detoxification Function in Patients Infected by HIV under Antiretroviral Drugs at the Bertoua Day Hospital of Cameroon},
  journal = {Journal of Diseases and Medicinal Plants},
  volume = {1},
  number = {2},
  pages = {37-41},
  doi = {10.11648/j.jdmp.20150102.13},
  url = {https://doi.org/10.11648/j.jdmp.20150102.13},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jdmp.20150102.13},
  abstract = {The present study aimed at evaluating the nutritional state impact on liver detoxification function in patients infected by the human immunodeficiency virus under antiretroviral drugs. We performed a retrospective and prospective transversal survey on the patients infected by the human immunodeficiency virus, under antiretroviral drugs at the Bertoua day hospital. The retrospective period of our survey went from October 24, 2014 to February 24, 2014 (4 months) and the prospective shutter of the survey went from February 24, 2014 to August 24, 2014 (6 months), a total period of 10 months. We also analysed the socio-demographics parameters (Age and Sex), Biological parameters (HIV type, CD4, Transaminases) and the therapeutics parameters (Therapeutic protocol, Evolution). The hepatic affection has been judged by the remarkable increase of the rate of transaminases (>3N) and by the appearance of hypersensitivity signs (Skin rashes, Fever…). During this survey, 38 hepatic-toxicity cases caused by the intake of ARV drugs were collected. We included 12 men (31.58%) and 26 women (68.42%) with a sex-ratio of 0.46 in favor of the women. The average age was 45.68±13.13 year with age ranging between 10 to 65 years. Age group of 50 years and above was most represented with a percentage of 42.10. The majority of the patients were infected by the HIV 1 (86.85%) against 10.52% for the HIV 2 and 2.63% for the HIV 1+2. The most prescribed therapy was the association of 2 INTI+1 INNTI (Tenofovir+Lamivudine+Nevirapine) and the AIDS stage represented 7.89%. Prior to the antiretroviral therapy, the 38 patients had normal transaminases that followed modifications of the initial therapeutic protocol after a remarkable increase during the antiretroviral therapy. We noted during this survey that the hepatotoxicity intervention of our patients under ARV drugs was correlated to their Body Mass Index (BMI) that allowed us to evaluate the nutritional state of our patients. The intervention of the hepatotoxicity during the antiretroviral therapy, among the HIV patients having a good nutritional state (normal BMI), was very weak in the absence of the predisposing factors.},
 year = {2015}
}

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TY  - JOUR
T1  - Nutritional State Impact on the Liver Detoxification Function in Patients Infected by HIV under Antiretroviral Drugs at the Bertoua Day Hospital of Cameroon
AU  - Marcellin Guiaro Ndoe
AU  - Armel Herve Nwabo Kamdje
AU  - Charles Fokunang Ntungwen
AU  - Michel Njan Nloga
Y1  - 2015/06/23
PY  - 2015
N1  - https://doi.org/10.11648/j.jdmp.20150102.13
DO  - 10.11648/j.jdmp.20150102.13
T2  - Journal of Diseases and Medicinal Plants
JF  - Journal of Diseases and Medicinal Plants
JO  - Journal of Diseases and Medicinal Plants
SP  - 37
EP  - 41
PB  - Science Publishing Group
SN  - 2469-8210
UR  - https://doi.org/10.11648/j.jdmp.20150102.13
AB  - The present study aimed at evaluating the nutritional state impact on liver detoxification function in patients infected by the human immunodeficiency virus under antiretroviral drugs. We performed a retrospective and prospective transversal survey on the patients infected by the human immunodeficiency virus, under antiretroviral drugs at the Bertoua day hospital. The retrospective period of our survey went from October 24, 2014 to February 24, 2014 (4 months) and the prospective shutter of the survey went from February 24, 2014 to August 24, 2014 (6 months), a total period of 10 months. We also analysed the socio-demographics parameters (Age and Sex), Biological parameters (HIV type, CD4, Transaminases) and the therapeutics parameters (Therapeutic protocol, Evolution). The hepatic affection has been judged by the remarkable increase of the rate of transaminases (>3N) and by the appearance of hypersensitivity signs (Skin rashes, Fever…). During this survey, 38 hepatic-toxicity cases caused by the intake of ARV drugs were collected. We included 12 men (31.58%) and 26 women (68.42%) with a sex-ratio of 0.46 in favor of the women. The average age was 45.68±13.13 year with age ranging between 10 to 65 years. Age group of 50 years and above was most represented with a percentage of 42.10. The majority of the patients were infected by the HIV 1 (86.85%) against 10.52% for the HIV 2 and 2.63% for the HIV 1+2. The most prescribed therapy was the association of 2 INTI+1 INNTI (Tenofovir+Lamivudine+Nevirapine) and the AIDS stage represented 7.89%. Prior to the antiretroviral therapy, the 38 patients had normal transaminases that followed modifications of the initial therapeutic protocol after a remarkable increase during the antiretroviral therapy. We noted during this survey that the hepatotoxicity intervention of our patients under ARV drugs was correlated to their Body Mass Index (BMI) that allowed us to evaluate the nutritional state of our patients. The intervention of the hepatotoxicity during the antiretroviral therapy, among the HIV patients having a good nutritional state (normal BMI), was very weak in the absence of the predisposing factors.
VL  - 1
IS  - 2
ER  -

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Author Information

Marcellin Guiaro Ndoe

Department of Biomedical Sciences, Faculty of Science, University of Ngaoundere, Ngaoundere, Cameroon
Armel Herve Nwabo Kamdje

Department of Biomedical Sciences, Faculty of Science, University of Ngaoundere, Ngaoundere, Cameroon
Charles Fokunang Ntungwen

Faculty of Medicine and Biomedical Sciences, University of Yaounde I, Yaounde, Cameroon
Michel Njan Nloga

Department of Biological Sciences, Faculty of Science, University of Ngaoundere, Ngaoundere, Cameroon

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APA Style

Marcellin Guiaro Ndoe, Armel Herve Nwabo Kamdje, Charles Fokunang Ntungwen, Michel Njan Nloga. (2015). Nutritional State Impact on the Liver Detoxification Function in Patients Infected by HIV under Antiretroviral Drugs at the Bertoua Day Hospital of Cameroon. Journal of Diseases and Medicinal Plants, 1(2), 37-41. https://doi.org/10.11648/j.jdmp.20150102.13

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ACS Style

Marcellin Guiaro Ndoe; Armel Herve Nwabo Kamdje; Charles Fokunang Ntungwen; Michel Njan Nloga. Nutritional State Impact on the Liver Detoxification Function in Patients Infected by HIV under Antiretroviral Drugs at the Bertoua Day Hospital of Cameroon. J. Dis. Med. Plants 2015, 1(2), 37-41. doi: 10.11648/j.jdmp.20150102.13

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AMA Style

Marcellin Guiaro Ndoe, Armel Herve Nwabo Kamdje, Charles Fokunang Ntungwen, Michel Njan Nloga. Nutritional State Impact on the Liver Detoxification Function in Patients Infected by HIV under Antiretroviral Drugs at the Bertoua Day Hospital of Cameroon. J Dis Med Plants. 2015;1(2):37-41. doi: 10.11648/j.jdmp.20150102.13

Copy | Download

@article{10.11648/j.jdmp.20150102.13,
  author = {Marcellin Guiaro Ndoe and Armel Herve Nwabo Kamdje and Charles Fokunang Ntungwen and Michel Njan Nloga},
  title = {Nutritional State Impact on the Liver Detoxification Function in Patients Infected by HIV under Antiretroviral Drugs at the Bertoua Day Hospital of Cameroon},
  journal = {Journal of Diseases and Medicinal Plants},
  volume = {1},
  number = {2},
  pages = {37-41},
  doi = {10.11648/j.jdmp.20150102.13},
  url = {https://doi.org/10.11648/j.jdmp.20150102.13},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jdmp.20150102.13},
  abstract = {The present study aimed at evaluating the nutritional state impact on liver detoxification function in patients infected by the human immunodeficiency virus under antiretroviral drugs. We performed a retrospective and prospective transversal survey on the patients infected by the human immunodeficiency virus, under antiretroviral drugs at the Bertoua day hospital. The retrospective period of our survey went from October 24, 2014 to February 24, 2014 (4 months) and the prospective shutter of the survey went from February 24, 2014 to August 24, 2014 (6 months), a total period of 10 months. We also analysed the socio-demographics parameters (Age and Sex), Biological parameters (HIV type, CD4, Transaminases) and the therapeutics parameters (Therapeutic protocol, Evolution). The hepatic affection has been judged by the remarkable increase of the rate of transaminases (>3N) and by the appearance of hypersensitivity signs (Skin rashes, Fever…). During this survey, 38 hepatic-toxicity cases caused by the intake of ARV drugs were collected. We included 12 men (31.58%) and 26 women (68.42%) with a sex-ratio of 0.46 in favor of the women. The average age was 45.68±13.13 year with age ranging between 10 to 65 years. Age group of 50 years and above was most represented with a percentage of 42.10. The majority of the patients were infected by the HIV 1 (86.85%) against 10.52% for the HIV 2 and 2.63% for the HIV 1+2. The most prescribed therapy was the association of 2 INTI+1 INNTI (Tenofovir+Lamivudine+Nevirapine) and the AIDS stage represented 7.89%. Prior to the antiretroviral therapy, the 38 patients had normal transaminases that followed modifications of the initial therapeutic protocol after a remarkable increase during the antiretroviral therapy. We noted during this survey that the hepatotoxicity intervention of our patients under ARV drugs was correlated to their Body Mass Index (BMI) that allowed us to evaluate the nutritional state of our patients. The intervention of the hepatotoxicity during the antiretroviral therapy, among the HIV patients having a good nutritional state (normal BMI), was very weak in the absence of the predisposing factors.},
 year = {2015}
}

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TY  - JOUR
T1  - Nutritional State Impact on the Liver Detoxification Function in Patients Infected by HIV under Antiretroviral Drugs at the Bertoua Day Hospital of Cameroon
AU  - Marcellin Guiaro Ndoe
AU  - Armel Herve Nwabo Kamdje
AU  - Charles Fokunang Ntungwen
AU  - Michel Njan Nloga
Y1  - 2015/06/23
PY  - 2015
N1  - https://doi.org/10.11648/j.jdmp.20150102.13
DO  - 10.11648/j.jdmp.20150102.13
T2  - Journal of Diseases and Medicinal Plants
JF  - Journal of Diseases and Medicinal Plants
JO  - Journal of Diseases and Medicinal Plants
SP  - 37
EP  - 41
PB  - Science Publishing Group
SN  - 2469-8210
UR  - https://doi.org/10.11648/j.jdmp.20150102.13
AB  - The present study aimed at evaluating the nutritional state impact on liver detoxification function in patients infected by the human immunodeficiency virus under antiretroviral drugs. We performed a retrospective and prospective transversal survey on the patients infected by the human immunodeficiency virus, under antiretroviral drugs at the Bertoua day hospital. The retrospective period of our survey went from October 24, 2014 to February 24, 2014 (4 months) and the prospective shutter of the survey went from February 24, 2014 to August 24, 2014 (6 months), a total period of 10 months. We also analysed the socio-demographics parameters (Age and Sex), Biological parameters (HIV type, CD4, Transaminases) and the therapeutics parameters (Therapeutic protocol, Evolution). The hepatic affection has been judged by the remarkable increase of the rate of transaminases (>3N) and by the appearance of hypersensitivity signs (Skin rashes, Fever…). During this survey, 38 hepatic-toxicity cases caused by the intake of ARV drugs were collected. We included 12 men (31.58%) and 26 women (68.42%) with a sex-ratio of 0.46 in favor of the women. The average age was 45.68±13.13 year with age ranging between 10 to 65 years. Age group of 50 years and above was most represented with a percentage of 42.10. The majority of the patients were infected by the HIV 1 (86.85%) against 10.52% for the HIV 2 and 2.63% for the HIV 1+2. The most prescribed therapy was the association of 2 INTI+1 INNTI (Tenofovir+Lamivudine+Nevirapine) and the AIDS stage represented 7.89%. Prior to the antiretroviral therapy, the 38 patients had normal transaminases that followed modifications of the initial therapeutic protocol after a remarkable increase during the antiretroviral therapy. We noted during this survey that the hepatotoxicity intervention of our patients under ARV drugs was correlated to their Body Mass Index (BMI) that allowed us to evaluate the nutritional state of our patients. The intervention of the hepatotoxicity during the antiretroviral therapy, among the HIV patients having a good nutritional state (normal BMI), was very weak in the absence of the predisposing factors.
VL  - 1
IS  - 2
ER  -

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