This study was conducted to clarify the potential role of AGE against damages induced in rats due to exposure to gamma radiation. Adult male albino rats (214-230g). Eight groups, five healthy male rats each were used (20 irradiated and 20 Sham Irradiated), among which some were receiving via gavages distilled water, the others AGE at different doses (25 mg/kg and 50 mg/kg) and the rest vitamin E+Alpha Lipoïc Acid. Blood samples were collected at day 8 post irradiation for biochemical assay. Exposure of rats to gamma radiation caused a significant increase in the level of total cholesterol (TC), triglycerides (TG), LDL-Cholesterol, Malondialdehyde (MDA), Nitrite (NO2-), Creatinine and AST, ALT, ALP and Bilirubin (Total Serum Bilirubin, Direct Bilirubin and Unconjugated Bilirubin)while a significant decrease was recorded in HDL-Cholesterol, serum total proteins, glutathione content (GSH), superoxide dismutase (SOD), catalase (CAT) activities and total protein level in organs tissues. In rats treated with AGE then exposed to radiation, the results showed an improvement in all previous parameters. It could be concluded that AGE might reduce the biological hazards in rats induced by gamma irradiation.
| Published in | Journal of Diseases and Medicinal Plants (Volume 2, Issue 6) |
| DOI | 10.11648/j.jdmp.20160206.16 |
| Page(s) | 96-116 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2017. Published by Science Publishing Group |
γ-Radiation, Biochemical Disorders, Age, Antioxidant Enzymes, Rats
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APA Style
Kouam Foubi Brice Bertrand, Chuisseu Djamen Dieudonné Pascal, Dzeufiet Djomeni Paul Désiré, Mopia Foubi Myriam Arielle, Samba Ngano Odette, et al. (2017). Role of Aged Garlic Extract Against Radiation Induced Oxidative Stress Associated with Some Biochemical Disorders in Male Albino Rats. Journal of Diseases and Medicinal Plants, 2(6), 96-116. https://doi.org/10.11648/j.jdmp.20160206.16
ACS Style
Kouam Foubi Brice Bertrand; Chuisseu Djamen Dieudonné Pascal; Dzeufiet Djomeni Paul Désiré; Mopia Foubi Myriam Arielle; Samba Ngano Odette, et al. Role of Aged Garlic Extract Against Radiation Induced Oxidative Stress Associated with Some Biochemical Disorders in Male Albino Rats. J. Dis. Med. Plants 2017, 2(6), 96-116. doi: 10.11648/j.jdmp.20160206.16
AMA Style
Kouam Foubi Brice Bertrand, Chuisseu Djamen Dieudonné Pascal, Dzeufiet Djomeni Paul Désiré, Mopia Foubi Myriam Arielle, Samba Ngano Odette, et al. Role of Aged Garlic Extract Against Radiation Induced Oxidative Stress Associated with Some Biochemical Disorders in Male Albino Rats. J Dis Med Plants. 2017;2(6):96-116. doi: 10.11648/j.jdmp.20160206.16
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Download@article{10.11648/j.jdmp.20160206.16,
author = {Kouam Foubi Brice Bertrand and Chuisseu Djamen Dieudonné Pascal and Dzeufiet Djomeni Paul Désiré and Mopia Foubi Myriam Arielle and Samba Ngano Odette and Mouelle Sone and Tiedeu Alain Bertin and Gonsu Fotsin Joseph},
title = {Role of Aged Garlic Extract Against Radiation Induced Oxidative Stress Associated with Some Biochemical Disorders in Male Albino Rats},
journal = {Journal of Diseases and Medicinal Plants},
volume = {2},
number = {6},
pages = {96-116},
doi = {10.11648/j.jdmp.20160206.16},
url = {https://doi.org/10.11648/j.jdmp.20160206.16},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jdmp.20160206.16},
abstract = {This study was conducted to clarify the potential role of AGE against damages induced in rats due to exposure to gamma radiation. Adult male albino rats (214-230g). Eight groups, five healthy male rats each were used (20 irradiated and 20 Sham Irradiated), among which some were receiving via gavages distilled water, the others AGE at different doses (25 mg/kg and 50 mg/kg) and the rest vitamin E+Alpha Lipoïc Acid. Blood samples were collected at day 8 post irradiation for biochemical assay. Exposure of rats to gamma radiation caused a significant increase in the level of total cholesterol (TC), triglycerides (TG), LDL-Cholesterol, Malondialdehyde (MDA), Nitrite (NO2-), Creatinine and AST, ALT, ALP and Bilirubin (Total Serum Bilirubin, Direct Bilirubin and Unconjugated Bilirubin)while a significant decrease was recorded in HDL-Cholesterol, serum total proteins, glutathione content (GSH), superoxide dismutase (SOD), catalase (CAT) activities and total protein level in organs tissues. In rats treated with AGE then exposed to radiation, the results showed an improvement in all previous parameters. It could be concluded that AGE might reduce the biological hazards in rats induced by gamma irradiation.},
year = {2017}
}
TY - JOUR T1 - Role of Aged Garlic Extract Against Radiation Induced Oxidative Stress Associated with Some Biochemical Disorders in Male Albino Rats AU - Kouam Foubi Brice Bertrand AU - Chuisseu Djamen Dieudonné Pascal AU - Dzeufiet Djomeni Paul Désiré AU - Mopia Foubi Myriam Arielle AU - Samba Ngano Odette AU - Mouelle Sone AU - Tiedeu Alain Bertin AU - Gonsu Fotsin Joseph Y1 - 2017/01/11 PY - 2017 N1 - https://doi.org/10.11648/j.jdmp.20160206.16 DO - 10.11648/j.jdmp.20160206.16 T2 - Journal of Diseases and Medicinal Plants JF - Journal of Diseases and Medicinal Plants JO - Journal of Diseases and Medicinal Plants SP - 96 EP - 116 PB - Science Publishing Group SN - 2469-8210 UR - https://doi.org/10.11648/j.jdmp.20160206.16 AB - This study was conducted to clarify the potential role of AGE against damages induced in rats due to exposure to gamma radiation. Adult male albino rats (214-230g). Eight groups, five healthy male rats each were used (20 irradiated and 20 Sham Irradiated), among which some were receiving via gavages distilled water, the others AGE at different doses (25 mg/kg and 50 mg/kg) and the rest vitamin E+Alpha Lipoïc Acid. Blood samples were collected at day 8 post irradiation for biochemical assay. Exposure of rats to gamma radiation caused a significant increase in the level of total cholesterol (TC), triglycerides (TG), LDL-Cholesterol, Malondialdehyde (MDA), Nitrite (NO2-), Creatinine and AST, ALT, ALP and Bilirubin (Total Serum Bilirubin, Direct Bilirubin and Unconjugated Bilirubin)while a significant decrease was recorded in HDL-Cholesterol, serum total proteins, glutathione content (GSH), superoxide dismutase (SOD), catalase (CAT) activities and total protein level in organs tissues. In rats treated with AGE then exposed to radiation, the results showed an improvement in all previous parameters. It could be concluded that AGE might reduce the biological hazards in rats induced by gamma irradiation. VL - 2 IS - 6 ER -
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