The Systematic Use of Fibrin-Based Biological Adhesive to Prevent Leakage Due to Healing Defects in Rectal Anastomosis Significantly Reduces Costs

Jesús Lago Oliver; Salvador Argudo Garijo; Mauricio Burneo Estéves; Marta Cuadrado Ayuso; Fernando Turégano Fuentes; Araceli Casado Gómez

doi:doi:10.11648/j.js.20150302.12

The Systematic Use of Fibrin-Based Biological Adhesive to Prevent Leakage Due to Healing Defects in Rectal Anastomosis Significantly Reduces Costs

Jesús Lago Oliver, Salvador Argudo Garijo, Mauricio Burneo Estéves, Marta Cuadrado Ayuso, Fernando Turégano Fuentes, Araceli Casado Gómez

Published in Journal of Surgery (Volume 3, Issue 2)

Received: 30 March 2015 Accepted: 14 April 2015 Published: 30 April 2015

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Abstract

Objective: To analyse hospital costs in the pre-, and intra- and post-operative periods associated with patients undergoing rectal resection with anastomosis, comparing the costs per patient with and without the use of fibrin-based biological adhesive(Tissucol Duo®). Methods: The cost analysis was designed with a subsample of 37 patients who underwent rectal anastomosis in a randomised, single-blind, controlled, parallel comparison between two groups, to evaluate the effectiveness of fibrin-based biological adhesive used to prevent anastomotic leakage. The total costs included diagnostic tests, laboratory tests, hospital stay, adhesive cost, surgery, reintervention and drug treatment. Results: The patients had a mean age of 64.33 years, with a higher proportion of men (62.2%). The study groups were homogeneous and comparable. The average total cost in the group with biological adhesive was€ 10,304.84 compared to € 17,845.12 in the group without biological adhesive. Significant differences were found in the average cost of reintervention between groups: € 119.76 with adhesive vs. € 639.20 for the control group. Conclusions: The total cost decreased by 42% in the group in which a biological adhesive was applied compared to the group in which the adhesive was not applied. This percentage represented a difference of € 7,540.28 in the total average cost per patient.

Published in	Journal of Surgery (Volume 3, Issue 2)
DOI	10.11648/j.js.20150302.12
Page(s)	12-17
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2015. Published by Science Publishing Group

Keywords

Cost Analysis, Rectal Anastomoses, Fibrin-Based Biological Adhesive

References

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[6]	Avalos-González J, Portilla-de Buen E, Leal-Cortés CA, et al. “Reduction of the closure time of postoperative enterocutaneous fistulas with fibrin sealant”. World J Gastroenterol 2010;16:2793–2800.
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[14]	Dhua AK, Ratan SK, Aggarwal SK. “Chylothorax after Primary Repair of Esophageal Atresia with Tracheo-esophageal Fistula: Successful Management by Biological Fibrin Glue”. APSP J Case Rep 2012;3:16.
[15]	Ramón Rábago L, Moral I, Delgado M, et al. “Tratamiento endoscópico de fístulas gastrointestinales con un pegamento biológico tisular”. [Endoscopic treatment of gastrointestinal fistulas with biological tissue glue.] Gastroenterol Hepatol 2006;29:390-396.
[16]	TissucolDuo®. Summary of Products Characteristics. Available at: http://www.aemps.gob.es/cima/pdfs/es/ft/60427/FT_60427.pdf
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APA Style

Jesús Lago Oliver, Salvador Argudo Garijo, Mauricio Burneo Estéves, Marta Cuadrado Ayuso, Fernando Turégano Fuentes, et al. (2015). The Systematic Use of Fibrin-Based Biological Adhesive to Prevent Leakage Due to Healing Defects in Rectal Anastomosis Significantly Reduces Costs. Journal of Surgery, 3(2), 12-17. https://doi.org/10.11648/j.js.20150302.12

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ACS Style

Jesús Lago Oliver; Salvador Argudo Garijo; Mauricio Burneo Estéves; Marta Cuadrado Ayuso; Fernando Turégano Fuentes, et al. The Systematic Use of Fibrin-Based Biological Adhesive to Prevent Leakage Due to Healing Defects in Rectal Anastomosis Significantly Reduces Costs. J. Surg. 2015, 3(2), 12-17. doi: 10.11648/j.js.20150302.12

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AMA Style

Jesús Lago Oliver, Salvador Argudo Garijo, Mauricio Burneo Estéves, Marta Cuadrado Ayuso, Fernando Turégano Fuentes, et al. The Systematic Use of Fibrin-Based Biological Adhesive to Prevent Leakage Due to Healing Defects in Rectal Anastomosis Significantly Reduces Costs. J Surg. 2015;3(2):12-17. doi: 10.11648/j.js.20150302.12

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@article{10.11648/j.js.20150302.12,
  author = {Jesús Lago Oliver and Salvador Argudo Garijo and Mauricio Burneo Estéves and Marta Cuadrado Ayuso and Fernando Turégano Fuentes and Araceli Casado Gómez},
  title = {The Systematic Use of Fibrin-Based Biological Adhesive to Prevent Leakage Due to Healing Defects in Rectal Anastomosis Significantly Reduces Costs},
  journal = {Journal of Surgery},
  volume = {3},
  number = {2},
  pages = {12-17},
  doi = {10.11648/j.js.20150302.12},
  url = {https://doi.org/10.11648/j.js.20150302.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.js.20150302.12},
  abstract = {Objective: To analyse hospital costs in the pre-, and intra- and post-operative periods associated with patients undergoing rectal resection with anastomosis, comparing the costs per patient with and without the use of fibrin-based biological adhesive(Tissucol Duo®). Methods: The cost analysis was designed with a subsample of 37 patients who underwent rectal anastomosis in a randomised, single-blind, controlled, parallel comparison between two groups, to evaluate the effectiveness of fibrin-based biological adhesive used to prevent anastomotic leakage. The total costs included diagnostic tests, laboratory tests, hospital stay, adhesive cost, surgery, reintervention and drug treatment. Results: The patients had a mean age of 64.33 years, with a higher proportion of men (62.2%). The study groups were homogeneous and comparable. The average total cost in the group with biological adhesive was€ 10,304.84 compared to € 17,845.12 in the group without biological adhesive. Significant differences were found in the average cost of reintervention between groups: € 119.76 with adhesive vs. € 639.20 for the control group. Conclusions: The total cost decreased by 42% in the group in which a biological adhesive was applied compared to the group in which the adhesive was not applied. This percentage represented a difference of € 7,540.28 in the total average cost per patient.},
 year = {2015}
}

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TY  - JOUR
T1  - The Systematic Use of Fibrin-Based Biological Adhesive to Prevent Leakage Due to Healing Defects in Rectal Anastomosis Significantly Reduces Costs
AU  - Jesús Lago Oliver
AU  - Salvador Argudo Garijo
AU  - Mauricio Burneo Estéves
AU  - Marta Cuadrado Ayuso
AU  - Fernando Turégano Fuentes
AU  - Araceli Casado Gómez
Y1  - 2015/04/30
PY  - 2015
N1  - https://doi.org/10.11648/j.js.20150302.12
DO  - 10.11648/j.js.20150302.12
T2  - Journal of Surgery
JF  - Journal of Surgery
JO  - Journal of Surgery
SP  - 12
EP  - 17
PB  - Science Publishing Group
SN  - 2330-0930
UR  - https://doi.org/10.11648/j.js.20150302.12
AB  - Objective: To analyse hospital costs in the pre-, and intra- and post-operative periods associated with patients undergoing rectal resection with anastomosis, comparing the costs per patient with and without the use of fibrin-based biological adhesive(Tissucol Duo®). Methods: The cost analysis was designed with a subsample of 37 patients who underwent rectal anastomosis in a randomised, single-blind, controlled, parallel comparison between two groups, to evaluate the effectiveness of fibrin-based biological adhesive used to prevent anastomotic leakage. The total costs included diagnostic tests, laboratory tests, hospital stay, adhesive cost, surgery, reintervention and drug treatment. Results: The patients had a mean age of 64.33 years, with a higher proportion of men (62.2%). The study groups were homogeneous and comparable. The average total cost in the group with biological adhesive was€ 10,304.84 compared to € 17,845.12 in the group without biological adhesive. Significant differences were found in the average cost of reintervention between groups: € 119.76 with adhesive vs. € 639.20 for the control group. Conclusions: The total cost decreased by 42% in the group in which a biological adhesive was applied compared to the group in which the adhesive was not applied. This percentage represented a difference of € 7,540.28 in the total average cost per patient.
VL  - 3
IS  - 2
ER  -

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Author Information

Jesús Lago Oliver

Surgery Department, University Hospital Gregorio Mara?ón, Madrid, Spain
Salvador Argudo Garijo

Surgery Department, Southeast University Hospital.Arganda del Rey, Madrid, Spain
Mauricio Burneo Estéves

Surgery Department, University Hospital Gregorio Mara?ón, Madrid, Spain
Marta Cuadrado Ayuso

Surgery Department, University Hospital Gregorio Mara?ón, Madrid, Spain
Fernando Turégano Fuentes

Surgery Department, University Hospital Gregorio Mara?ón, Madrid, Spain
Araceli Casado Gómez

Pharmacoeconomics & Outcomes Research Iberia, Madrid, Spain

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APA Style

Jesús Lago Oliver, Salvador Argudo Garijo, Mauricio Burneo Estéves, Marta Cuadrado Ayuso, Fernando Turégano Fuentes, et al. (2015). The Systematic Use of Fibrin-Based Biological Adhesive to Prevent Leakage Due to Healing Defects in Rectal Anastomosis Significantly Reduces Costs. Journal of Surgery, 3(2), 12-17. https://doi.org/10.11648/j.js.20150302.12

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ACS Style

Jesús Lago Oliver; Salvador Argudo Garijo; Mauricio Burneo Estéves; Marta Cuadrado Ayuso; Fernando Turégano Fuentes, et al. The Systematic Use of Fibrin-Based Biological Adhesive to Prevent Leakage Due to Healing Defects in Rectal Anastomosis Significantly Reduces Costs. J. Surg. 2015, 3(2), 12-17. doi: 10.11648/j.js.20150302.12

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AMA Style

Jesús Lago Oliver, Salvador Argudo Garijo, Mauricio Burneo Estéves, Marta Cuadrado Ayuso, Fernando Turégano Fuentes, et al. The Systematic Use of Fibrin-Based Biological Adhesive to Prevent Leakage Due to Healing Defects in Rectal Anastomosis Significantly Reduces Costs. J Surg. 2015;3(2):12-17. doi: 10.11648/j.js.20150302.12

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@article{10.11648/j.js.20150302.12,
  author = {Jesús Lago Oliver and Salvador Argudo Garijo and Mauricio Burneo Estéves and Marta Cuadrado Ayuso and Fernando Turégano Fuentes and Araceli Casado Gómez},
  title = {The Systematic Use of Fibrin-Based Biological Adhesive to Prevent Leakage Due to Healing Defects in Rectal Anastomosis Significantly Reduces Costs},
  journal = {Journal of Surgery},
  volume = {3},
  number = {2},
  pages = {12-17},
  doi = {10.11648/j.js.20150302.12},
  url = {https://doi.org/10.11648/j.js.20150302.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.js.20150302.12},
  abstract = {Objective: To analyse hospital costs in the pre-, and intra- and post-operative periods associated with patients undergoing rectal resection with anastomosis, comparing the costs per patient with and without the use of fibrin-based biological adhesive(Tissucol Duo®). Methods: The cost analysis was designed with a subsample of 37 patients who underwent rectal anastomosis in a randomised, single-blind, controlled, parallel comparison between two groups, to evaluate the effectiveness of fibrin-based biological adhesive used to prevent anastomotic leakage. The total costs included diagnostic tests, laboratory tests, hospital stay, adhesive cost, surgery, reintervention and drug treatment. Results: The patients had a mean age of 64.33 years, with a higher proportion of men (62.2%). The study groups were homogeneous and comparable. The average total cost in the group with biological adhesive was€ 10,304.84 compared to € 17,845.12 in the group without biological adhesive. Significant differences were found in the average cost of reintervention between groups: € 119.76 with adhesive vs. € 639.20 for the control group. Conclusions: The total cost decreased by 42% in the group in which a biological adhesive was applied compared to the group in which the adhesive was not applied. This percentage represented a difference of € 7,540.28 in the total average cost per patient.},
 year = {2015}
}

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TY  - JOUR
T1  - The Systematic Use of Fibrin-Based Biological Adhesive to Prevent Leakage Due to Healing Defects in Rectal Anastomosis Significantly Reduces Costs
AU  - Jesús Lago Oliver
AU  - Salvador Argudo Garijo
AU  - Mauricio Burneo Estéves
AU  - Marta Cuadrado Ayuso
AU  - Fernando Turégano Fuentes
AU  - Araceli Casado Gómez
Y1  - 2015/04/30
PY  - 2015
N1  - https://doi.org/10.11648/j.js.20150302.12
DO  - 10.11648/j.js.20150302.12
T2  - Journal of Surgery
JF  - Journal of Surgery
JO  - Journal of Surgery
SP  - 12
EP  - 17
PB  - Science Publishing Group
SN  - 2330-0930
UR  - https://doi.org/10.11648/j.js.20150302.12
AB  - Objective: To analyse hospital costs in the pre-, and intra- and post-operative periods associated with patients undergoing rectal resection with anastomosis, comparing the costs per patient with and without the use of fibrin-based biological adhesive(Tissucol Duo®). Methods: The cost analysis was designed with a subsample of 37 patients who underwent rectal anastomosis in a randomised, single-blind, controlled, parallel comparison between two groups, to evaluate the effectiveness of fibrin-based biological adhesive used to prevent anastomotic leakage. The total costs included diagnostic tests, laboratory tests, hospital stay, adhesive cost, surgery, reintervention and drug treatment. Results: The patients had a mean age of 64.33 years, with a higher proportion of men (62.2%). The study groups were homogeneous and comparable. The average total cost in the group with biological adhesive was€ 10,304.84 compared to € 17,845.12 in the group without biological adhesive. Significant differences were found in the average cost of reintervention between groups: € 119.76 with adhesive vs. € 639.20 for the control group. Conclusions: The total cost decreased by 42% in the group in which a biological adhesive was applied compared to the group in which the adhesive was not applied. This percentage represented a difference of € 7,540.28 in the total average cost per patient.
VL  - 3
IS  - 2
ER  -

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