Oxidative Role of HIV/AIDS: Antiretroviral Drugs and Medicinal Plants with Anti-HIV Activity

Franklin Nyenty Tabe; Nicolas Njintang Yanou; Armel Herve Nwabo Kamdje; Aurelie-Solange Agume Ntso

doi:doi:10.11648/j.jdmp.20150105.11

| Peer-Reviewed

Oxidative Role of HIV/AIDS: Antiretroviral Drugs and Medicinal Plants with Anti-HIV Activity

Franklin Nyenty Tabe, Nicolas Njintang Yanou, Armel Herve Nwabo Kamdje, Aurelie-Solange Agume Ntso

Published in Journal of Diseases and Medicinal Plants (Volume 1, Issue 5)

Received: 13 October 2015 Accepted: 22 October 2015 Published: 25 December 2015

Views: Downloads:

Download PDF

Share This Article

Twitter
Linked In
Facebook

Abstract

More than three decades after its outbreak, the Acquired Immune Deficiency Syndrome (AIDS) remains a great mystery because there is neither an existing vaccine against its causative agent (the human immune deficiency virus) nor a cure against it. Worst of all is the popular attention that is tuned to the AIDS virus, ignoring oxidative stress which is the major cause of mortality in HIV/AIDS as in many other chronic diseases. Antiretroviral drugs introduced in 1996 have been shown to increase oxidative stress among other drug-related complications. With these backdrops, an antioxidant therapy is necessary to accompany antiretroviral treatment without which its beneficial effects are null. The present review aims to discuss the Oxidative Role of HIV/AIDS and antiretroviral drugs as well as some plants that have recently been revealed to be rich sources of antioxidants.

Published in	Journal of Diseases and Medicinal Plants (Volume 1, Issue 5)
DOI	10.11648/j.jdmp.20150105.11
Page(s)	68-75
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2015. Published by Science Publishing Group

Keywords

Oxidative Stress, HIV/AIDS, Antiretroviral Drugs, Anti-HIV Plant Products

References

[1]	Biesinger T, Kimata JT. HIV-1 Transmission, Replication Fitness and Disease Progression. Virology: Research and Treatment 2008; 1: 49-63.
[2]	Website: http://www.medscape.com/viewarticle/584032.
[3]	Lohse N, Hansen AB, Pedersen G, et al. Survival of persons with and without HIV infection in Denmark, 1995-2005. Ann Intern Med 2007; 146(2): 87-95.
[4]	Park WB, Choe PG, Jo JH, et al. Tuberculosis manifested by immune reconstitution inflammatory syndrome during. HAART. AIDS 2007; 21(7): 875-77.
[5]	Bhaskaran K, Hamouda O, Sannes M, et al. CASCADE Collaboration. Changes in the risk of death after HIV seroconversion compared with mortality in the general population. JAMA 2008; 2: 300(1): 51-59.
[6]	Tedaldi EM, Absalon J, Thomas AJ, Shlay JC, van den Berg-Wolf M. Ethnicity, race, and gender. Differences in serious adverse events among participants in an antiretroviral initiation trial: results of CPCRA 058 (FIRST Study). J Acquir Immune Defic Syndr 2008; 47(4): 441-48.
[7]	Lizette G. D. V., Rosario G. H., Jorge P. A. 2013. Oxidative stress associated to disease progression and toxicity during antiretroviral therapy in Human Immunodeficiency Virus infection. Journal of Virology and Microbiology [online] 2013: 15. Available from: http://www.ibimapublishing.com/journals/JVM/jvm.html. DOI: 10.5171/2013.279685. [Accessed14th February 2014].
[8]	Abheri D. S., Anisur R. M., and Ghosh A. K. 2010. Free radicals and their role in different clinical conditions: An overview. International Journal of Pharmaceutical Sciences and Research 1(3): 185-192.
[9]	Noori S. 2012. An overview of oxidative stress and antioxidant defensive system. 1: 413. DOI: 10.4172/scientificreports.413.
[10]	Amit K., Priyadarsini K. I. 2011. Free radicals, oxidative stress and importance of antioxidants in human health. Journal of Medical Allied Sciences [online] 1(2): 53-60. Available from: www.jmas.in. [Accessed 31st March 2013].
[11]	Lien A P. H., Hua H., Chuong P. H. 2008. Free radicals, antioxidants in disease and health. Journal of Biomedical Sciences [online] 4(2): 89-96. available from: http://www.ijbs.org. [Accessed 1st November 2013].
[12]	Upma G., Anju J., Parul S., Sarita B., Rajiv G., Arvind S. (April-June 2012). Free radical status in retinopathy of prematurity. Indian Journal of Clinical Biochemistry 27(2): 196-199.
[13]	Gerhard Krauss. Biochemistry of signal transduction and regulation.3rd ed. Wiley-VCH Verlag. GmbH and Co. KGaA, Weinheim; 2003.
[14]	Manzoor A., Nida S., Tariq M., Naheed B., Shamshad A. (OctDec 2012). Evaluation of oxidative stress and DNA damage in benign prostatic hyperplasia patients and comparison with controls. Indian Journal of Clinical Biochemistry 27(4): 385-388.
[15]	Lizette G. D. V., Rosario G. H., Jorge P. A. 2013. Oxidative stress associated to disease progression and toxicity during antiretroviral therapy in Human Immunodeficiency Virus infection. Journal of Virology and Microbiology [online] 2013:15. Available from: http://www.ibimapublishing.com/journals/JVM/jvm.html. DOI: 10.5171/2013.279685. [Accessed14th February 2014].
[16]	Bo J., Alok R. K., Lynette K. R., Valeria Y. H., James H. Z., et al. 2010 October. Antiretroviral induce endothelial dysfunction via an oxidant-dependent pathway and promote neointimal hyperplasia. Toxicological Science 117(2): 524-536.
[17]	Anthony H. K., Ashok A. 2011. Oxidants and antioxidants in the pathogenesis of HIV/AIDS. The Open Reproductive Science Journal 3: 154-161. DOI: 10.1186/1742-6405-3-19. [Accessed 7th October 2013].
[18]	Seyed A. A., Seyedeh F. M., and Ebrahim B. 2012. Antioxidants: A few key points. Annals of Biological Research [online] 3(8): 3968-3977. Available from: http//www.scholarsresearchlibrary.com. [Accessed 14th June 2014].
[19]	Saikat S., Raja C., Sridhar C., Reddy Y. S. R., Biplab D. 2010. Free radicals, antioxidants, diseases and phytomedicines: Current status and future prospect. International Journal of Pharmaceutical Sciences Review and Research [online] 3(21): 091-100. Available from: http//www.globalresearchonline.net.
[20]	Erin E. B. and Julia L. B. 2009. Antioxidant activity of sulfur and selenium: A review of reactive oxygen species scavenging, glutathione peroxidase, and metal-binding antioxidant mechanisms. Cell Biochemistry and Biophysics 55: 1-23. DOI: 10.1007/s12013-009-9054-7.
[21]	Krishna P. B., Debasish B. and Govindasamy M. 2013. Synthetic glutathione peroxidase mimics: Effect of nucleophilicity of the aryl thiol cofactor on the antioxidant activity. Indian Journal of Chemistry 52: 1019-1025.
[22]	Maria L. C. 2010. An update of vitamin E, tocopherol and tocotrienol- perspectives: A review. Molecules [online] 15: 2103-2113. Available from: http//www.mdpi.com/jornal/molecules. DOI: 10.3390/molecules.15042103. [Accessed11th August 2014].
[23]	Aysun H. 2009. An overview of ascorbic acid biochemistry. Journal of Faculty of Pharmacy, Ankara 38(3): 233-255.
[24]	Vittorio C., Marzia P., Carolin C., Raffaella C., Fabio D. D., Giovanni P., et al. Phenolics in aging and neurodegenerative disorders. In: Cesar G. Fraga (Ed.). Plant phenolics and human health. Hoboken, New Jersey: John Wiley and sons Inc.: 2010. p. 427-444.
[25]	James H. D. 2012. Phytochemicals: Extraction Methods, Basic Structures and Mode of Action as Potential Chemotherapeutic Agents, Phytochemicals-A Global Perspective of Their Role in Nutrition and Health, Dr. Venketshwer Rao (Ed.), ISBN: 978- 953-51-0296-0, InTech, Available from: http//www.intecopen.com/books/phytochemicals-a-globalperspective-of-their-role-in-nutrition-and-health/phytochemicalsextraction-methods-basic-structures-and-mode-of-action-aspotential-chemotherapeutic-agents.
[26]	Satyanand T., Gunjan S., Anamika S., Gulshan A. 2010. Phytochemicals as candidate therapeutics: An overview. International Journal of Pharmaceutical Sciences Review and Research [online] 3(1): 53-55. Available from: http//www.globalresearchonline.net. [Accessed 11th August 2014].
[27]	Siwang Y., Ka L. C., Wenge L., and Ah-ng K. Plant phenolic compounds: Modulation of cytoprotective enzymes and Nrf2/ARE signaling. In: Cesar G. Fraga (ed.) Plant phenolics and human health. Hoboken, New Jersey: John Wiley and sons Inc.; 2010. P. 402-409.
[28]	Sanda V. K. B. B., Maja B. S. and Marija B. 2012. Plant polyphenols as antioxidants Influencing the Human Health, Phytochemicals as Nutraceuticals-Global Approaches to Their Role in Nutrition and Health, Dr. Venketeshwer Rao (Ed.), ISBN:978-953-51-0203-8, InTech, Available from: http//www.intechopen.com/books/phytochemicals-asnutraceuticals-global-approaches-to-their-role-in-nutrition-andhealth/plant-polyphenols-as-antioxidants-influencing-the-humanhealth.
[29]	Tapas A. R., Sakarkar D. M. and Kakde R. B. 2008. Flavonoids as nutraceuticals: A review. Tropical Journal of Pharmaceutical Research [online] 7(3): 1089-1099. Available from: http//www.tjpr.org.
[30]	Zuzana K. 2011. Toxicological aspects of the use of phenolic compounds in disease prevention. Interdisciplinary Toxicology [online] 4(4): 173-183. Available from: http//www.intertox.sav.sk and http//www.versita.com/science/medicine/it/ DOI: 10.2478/v10102-011-0027-5. [Accessed 11th August 2014].
[31]	Evelyn B. R., Maxima E. F., Delia B. R. A. and Jaime A. F. 2006. Phytochemicals and functional foods. Current situation and prospect for developing countries. Segurança Alímentar e Nutricional, Campinas 13(1): 1-22.
[32]	Indu B. J. and Alan C. Dietary flavonoids and phenolic compounds. In: Cesar G. Fraga(Ed.). Plant phenolics and human health. Hoboken, New Jersey: John Wiley and sons Inc.: 2010. p. 1-39.
[33]	Cesar G. F., Gulcin S. C., and Monica G. Biochemical actions of plant phenolics compounds: Thermodynamic and kinetic aspects. In: Cesar G. Fraga (ed.) Plant phenolics and human health. Hoboken, New Jersey: John Wiley and sons Inc.; 2010. P. 91-103.
[34]	Harleen K. S., Bimlesh K., Sunil P., Prashant T., Manoj S., Pardeep S. 2011. A review of phytochemistry and pharmacology of flavonoids. International Pharmaceutica Sciencia [online] 1(1): 25-41. Available from: http//www.ipharmsciencia.com.
[35]	Mohamed A. H. 2011. A convenient mechanism for the free radical scavenging activity of resveratrol. International Journal of Phytomedicine [online] 3: 459-469. Available from: http//www.arjournals.org/index.php/ijpm/index. [Accessed 14th June 2014].
[36]	Ajit B. P. and Asha S. J. 2013. Flavonoids, an antioxidant: A review. International Journal of Pharmaceutical and Biological Sciences Research and Development [online] 1(2): 07-20. Available from: http://www.ijpbsrd.com. [Accessed 14th June 2014].
[37]	Bo J., Alok R. K., Lynette K. R., Valeria Y. H., James H. Z., et al. 2010 October. Antiretroviral induce endothelial dysfunction via an oxidant-dependent pathway and promote neointimal hyperplasia. Toxicological Science 117(2): 524-536.
[38]	Singh J, Monika, Kumar A, Kumar V, Sethi JS. Medicinal Plants with anti- HIV activity. International Journal of Natural Product Science, 2011; 1: 1-8.

Cite This Article

Plain Text BibTeX RIS

APA Style

Franklin Nyenty Tabe, Nicolas Njintang Yanou, Armel Herve Nwabo Kamdje, Aurelie-Solange Agume Ntso. (2015). Oxidative Role of HIV/AIDS: Antiretroviral Drugs and Medicinal Plants with Anti-HIV Activity. Journal of Diseases and Medicinal Plants, 1(5), 68-75. https://doi.org/10.11648/j.jdmp.20150105.11

Copy | Download

ACS Style

Franklin Nyenty Tabe; Nicolas Njintang Yanou; Armel Herve Nwabo Kamdje; Aurelie-Solange Agume Ntso. Oxidative Role of HIV/AIDS: Antiretroviral Drugs and Medicinal Plants with Anti-HIV Activity. J. Dis. Med. Plants 2015, 1(5), 68-75. doi: 10.11648/j.jdmp.20150105.11

Copy | Download

AMA Style

Franklin Nyenty Tabe, Nicolas Njintang Yanou, Armel Herve Nwabo Kamdje, Aurelie-Solange Agume Ntso. Oxidative Role of HIV/AIDS: Antiretroviral Drugs and Medicinal Plants with Anti-HIV Activity. J Dis Med Plants. 2015;1(5):68-75. doi: 10.11648/j.jdmp.20150105.11

Copy | Download

@article{10.11648/j.jdmp.20150105.11,
  author = {Franklin Nyenty Tabe and Nicolas Njintang Yanou and Armel Herve Nwabo Kamdje and Aurelie-Solange Agume Ntso},
  title = {Oxidative Role of HIV/AIDS: Antiretroviral Drugs and Medicinal Plants with Anti-HIV Activity},
  journal = {Journal of Diseases and Medicinal Plants},
  volume = {1},
  number = {5},
  pages = {68-75},
  doi = {10.11648/j.jdmp.20150105.11},
  url = {https://doi.org/10.11648/j.jdmp.20150105.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jdmp.20150105.11},
  abstract = {More than three decades after its outbreak, the Acquired Immune Deficiency Syndrome (AIDS) remains a great mystery because there is neither an existing vaccine against its causative agent (the human immune deficiency virus) nor a cure against it. Worst of all is the popular attention that is tuned to the AIDS virus, ignoring oxidative stress which is the major cause of mortality in HIV/AIDS as in many other chronic diseases. Antiretroviral drugs introduced in 1996 have been shown to increase oxidative stress among other drug-related complications. With these backdrops, an antioxidant therapy is necessary to accompany antiretroviral treatment without which its beneficial effects are null. The present review aims to discuss the Oxidative Role of HIV/AIDS and antiretroviral drugs as well as some plants that have recently been revealed to be rich sources of antioxidants.},
 year = {2015}
}

Copy | Download

TY  - JOUR
T1  - Oxidative Role of HIV/AIDS: Antiretroviral Drugs and Medicinal Plants with Anti-HIV Activity
AU  - Franklin Nyenty Tabe
AU  - Nicolas Njintang Yanou
AU  - Armel Herve Nwabo Kamdje
AU  - Aurelie-Solange Agume Ntso
Y1  - 2015/12/25
PY  - 2015
N1  - https://doi.org/10.11648/j.jdmp.20150105.11
DO  - 10.11648/j.jdmp.20150105.11
T2  - Journal of Diseases and Medicinal Plants
JF  - Journal of Diseases and Medicinal Plants
JO  - Journal of Diseases and Medicinal Plants
SP  - 68
EP  - 75
PB  - Science Publishing Group
SN  - 2469-8210
UR  - https://doi.org/10.11648/j.jdmp.20150105.11
AB  - More than three decades after its outbreak, the Acquired Immune Deficiency Syndrome (AIDS) remains a great mystery because there is neither an existing vaccine against its causative agent (the human immune deficiency virus) nor a cure against it. Worst of all is the popular attention that is tuned to the AIDS virus, ignoring oxidative stress which is the major cause of mortality in HIV/AIDS as in many other chronic diseases. Antiretroviral drugs introduced in 1996 have been shown to increase oxidative stress among other drug-related complications. With these backdrops, an antioxidant therapy is necessary to accompany antiretroviral treatment without which its beneficial effects are null. The present review aims to discuss the Oxidative Role of HIV/AIDS and antiretroviral drugs as well as some plants that have recently been revealed to be rich sources of antioxidants.
VL  - 1
IS  - 5
ER  -

Copy | Download

Author Information

Franklin Nyenty Tabe

Department of Biomedical Science, Faculty of Science, University of Ngaoundere, Adamawa Region, Cameroon
Nicolas Njintang Yanou

Department of Biomedical Science, Faculty of Science, University of Ngaoundere, Adamawa Region, Cameroon
Armel Herve Nwabo Kamdje

Department of Biomedical Science, Faculty of Science, University of Ngaoundere, Adamawa Region, Cameroon
Aurelie-Solange Agume Ntso

The Adamawa Regional Hospital, Ngaoundere, Cameroon

Download PDF

Sections

Plain Text BibTeX RIS

APA Style

Franklin Nyenty Tabe, Nicolas Njintang Yanou, Armel Herve Nwabo Kamdje, Aurelie-Solange Agume Ntso. (2015). Oxidative Role of HIV/AIDS: Antiretroviral Drugs and Medicinal Plants with Anti-HIV Activity. Journal of Diseases and Medicinal Plants, 1(5), 68-75. https://doi.org/10.11648/j.jdmp.20150105.11

Copy | Download

ACS Style

Franklin Nyenty Tabe; Nicolas Njintang Yanou; Armel Herve Nwabo Kamdje; Aurelie-Solange Agume Ntso. Oxidative Role of HIV/AIDS: Antiretroviral Drugs and Medicinal Plants with Anti-HIV Activity. J. Dis. Med. Plants 2015, 1(5), 68-75. doi: 10.11648/j.jdmp.20150105.11

Copy | Download

AMA Style

Franklin Nyenty Tabe, Nicolas Njintang Yanou, Armel Herve Nwabo Kamdje, Aurelie-Solange Agume Ntso. Oxidative Role of HIV/AIDS: Antiretroviral Drugs and Medicinal Plants with Anti-HIV Activity. J Dis Med Plants. 2015;1(5):68-75. doi: 10.11648/j.jdmp.20150105.11

Copy | Download

@article{10.11648/j.jdmp.20150105.11,
  author = {Franklin Nyenty Tabe and Nicolas Njintang Yanou and Armel Herve Nwabo Kamdje and Aurelie-Solange Agume Ntso},
  title = {Oxidative Role of HIV/AIDS: Antiretroviral Drugs and Medicinal Plants with Anti-HIV Activity},
  journal = {Journal of Diseases and Medicinal Plants},
  volume = {1},
  number = {5},
  pages = {68-75},
  doi = {10.11648/j.jdmp.20150105.11},
  url = {https://doi.org/10.11648/j.jdmp.20150105.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jdmp.20150105.11},
  abstract = {More than three decades after its outbreak, the Acquired Immune Deficiency Syndrome (AIDS) remains a great mystery because there is neither an existing vaccine against its causative agent (the human immune deficiency virus) nor a cure against it. Worst of all is the popular attention that is tuned to the AIDS virus, ignoring oxidative stress which is the major cause of mortality in HIV/AIDS as in many other chronic diseases. Antiretroviral drugs introduced in 1996 have been shown to increase oxidative stress among other drug-related complications. With these backdrops, an antioxidant therapy is necessary to accompany antiretroviral treatment without which its beneficial effects are null. The present review aims to discuss the Oxidative Role of HIV/AIDS and antiretroviral drugs as well as some plants that have recently been revealed to be rich sources of antioxidants.},
 year = {2015}
}

Copy | Download

TY  - JOUR
T1  - Oxidative Role of HIV/AIDS: Antiretroviral Drugs and Medicinal Plants with Anti-HIV Activity
AU  - Franklin Nyenty Tabe
AU  - Nicolas Njintang Yanou
AU  - Armel Herve Nwabo Kamdje
AU  - Aurelie-Solange Agume Ntso
Y1  - 2015/12/25
PY  - 2015
N1  - https://doi.org/10.11648/j.jdmp.20150105.11
DO  - 10.11648/j.jdmp.20150105.11
T2  - Journal of Diseases and Medicinal Plants
JF  - Journal of Diseases and Medicinal Plants
JO  - Journal of Diseases and Medicinal Plants
SP  - 68
EP  - 75
PB  - Science Publishing Group
SN  - 2469-8210
UR  - https://doi.org/10.11648/j.jdmp.20150105.11
AB  - More than three decades after its outbreak, the Acquired Immune Deficiency Syndrome (AIDS) remains a great mystery because there is neither an existing vaccine against its causative agent (the human immune deficiency virus) nor a cure against it. Worst of all is the popular attention that is tuned to the AIDS virus, ignoring oxidative stress which is the major cause of mortality in HIV/AIDS as in many other chronic diseases. Antiretroviral drugs introduced in 1996 have been shown to increase oxidative stress among other drug-related complications. With these backdrops, an antioxidant therapy is necessary to accompany antiretroviral treatment without which its beneficial effects are null. The present review aims to discuss the Oxidative Role of HIV/AIDS and antiretroviral drugs as well as some plants that have recently been revealed to be rich sources of antioxidants.
VL  - 1
IS  - 5
ER  -

Copy | Download