Based on an ethnobotanical survey related to inflammatory diseases, 67Guinean plant species belonging to 35 botanical families were inventoried. Some plant species frequently used in the treatment of rheumatism, skin diseases and microbial infections were selected and submitted to a biological investigation including antimicrobial and anticomplement activities. At a concentration of 1mg/ml, all the tested extracts were devoid of any activity against the tested fungi viz Candida albicans, Aspergillus niger, and Trichophyton rubrum and showed a cytotoxicity varying from 0.25 to 500 µg/ml which prevented the evaluation of possible antiviral effects against herpes simplexvirus type 1, Coxsackie-B2, Measle Edmondston A, Poliomyelitis virus type 1, Semliki forest L10 and Vesicular stomatitis virus for viruses. At 1mg/ml, only the extracts ofAgeratum conyzoides, Alchornea cordifolia, Acanthospermum hispidum, Erythrina senegalensis, Harungana madagascariensis, Hymenocardia acida, and Lophira alata showed an antibacterial effect against Bacillus cereus and/or Staphylococcus aureus. All the tested extracts exhibited an inhibitory effect on the Alternative Complement Pathway complement except for Bambusa vulgaris. Only the extracts of Ageratum conyzoides and Hymenocardia acida interfered with both activation pathways of the complement system. The results of the present work support the anti-inflammatory traditional use of some selected plant species which could be explained, at least partly, by their anticomplement properties.
| Published in |
Journal of Plant Sciences (Volume 3, Issue 1-2)
This article belongs to the Special Issue Ethnopharmacological Investigation of Medicinal Plants |
| DOI | 10.11648/j.jps.s.2015030102.13 |
| Page(s) | 11-19 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2014. Published by Science Publishing Group |
Guinea, Ethnobotanical Survey, Anti-Inflammatory, Antimicrobial, Anticomplement
| [1] | Praveen K. D. and Suchita M. (2013): Anti-inflammatory agents of herbal origin: An overview. Int. J. Res. Pharm. Sci., 4 (2), 295-302 |
| [2] | Ill-Min Chung, Eun-Hye Kim, Jong-Jin Kim2 and Hyung-In Moon (2010) : Inhibition effects of the classical pathway complement of isolated compounds from Quercus glauca. Human and Experimental Toxicology ; 30(9) 1415–1419. |
| [3] | Deepa M. and Renuka D. (2014): Potential anti-inflammatory medicinal plants – A Review. Int J Pharm Pharm Sci, 6 (4), 43-49 |
| [4] | Labadie RP, van der Nat JM, Simons JM, Kroes BH, Kosasi S, van den Berg AJ, t' Hart LA, van der Sluis WG, Abeysekera A, Bamunuarachchi A, et al.(1989): An ethnopharmacognostic approach to the search for immunomodulators of plant origin. Planta Med.55(4):339-48. |
| [5] | Cimanga K, De Bruyne T, lasure A, Van Poel B, Pieters L, Vanden Bergh D, Vlietinck A. (1995) : In vitro anticomplement activity of constituents from Morinda morindoides. J. Nat. Prod., 58 (3) , P372 - 378 |
| [6] | Fraser D.A., Harris C.L., Smith R.A.G, and Morgan B.P. (2002): Bacterial expression and membrane targeting of the rat complement regulator Crry: A new model anticomplement therapeutic. Protein Sci ; 11; 2512-2521. |
| [7] | Vanden Bergh, D.A., Vlietinck, A.J. (1991): in: Dey, P.M., Harborne, J.B. (Eds), Methods in Plant Biochemistry: Screening Methods for Antibacterial and Antiviral Agents from Higher Plants. Academic Press, London, 47-69. |
| [8] | Mayer M.M. (1971): in “Experimental immunochemistry”. Ed. By Kabat E. and Mayer.M, 2nd Ed., Charles C. Thomas, Springfield, II., Ch. 4, pp. 133-240 |
| [9] | Platts-Mills T.A.E. and Ishizaka K. (1974) : J. Immunpl., 113, 348 |
| [10] | Basilevskaia,V.(1969): Plantes Medicicnales de Guinée. République de Guinée, 127,184. |
| [11] | Kouakou K, Schepetkin I.A., Yapi A., Kirpotina L.N., Jutila M.A., Quinn M.T.(2013) :Immunomodulatory activity of polysaccahrides isolated from Alchornea cordifolia J Ethnopharmacol 146, 232-242 |
| [12] | Basilevskaia,V.(1969): Plantes Medicicnales de Guinée. République de Guinée ,127,184. |
| [13] | Kamboj A, Saluja AK. (2008): Ageratum conyzoides L: a review on its phytochemical and pharmacological profile. Int J Green Pharm; 2: 59-68 |
| [14] | Oladejo OW, Imosemi IO, Osuagwu FC, Oyedele OO, Oluwadara OO, Ekpo OE, et al. (2003): A comparative study of the wound healing properties of honey and Ageratum conyzoides. Afr J Med Sci; 32(2): 193-6. |
| [15] | Sravanprasad M., Manoranjan S., Sharadanalla, Venkateshwarlu.G, Rajeshwari E. (2012): Evaluation of anti-Microbial activity of Bambusa vulgaris leaves. International Journal of Phytothearpy Research, 2 (2) ; 36-39 |
| [16] | Carey WM, Dasi JM, Rao NV, Gottumukkala KM.(2009): Anti-inflammatory activity of methanolic extract of Bambusa vulgaris leaves. Int J Green Pharm;3:234-8 |
| [17] | Ibewuike J.C., Ogungbamila,F.O., Ogundaini A.O., Okeke I.N., and Bohlin L.(1997) :Antiinflammatory and Antibacterial Activities of C-methylflavonols from Piliostigma thonningii. Phytother. Res. 11, 281–284. |
| [18] | Le Grand, A., Wondergem, P.A., Verpoorte, R. and Pousset, J.L.(1988): Anti-infectious Phytotherapies of the Tree-Savannah of Senegal (West-Africa) II. Antimicrobial Activity of 33 Species. J. Ethnopharmacol., 22, 25-31. |
| [19] | Vlietinck A.J., Van Hoof L., Totte J., Lasure A., Berghe D., Rwangbo P.C., Mvukiyumwani J. (1995): Screening of hundred Rwandese medicinal plants for antimalarial properties. J. Ethnopharmacol. 46, 31-47 |
| [20] | Nwodo, O.F.C. (1989): Antibiotic and anti-inflammatory analgesic activities of Harungana madagascariensis stem bark. Int. J. Crude Drug Res., 27, 3, 137-140. |
| [21] | Muanza, D.N., Kim, B.W., Euler, K.L. and Williams, L. (1994): Antibacterial and antifungal activities of nine plants from Zaire. Int. J. Pharmacog., 32, 4, 337-345. |
| [22] | Madubunyi, I.I., Obi, S.K.C., Nwebube, N.I. and Chime, A.B. (1995): Antihepatotoxic and antimicrobial activities of Harungana madagascariensis leaf extracts. International Journal of Pharmacology, 33, 2, 129-134. |
| [23] | Tih, A., Martin, M., Tih, R. G., Vuidepot, I., Sondengam, B. and Bodo, B. (1992): Lophiroflvans B and C, tetraflavanoids of Lophira alata. Phytochemistry, 31, 10, 3595-3599. |
| [24] | Ajao, A.O. , Shonuka, O. and Femi-Onadeko, B. (1985): Antibacterial effect of aqueous and alcohol extracts of Spondia monbin and Alchornea cordifolia – Two local antimicrobial remedies. Int. J. Crude Drug Res. 23, 2, 67-72 |
| [25] | Maïkere-Faniyo,R., Van Puyvelde, L., Mutwewingabo, A. and Habiyaremye, F.X. (1989): Study of Rwandese medicinal Plants Used in the Treatment of Diarrhoea. Journal of Ethnopharmacology, 26, 101-109. |
| [26] | Malcolm, S.A. and Sofowora, E.A. (1969): Antimicrobial activity of selected nigerian folk remedies and their constituent plants. Lloydia, 32, 4, 512-517. |
| [27] | Antia BS, Okokon JE, Etim EI, Umoh UF, Bassey EO.(2009): Evaluation of the in vivo antimalarial activity of ethanolic leaf and stembark extracts of Anthocleista djalonensis. Indian J Pharmacol; 41(6): 258-261. |
| [28] | Chah KF, Eze CA, Emuelosi CE, Esimone CO.(2006): Antibacterial and wound healing properties of methanolic extracts of some Nigerian medicinal plants. J Ethnopharmacol; 104: 164-167. |
| [29] | Nweze NE, Ngongeh LA.(2007): In vitro anthelmintic activity of Anthocleista djalonensis. Nigerian Vet J; 28(1): 9-13. |
| [30] | Ajali U. (2000) : Antibacterial activity of Alchornea cordifolia stem bark. Fitoterapia 71 ; 436-438 |
| [31] | Mario E. Arena, Elena Cartagena, Nadia Gobbato, Mario Baigori, Juan C. Valdez and Alicia Bardon (2011) : In Vivo and In Vitro Antibacterial Activity of Acanthospermal B, a Sesquiterpene Lactone Isolated from Acanthospermum hispidum. Phytother. Res. 25: 597–602 |
| [32] | Lasure, A., Van Poel, B., Pieters, L., Claeys, M., Gupta, M., Vanden Berghe, D. and Vietinck, A.J. (1994) : Complement inhibiting properties of Apeiba tibourbou. Planta Medica, 60, 276-277. |
| [33] | Makambila-Koubemba MC., Mbatchi B., ArdidD., Gelot A., Henrion C., Janisson R., Abena AA., Banzouzi JT. (2011) : Pharmacological studies of ten medicinal plants used for analgesic purposes in Congo Brazzaville. Int J. of Pharmacology; 7 (5) 608-615 |
| [34] | Saidu K., Onah J., Orisadipe A., Olusola A., Wambebe C., Gamaniel K. (2000): Antiplasmodial, analgesic, and anti-inflammatory activities of the aqueous extract of the stem bark of Erythrina senegalensis. Journal of Ethnopharmacology. 71; 275–280. |
| [35] | Ezekiel. Olugbenga Iwalewa, Isaac O Adewale, Bamigboye J Taiwo, Tope Arogundade, Ade Osinowo, Oluwatoyin M Daniyan, Gbade E Adetogun (2008) : Effects of Harungana madagascariensis Stem Bark Extract on the Antioxidant Markers in Alloxan Induced Diabetic and Carrageenan Induced Inflammatory Disorders in Rats. Journal of Complementary and Integrative Medicine. Volume 5, Issue 1, ISSN (Online) 1553-3840, DOI: 10.2202/1553-3840.1088, February 2008 |
| [36] | Annan K. and Dickson R. (2008): Evaluation of wound healing actions of Hoslundia opposita Vahl, Anthocleista nobilis G. Don and Balanites aegyptiaca L. Journal of Science and Technology 28 (2): 26-35. |
| [37] | .Uche, F I., Aprioku, J.S. (2008): The Phytochemical Constituents, Analgesic and Anti-inflammatory effects of methanol extract of Jatropha curcas leaves in Mice and Wister albino rats. J. Appl. Sci. Environ. Manage. 12(4) ; 99 - 102 |
| [38] | Mujumdar AM, Misar AV. (2004): Anti-inflammatory activity of Jatropha curcas roots in mice and rats. J Ethnopharmacol.; 90(1) : 11-5. |
| [39] | Mavar-Manga H, Brkic D, Marie DEP, Quetin-Leclercq J (2004) : In vivo anti-inflammatory activity of Alchornea cordifolia (Schumach & Thonn.) Müll.(Euphorbiaceae). Journal of Ethnopharmacology, 92, 209-214. |
| [40] | Osadebe, P.O., Okoye, F.B.C., (2003):. Anti-inflammatory effects of crude methanolic extract and fractions of Alchornea cordifolia leaves. Journal of Ethnopharmacology 89, 19–24. |
| [41] | Labadie, R.P. (1993): Immunomodulatory compounds. In Bioactive Natural Products. Colegate, S.M. and Molyneux, R.J., CRC Press, 280-317 |
| [42] | Wagner, H. and Jurcic, K. (1991): Assays for immunomodulation and effects on mediators of inflammatiom, In Methods in Plant Biochemistry, Vol.6, 195-217, Dey, P.M. and Harborne, J.B. series eds, Academic press, London |
| [43] | Mavar-Manga H, Haddad M, Pieters L, Baccelli C, Penge A, Quetin-Leclercq J (2008): Anti-inflammatory compounds from leaves and root-bark of Alchornea cordifolia (Schumach & Thonn.) Müll. Arg. Journal of Ethnopharmacology, 115, 25-29. |
| [44] | Murakami A., Tanaka S., Ohigashi H., Hirota M, Irie R, Takeda N, Tatematsu A & Koshimizu K. (1992) : Chalcone Tetramers, Lophirachalcone and Alatachalcone, from Lophira alata as Possible Anti-tumor Promoters. Bioscience, Biotechnology, and Biochemistry. 56, 5, 769 – 772 |
APA Style
A. M. Baldé, M. S. Traoré, M. S. T. Diallo, E. S. Baldé, Y. Huang, et al. (2014). Ethnobotanical Survey, Antimicrobial and Anticomplement Activities of Guinean Medicinal Plants Traditionally Used in the Treatment of Inflammatory Diseases in Conakry and Dubreka. Journal of Plant Sciences, 3(1-2), 11-19. https://doi.org/10.11648/j.jps.s.2015030102.13
ACS Style
A. M. Baldé; M. S. Traoré; M. S. T. Diallo; E. S. Baldé; Y. Huang, et al. Ethnobotanical Survey, Antimicrobial and Anticomplement Activities of Guinean Medicinal Plants Traditionally Used in the Treatment of Inflammatory Diseases in Conakry and Dubreka. J. Plant Sci. 2014, 3(1-2), 11-19. doi: 10.11648/j.jps.s.2015030102.13
AMA Style
A. M. Baldé, M. S. Traoré, M. S. T. Diallo, E. S. Baldé, Y. Huang, et al. Ethnobotanical Survey, Antimicrobial and Anticomplement Activities of Guinean Medicinal Plants Traditionally Used in the Treatment of Inflammatory Diseases in Conakry and Dubreka. J Plant Sci. 2014;3(1-2):11-19. doi: 10.11648/j.jps.s.2015030102.13
Share This Article
Twitter
Linked In
Facebook
Copy
Download@article{10.11648/j.jps.s.2015030102.13,
author = {A. M. Baldé and M. S. Traoré and M. S. T. Diallo and E. S. Baldé and Y. Huang and Z. Liu and K. Oularé and M. S. Barry and M. A. Baldé and A. Camara and D. Vanden Berghe and A. Vlietinck and L. Pieters},
title = {Ethnobotanical Survey, Antimicrobial and Anticomplement Activities of Guinean Medicinal Plants Traditionally Used in the Treatment of Inflammatory Diseases in Conakry and Dubreka},
journal = {Journal of Plant Sciences},
volume = {3},
number = {1-2},
pages = {11-19},
doi = {10.11648/j.jps.s.2015030102.13},
url = {https://doi.org/10.11648/j.jps.s.2015030102.13},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jps.s.2015030102.13},
abstract = {Based on an ethnobotanical survey related to inflammatory diseases, 67Guinean plant species belonging to 35 botanical families were inventoried. Some plant species frequently used in the treatment of rheumatism, skin diseases and microbial infections were selected and submitted to a biological investigation including antimicrobial and anticomplement activities. At a concentration of 1mg/ml, all the tested extracts were devoid of any activity against the tested fungi viz Candida albicans, Aspergillus niger, and Trichophyton rubrum and showed a cytotoxicity varying from 0.25 to 500 µg/ml which prevented the evaluation of possible antiviral effects against herpes simplexvirus type 1, Coxsackie-B2, Measle Edmondston A, Poliomyelitis virus type 1, Semliki forest L10 and Vesicular stomatitis virus for viruses. At 1mg/ml, only the extracts ofAgeratum conyzoides, Alchornea cordifolia, Acanthospermum hispidum, Erythrina senegalensis, Harungana madagascariensis, Hymenocardia acida, and Lophira alata showed an antibacterial effect against Bacillus cereus and/or Staphylococcus aureus. All the tested extracts exhibited an inhibitory effect on the Alternative Complement Pathway complement except for Bambusa vulgaris. Only the extracts of Ageratum conyzoides and Hymenocardia acida interfered with both activation pathways of the complement system. The results of the present work support the anti-inflammatory traditional use of some selected plant species which could be explained, at least partly, by their anticomplement properties.},
year = {2014}
}
TY - JOUR T1 - Ethnobotanical Survey, Antimicrobial and Anticomplement Activities of Guinean Medicinal Plants Traditionally Used in the Treatment of Inflammatory Diseases in Conakry and Dubreka AU - A. M. Baldé AU - M. S. Traoré AU - M. S. T. Diallo AU - E. S. Baldé AU - Y. Huang AU - Z. Liu AU - K. Oularé AU - M. S. Barry AU - M. A. Baldé AU - A. Camara AU - D. Vanden Berghe AU - A. Vlietinck AU - L. Pieters Y1 - 2014/12/27 PY - 2014 N1 - https://doi.org/10.11648/j.jps.s.2015030102.13 DO - 10.11648/j.jps.s.2015030102.13 T2 - Journal of Plant Sciences JF - Journal of Plant Sciences JO - Journal of Plant Sciences SP - 11 EP - 19 PB - Science Publishing Group SN - 2331-0731 UR - https://doi.org/10.11648/j.jps.s.2015030102.13 AB - Based on an ethnobotanical survey related to inflammatory diseases, 67Guinean plant species belonging to 35 botanical families were inventoried. Some plant species frequently used in the treatment of rheumatism, skin diseases and microbial infections were selected and submitted to a biological investigation including antimicrobial and anticomplement activities. At a concentration of 1mg/ml, all the tested extracts were devoid of any activity against the tested fungi viz Candida albicans, Aspergillus niger, and Trichophyton rubrum and showed a cytotoxicity varying from 0.25 to 500 µg/ml which prevented the evaluation of possible antiviral effects against herpes simplexvirus type 1, Coxsackie-B2, Measle Edmondston A, Poliomyelitis virus type 1, Semliki forest L10 and Vesicular stomatitis virus for viruses. At 1mg/ml, only the extracts ofAgeratum conyzoides, Alchornea cordifolia, Acanthospermum hispidum, Erythrina senegalensis, Harungana madagascariensis, Hymenocardia acida, and Lophira alata showed an antibacterial effect against Bacillus cereus and/or Staphylococcus aureus. All the tested extracts exhibited an inhibitory effect on the Alternative Complement Pathway complement except for Bambusa vulgaris. Only the extracts of Ageratum conyzoides and Hymenocardia acida interfered with both activation pathways of the complement system. The results of the present work support the anti-inflammatory traditional use of some selected plant species which could be explained, at least partly, by their anticomplement properties. VL - 3 IS - 1-2 ER -
Email: