Mostueatecine A and B: Two Indole Alkaloids and Mostueatecine C, One Triterpene from <i>Mostuea batesii</i>

Gompe Eric Gustave; Ouahouo Wache Blandine Marlyse; Mkounga Pierre; Tabouguia Merveille; Assob Nguedia Jules; Clement Fotie Jean; Nkengfack Augustin Ephrem

doi:doi:10.11648/j.jdmp.20160206.11

Mostueatecine A and B: Two Indole Alkaloids and Mostueatecine C, One Triterpene from Mostuea batesii

Gompe Eric Gustave, Ouahouo Wache Blandine Marlyse, Mkounga Pierre, Tabouguia Merveille, Assob Nguedia Jules, Clement Fotie Jean, Nkengfack Augustin Ephrem

Published in Journal of Diseases and Medicinal Plants (Volume 2, Issue 6)

Received: 19 July 2016 Accepted: 25 August 2016 Published: 3 November 2016

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Abstract

Two new indole alkaloid derivatives namely Mostueatecine A (1), Mostueatecine B (2) and one new triterpene derivative Mostueatecine C (3) were isolated from the stem and leaves of Mostuea batesii, along with five known compounds: Camptothecine (4), β-amyrin-3-O-glucopyranoside (5), Oleanolic acid (6), 2α,3α,19α-trihydroxy-24-norurs-4(23),12-dien-28-oic acid (7) and Saccharose(8). The structures of these compounds were elucidated using a detailed analysis of their HRESI-MS, 1D and 2D NMR spectroscopic data. Some of these compounds were evaluated in vitro for their antimicrobial activities against a wide range of microorganisms. The results showed that none of them possess noticeable activity.

Published in	Journal of Diseases and Medicinal Plants (Volume 2, Issue 6)
DOI	10.11648/j.jdmp.20160206.11
Page(s)	60-66
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2016. Published by Science Publishing Group

Keywords

Mostuea batesii, Loganiaceae, Indolic Alkaloids, Mostueatecine, Triterpenoids, Antimicrobial Activity

References

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[4]	Neuwinger, H. D.; African traditional medicine: a dictionary of plant use and applications. Med. Pharm. Scientific, Stuttgart, Germany. 589. 2000.
[5]	Dai, J. R.; Hallock, Y. F.; Cardellina, J. H.; Boyd, M. R.; 20-O-ßGlucopyranosylcamptothecin from Mostueabrunonis: A potential camptothecin pro-drug with improved solubility. J. Nat. Prod. 62: 1427-1429, 1999.
[6]	Dzoyem, J. P.; Tangmouo, J. G.; Lonsi, D.; Etoa, F. X.; Lohoue, P. J.; In vitro. Antifungal Activity of extract and plumbagin from Diospyros crassIfloraHiern (Ebenaceae) Phytoter. Res. 14: 112 2007.
[7]	Sun, Y. N.; Wang, C. L.; Zhang, N.; Wang, Z.; Liu, Z. L.; Liu, J. L.; Synthesis of tetrahydro-β-carbolinesfromphthalic anhydrides and tryptamineChinese Chemical Letters 25. 1503–1506. 2014
[8]	Xuan, W. D.; Chen, H. S.; Du, J. L.; Liang, S.; Li, T. Z.; Cai, D. G.; Two new indole alkaloids from Nauclea officinalis. Journal of Asian Natural Products Research; 8: 719-722. 2008.
[9]	Sun, J.; Lou, H.; Dai, S.; Xu, H.; Zhao, F.; Liu K. indole alkaloids from Nauclea officinalis with weak antimalarial activity. Phytochemistry 69, 1405-1419. 2007.
[10]	Wang, M.; Kikuzaki, H.; Csiszar, K.; Boyd, C. D.; Maunakea, A.; Fong, S. F.; Ghai, G.; Rosen, R. T.; Nakatani, N.; Ho, C. T.Novel trisaccharide fatty acid ester identified from the fruits of Morinda citrifolia (Noni). J. Agric. Food Chem., 47(12): 4880. 1999.
[11]	Noaki, K.; Hideki, O.;Fukushi, E.; Shuichi, O.; Kawa, J. Structural analysis of two trisaccharides isolated from fermented beverage of plant extract, Open Geoscience 1. 25-30. 2008.
[12]	Rao, S. C.; Banji1, D.; Sandhya, S.; Mahesh, V. A study on the nutraceuticals from the genus Rumex Hygeia. J. D. Med. 3 (1), 2011, 76-88.
[13]	Mahato, S. B; andKundu, A. P. 13C NMR spectra of pentacyclic triterpenoids a compilation and some salient features. Phytochemistry. 37, (6), 1517-1575. 1994.
[14]	Fabry, W.; Okemo, P. O.; Ansorg, R. Antibacterial activity of East African medicinal plants. Journal of Ethnopharmacology. 60: 79-84. 1998.
[15]	Njimoh, D. L.; Assob, J. C.; Mokake, S. E.; Nyahalah, D. J.; Yinda, C. K.; Sandjon, B. Antimicrobial activities of a plethora of medicinal plant extracts and hydrolates against human pathogens and their potential to reverse antibiotic resistance. International Journal of Microbiology: 15. 2015.

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APA Style

Gompe Eric Gustave, Ouahouo Wache Blandine Marlyse, Mkounga Pierre, Tabouguia Merveille, Assob Nguedia Jules, et al. (2016). Mostueatecine A and B: Two Indole Alkaloids and Mostueatecine C, One Triterpene from Mostuea batesii. Journal of Diseases and Medicinal Plants, 2(6), 60-66. https://doi.org/10.11648/j.jdmp.20160206.11

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ACS Style

Gompe Eric Gustave; Ouahouo Wache Blandine Marlyse; Mkounga Pierre; Tabouguia Merveille; Assob Nguedia Jules, et al. Mostueatecine A and B: Two Indole Alkaloids and Mostueatecine C, One Triterpene from Mostuea batesii. J. Dis. Med. Plants 2016, 2(6), 60-66. doi: 10.11648/j.jdmp.20160206.11

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AMA Style

Gompe Eric Gustave, Ouahouo Wache Blandine Marlyse, Mkounga Pierre, Tabouguia Merveille, Assob Nguedia Jules, et al. Mostueatecine A and B: Two Indole Alkaloids and Mostueatecine C, One Triterpene from Mostuea batesii. J Dis Med Plants. 2016;2(6):60-66. doi: 10.11648/j.jdmp.20160206.11

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@article{10.11648/j.jdmp.20160206.11,
  author = {Gompe Eric Gustave and Ouahouo Wache Blandine Marlyse and Mkounga Pierre and Tabouguia Merveille and Assob Nguedia Jules and Clement Fotie Jean and Nkengfack Augustin Ephrem},
  title = {Mostueatecine A and B: Two Indole Alkaloids and Mostueatecine C, One Triterpene from Mostuea batesii},
  journal = {Journal of Diseases and Medicinal Plants},
  volume = {2},
  number = {6},
  pages = {60-66},
  doi = {10.11648/j.jdmp.20160206.11},
  url = {https://doi.org/10.11648/j.jdmp.20160206.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jdmp.20160206.11},
  abstract = {Two new indole alkaloid derivatives namely Mostueatecine A (1), Mostueatecine B (2) and one new triterpene derivative Mostueatecine C (3) were isolated from the stem and leaves of Mostuea batesii, along with five known compounds: Camptothecine (4), β-amyrin-3-O-glucopyranoside (5), Oleanolic acid (6), 2α,3α,19α-trihydroxy-24-norurs-4(23),12-dien-28-oic acid (7) and Saccharose(8). The structures of these compounds were elucidated using a detailed analysis of their HRESI-MS, 1D and 2D NMR spectroscopic data. Some of these compounds were evaluated in vitro for their antimicrobial activities against a wide range of microorganisms. The results showed that none of them possess noticeable activity.},
 year = {2016}
}

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TY  - JOUR
T1  - Mostueatecine A and B: Two Indole Alkaloids and Mostueatecine C, One Triterpene from Mostuea batesii
AU  - Gompe Eric Gustave
AU  - Ouahouo Wache Blandine Marlyse
AU  - Mkounga Pierre
AU  - Tabouguia Merveille
AU  - Assob Nguedia Jules
AU  - Clement Fotie Jean
AU  - Nkengfack Augustin Ephrem
Y1  - 2016/11/03
PY  - 2016
N1  - https://doi.org/10.11648/j.jdmp.20160206.11
DO  - 10.11648/j.jdmp.20160206.11
T2  - Journal of Diseases and Medicinal Plants
JF  - Journal of Diseases and Medicinal Plants
JO  - Journal of Diseases and Medicinal Plants
SP  - 60
EP  - 66
PB  - Science Publishing Group
SN  - 2469-8210
UR  - https://doi.org/10.11648/j.jdmp.20160206.11
AB  - Two new indole alkaloid derivatives namely Mostueatecine A (1), Mostueatecine B (2) and one new triterpene derivative Mostueatecine C (3) were isolated from the stem and leaves of Mostuea batesii, along with five known compounds: Camptothecine (4), β-amyrin-3-O-glucopyranoside (5), Oleanolic acid (6), 2α,3α,19α-trihydroxy-24-norurs-4(23),12-dien-28-oic acid (7) and Saccharose(8). The structures of these compounds were elucidated using a detailed analysis of their HRESI-MS, 1D and 2D NMR spectroscopic data. Some of these compounds were evaluated in vitro for their antimicrobial activities against a wide range of microorganisms. The results showed that none of them possess noticeable activity.
VL  - 2
IS  - 6
ER  -

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Author Information

Gompe Eric Gustave

Department of Organic chemistry Faculty of Science University of Yaounde I, Yaounde, Cameroon
Ouahouo Wache Blandine Marlyse

Department of Organic chemistry Faculty of Science University of Yaounde I, Yaounde, Cameroon
Mkounga Pierre

Department of Organic chemistry Faculty of Science University of Yaounde I, Yaounde, Cameroon
Tabouguia Merveille

Department of Medical Laboratory Sciences, Faculty of health Sciences Laboratory, University of Buea, SW Region, Cameroon
Assob Nguedia Jules

Department of Medical Laboratory Sciences, Faculty of health Sciences Laboratory, University of Buea, SW Region, Cameroon
Clement Fotie Jean

Department of Chemistry and Physics Southeastern Louisiana University, Hammond, USA
Nkengfack Augustin Ephrem

Department of Organic chemistry Faculty of Science University of Yaounde I, Yaounde, Cameroon

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APA Style

Gompe Eric Gustave, Ouahouo Wache Blandine Marlyse, Mkounga Pierre, Tabouguia Merveille, Assob Nguedia Jules, et al. (2016). Mostueatecine A and B: Two Indole Alkaloids and Mostueatecine C, One Triterpene from Mostuea batesii. Journal of Diseases and Medicinal Plants, 2(6), 60-66. https://doi.org/10.11648/j.jdmp.20160206.11

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ACS Style

Gompe Eric Gustave; Ouahouo Wache Blandine Marlyse; Mkounga Pierre; Tabouguia Merveille; Assob Nguedia Jules, et al. Mostueatecine A and B: Two Indole Alkaloids and Mostueatecine C, One Triterpene from Mostuea batesii. J. Dis. Med. Plants 2016, 2(6), 60-66. doi: 10.11648/j.jdmp.20160206.11

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AMA Style

Gompe Eric Gustave, Ouahouo Wache Blandine Marlyse, Mkounga Pierre, Tabouguia Merveille, Assob Nguedia Jules, et al. Mostueatecine A and B: Two Indole Alkaloids and Mostueatecine C, One Triterpene from Mostuea batesii. J Dis Med Plants. 2016;2(6):60-66. doi: 10.11648/j.jdmp.20160206.11

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@article{10.11648/j.jdmp.20160206.11,
  author = {Gompe Eric Gustave and Ouahouo Wache Blandine Marlyse and Mkounga Pierre and Tabouguia Merveille and Assob Nguedia Jules and Clement Fotie Jean and Nkengfack Augustin Ephrem},
  title = {Mostueatecine A and B: Two Indole Alkaloids and Mostueatecine C, One Triterpene from Mostuea batesii},
  journal = {Journal of Diseases and Medicinal Plants},
  volume = {2},
  number = {6},
  pages = {60-66},
  doi = {10.11648/j.jdmp.20160206.11},
  url = {https://doi.org/10.11648/j.jdmp.20160206.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jdmp.20160206.11},
  abstract = {Two new indole alkaloid derivatives namely Mostueatecine A (1), Mostueatecine B (2) and one new triterpene derivative Mostueatecine C (3) were isolated from the stem and leaves of Mostuea batesii, along with five known compounds: Camptothecine (4), β-amyrin-3-O-glucopyranoside (5), Oleanolic acid (6), 2α,3α,19α-trihydroxy-24-norurs-4(23),12-dien-28-oic acid (7) and Saccharose(8). The structures of these compounds were elucidated using a detailed analysis of their HRESI-MS, 1D and 2D NMR spectroscopic data. Some of these compounds were evaluated in vitro for their antimicrobial activities against a wide range of microorganisms. The results showed that none of them possess noticeable activity.},
 year = {2016}
}

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TY  - JOUR
T1  - Mostueatecine A and B: Two Indole Alkaloids and Mostueatecine C, One Triterpene from Mostuea batesii
AU  - Gompe Eric Gustave
AU  - Ouahouo Wache Blandine Marlyse
AU  - Mkounga Pierre
AU  - Tabouguia Merveille
AU  - Assob Nguedia Jules
AU  - Clement Fotie Jean
AU  - Nkengfack Augustin Ephrem
Y1  - 2016/11/03
PY  - 2016
N1  - https://doi.org/10.11648/j.jdmp.20160206.11
DO  - 10.11648/j.jdmp.20160206.11
T2  - Journal of Diseases and Medicinal Plants
JF  - Journal of Diseases and Medicinal Plants
JO  - Journal of Diseases and Medicinal Plants
SP  - 60
EP  - 66
PB  - Science Publishing Group
SN  - 2469-8210
UR  - https://doi.org/10.11648/j.jdmp.20160206.11
AB  - Two new indole alkaloid derivatives namely Mostueatecine A (1), Mostueatecine B (2) and one new triterpene derivative Mostueatecine C (3) were isolated from the stem and leaves of Mostuea batesii, along with five known compounds: Camptothecine (4), β-amyrin-3-O-glucopyranoside (5), Oleanolic acid (6), 2α,3α,19α-trihydroxy-24-norurs-4(23),12-dien-28-oic acid (7) and Saccharose(8). The structures of these compounds were elucidated using a detailed analysis of their HRESI-MS, 1D and 2D NMR spectroscopic data. Some of these compounds were evaluated in vitro for their antimicrobial activities against a wide range of microorganisms. The results showed that none of them possess noticeable activity.
VL  - 2
IS  - 6
ER  -

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