The aim of this study is to reveal the etiologic link that exists between pancreatic cancer and chronic pancreatitis through our unicentric experience. The clinical and cyto-pathological results of 300 patients were studied prospectively from January to December 2014 in the pancreatic center of Wuhan union hospital in china. Of the 300 pancreatic lesions patients, 196 were male and 104 female with a sex ratio of 1.8:1 (p=0.001). The factors assessed for the determination of etiologic link were the age, gender, the diameter of the lesion, the antecedents of disease (such as ulcer,cholecystectomy, smoking ,alcohol abuse ),the pancreatic lesion site, the diabetic link, the clinical presentations, the level of transaminases (GGT, ALP), peripheral blood analysis and cytopathological results of both PC and CP groups . According to the clinical data along with the respective results of the examinations, causal factors that link CP and PC are illustrated and it opens the pathway for further detailed studies as an investment for the future.
Published in | Journal of Surgery (Volume 3, Issue 6) |
DOI | 10.11648/j.js.20150306.12 |
Page(s) | 59-65 |
Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
Copyright |
Copyright © The Author(s), 2015. Published by Science Publishing Group |
Pancreatic Cancer, Chronic Pancreatitis, Etiologic Link, Unicentric Experience, Pancreatic Lesions
[1] | Camara, S. N., Ramdany, S., Balde, O. T., Barry, A. B., & Adji, S. (2015). Etiology, pathology, management and prognosis of chronic pancreatitis in Chinese population: A retrospective study. J Huazhong UnivSci Technolog MedSci, 35, 384-389. |
[2] | Jemal, A., Siegel, R., Xu, J., & Ward, E. Cancer statistics. CA cancer JClin 2010, 60, 277-300. |
[3] | Koninger, J., Friess, H., Muller, M., & Buchler, M. W. (2004). Duodenum preserving pancreatic head resection in the treatment of chronic pancreatitis. Rocz Akad Med Bialymst, 49, 53-60. |
[4] | Balkwill, F., & Mantovani A. Inflammation and cancer: back to Virchow? The lancet, 2001, 357, 539-545. |
[5] | Pinho, A. V., Chantrill, L., & Rooman, I. (2014). Chronic pancreatitis: a path to pancreatic cancer. Cancer letters, 345(2), 203-209. |
[6] | Tuveson, D. A., & Neoptolemos, J. P. (2012). Understanding metastasis in pancreatic cancer: a call for new clinical approaches. Cell, 148, 21-23. |
[7] | MitchellP. Fink. Partiallist of physiologic effects induced by infusing interleukin 1 or tumor necrosis factor into human subjects. Sabiston textbook of surgery 19ed page 48. |
[8] | Raimondi, S., Lowenfels, A. B., Morselli-Labate, A. M., Maisonneuve, P., & Pezzilli, R. Pancreatic cancer in chronic pancreatitis; aetiology, incidence, and early detection. Best practice & research Clingastroenterolog, 2010, 24, 349-358. |
[9] | Szasz, G. (1969). A kinetic photometric method for serum γ-glutamyltranspeptidase. Clinchemist, 15, 124-136. |
[10] | Lum, G., & Gambino, S. R. Serum gamma-glutamyltranspeptidase activity as an indicator of disease of liver, pancreas, or bone. Clin Chemist, 1972, 18, 358-362. |
[11] | Beatty, G. L., Chiorean, E. G., Fishman, M. P., Saboury, B., Teitelbaum, U. R., et al. CD40 agonists alter tumor stroma and show efficacy against pancreatic carcinoma in mice and humans. Sci, 2011, 331, 1612-1616. |
[12] | Bedi, M. M. S., Gandhi, M. D., Jacob, G., Lekha, V., Venugopal, A., et al.. CA 19-9 to differentiate benign and malignant masses in chronic pancreatitis: is there any benefit? IJG, 2009, 28, 24-27. |
[13] | Campbell, A. S., Albo, D., Kimsey, T. F., White, S. L., & Wang, T. N. Macrophage inflammatory protein-3α promotes pancreatic cancer cell invasion Surg Res, 2005, 123, 96-101. |
[14] | Mazzieri, R., Pucci, F., Moi, D., Zonari, E., Ranghetti, A., et al. Targeting the ANG2/TIE2 axis inhibits tumor growth and metastasis by impairing angiogenesis and disabling rebounds of proangiogenic myeloid cells. Cancer cell, 2011, 19, 512-526. |
[15] | Mitchem, J. B., Brennan, D. J., Knolhoff, B. L., Belt, B. A., Zhu, Y., et al. (2013). Targeting tumor-infiltrating macrophages decreases tumor-initiating cells, relieves immunosuppression, and improves chemotherapeutic responses. Cancer research, 2013, 73, 1128-1141. |
[16] | Kaiser, M. H., & Ellenberg, S. S. (1985). Pancreatic cancer: adjuvant combined radiation and chemotherapy following curative resection. Arch Surg, 1985, 120, 899-903. |
[17] | Niederau, C., & Grendell, J. H. (1992). Diagnosis of pancreatic carcinoma: imaging techniques and tumor markers. Pancreas, 7(1), 66-86. |
[18] | Yeo, T. P., & Lowenfels, A. B. (2012). Demographics and epidemiology of pancreatic cancer. The CA J, 2012, 18, 477-484. |
[19] | Bosetti, C., Bertuccio, P., Negri, E., La Vecchia, C., Zeegers, M. P., et al. Pancreatic cancer: overview of descriptive epidemiology. MolCarc, 2012, 51(1), 3-13. |
[20] | Lowenfels, A. B., Walker, A. M., Althaus, D. P., Townsend, G., & Domellöf, L. Gallstone growth, size, and risk of gallbladder cancer: an interracial study. Int J Epidemiol 1989, 18, 50-54. |
[21] | Andren-Sandberg, A., Dervenis, C., & Lowenfels, B. Etiologic links between chronic pancreatitis and pancreatic cancer. Scan J G, 1997, 32, 97-103 |
[22] | Albert B. Lowenfels, Patrick. Maisonneuve, Giorgio Cavallini, Rudolf W. Ammann, Paul G.Lankish, Jens R. Andersen, Eugene P.Dimanno, Ake .Andren-sandberg, Lennart Domellof and the international pancreatitis study group; pancreatitis and the risk of pancreatic cancer. The new England journal of Medecine May 20.1993. Volume 328. Number 20. |
[23] | Ardengh, J. C., Lopes, C. V., Campos, A. D., Pereira de Lima, L. F., Venco, F., et al. Endoscopic ultrasound and fine needle aspiration in chronic pancreatitis: differential diagnosis between pseudotumoral masses and pancreatic cancer. JOP, 2007, 8, 413-421. |
[24] | Rickels, M. R., Bellin, M., Toledo, F. G., Robertson, R. P., Andersen, D. K., et al. (2013). Detection, evaluation and treatment of diabetes mellitus in chronic pancreatitis: recommendations from PancreasFest 2012. Pancreatol, 2013 13, 336-342. |
[25] | Zhang, C., Yang, G., Ling, Y., Chen, G., & Zhou, T. (2014). The early diagnosis of pancreatic cancer and diabetes: what’s the relationship? J GastrointestOncol, 2014, 5, 481-488. |
[26] | Falconi, M., Casetti, L., Salvia, R., Sartori, N., Bettini, R., et al. (2000). Pancreatic head mass, how can we treat it? Chronic pancreatitis: surgical treatment. JOP2000, 1, 154-161. |
[27] | Carr-Locke, D. L., & Davies, T. J. Pancreatic juice gamma-glutamyltransferase, alanine transaminase, and alkaline phosphatase in pancreatic disease. Digest Dis Sci, 1980, 25, 374-378. |
[28] | Wilson Denise, D. Manual of Laboratory & Diagnostic Tests. 2008. |
[29] | Lévy, P., Dominguez Munoz, E., Imrie, C., Löhr, M., & Maisonneuve, P. (2014). Epidemiology of chronic pancreatitis: burden of the disease and consequences. United European gastroenterology journal, 2(5), 345-354. |
[30] | Smailyte, G., Jasilionis, D., Vincerzevskiene, I., Krilaviciute, A., Ambrozaitiene, D., Stankuniene, V., & Shkolnikov, V. M. (2015). Educational differences in incidence of cancer in Lithuania, 2001–2009: evidence from census-linked cancer registry data. European Journal of Cancer Prevention, 24(3), 261-266. |
[31] | Siegel, R., Ma, J., Zou, Z., &Jemal, A. (2014). Cancer statistics, 2014. CA: a cancer journal for clinicians, 64 (1), 9-29. |
[32] | Lennon, A. M., Wolfgang, C. L., Canto, M. I., Klein, A. P., Herman, J. M., Goggins, M., &Hruban, R. H. (2014). The early detection of pancreatic cancer: what will it take to diagnose and treat curable pancreatic neoplasia?.Cancer research, 74(13), 3381-3389. |
APA Style
Soriba Naby Camara, Sonam Ramdany, Sadamoudou Traore, Aissatou Taran Diallo, Yin Tao, et al. (2015). Etiologic Link Between Chronic Pancreatitis and Pancreatic Cancer; A Unicentric Experience of Pancreatic Disease Institute of Wuhan Union Hospital of China. Journal of Surgery, 3(6), 59-65. https://doi.org/10.11648/j.js.20150306.12
ACS Style
Soriba Naby Camara; Sonam Ramdany; Sadamoudou Traore; Aissatou Taran Diallo; Yin Tao, et al. Etiologic Link Between Chronic Pancreatitis and Pancreatic Cancer; A Unicentric Experience of Pancreatic Disease Institute of Wuhan Union Hospital of China. J. Surg. 2015, 3(6), 59-65. doi: 10.11648/j.js.20150306.12
AMA Style
Soriba Naby Camara, Sonam Ramdany, Sadamoudou Traore, Aissatou Taran Diallo, Yin Tao, et al. Etiologic Link Between Chronic Pancreatitis and Pancreatic Cancer; A Unicentric Experience of Pancreatic Disease Institute of Wuhan Union Hospital of China. J Surg. 2015;3(6):59-65. doi: 10.11648/j.js.20150306.12
@article{10.11648/j.js.20150306.12, author = {Soriba Naby Camara and Sonam Ramdany and Sadamoudou Traore and Aissatou Taran Diallo and Yin Tao and Yang Min and Qin Qi and Xiang Li and Jing Yuan Chen and Yong Feng Li and Biro Diallo and Ahmed Boubacar Barry and Oumar Taibata Balde and Gang Zhao and Cui Jing and Aboubacar Toure and Ibrahima Sory Souare and Naby Daouda Camara and He-shui Wu and Chunyou Wang}, title = {Etiologic Link Between Chronic Pancreatitis and Pancreatic Cancer; A Unicentric Experience of Pancreatic Disease Institute of Wuhan Union Hospital of China}, journal = {Journal of Surgery}, volume = {3}, number = {6}, pages = {59-65}, doi = {10.11648/j.js.20150306.12}, url = {https://doi.org/10.11648/j.js.20150306.12}, eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.js.20150306.12}, abstract = {The aim of this study is to reveal the etiologic link that exists between pancreatic cancer and chronic pancreatitis through our unicentric experience. The clinical and cyto-pathological results of 300 patients were studied prospectively from January to December 2014 in the pancreatic center of Wuhan union hospital in china. Of the 300 pancreatic lesions patients, 196 were male and 104 female with a sex ratio of 1.8:1 (p=0.001). The factors assessed for the determination of etiologic link were the age, gender, the diameter of the lesion, the antecedents of disease (such as ulcer,cholecystectomy, smoking ,alcohol abuse ),the pancreatic lesion site, the diabetic link, the clinical presentations, the level of transaminases (GGT, ALP), peripheral blood analysis and cytopathological results of both PC and CP groups . According to the clinical data along with the respective results of the examinations, causal factors that link CP and PC are illustrated and it opens the pathway for further detailed studies as an investment for the future.}, year = {2015} }
TY - JOUR T1 - Etiologic Link Between Chronic Pancreatitis and Pancreatic Cancer; A Unicentric Experience of Pancreatic Disease Institute of Wuhan Union Hospital of China AU - Soriba Naby Camara AU - Sonam Ramdany AU - Sadamoudou Traore AU - Aissatou Taran Diallo AU - Yin Tao AU - Yang Min AU - Qin Qi AU - Xiang Li AU - Jing Yuan Chen AU - Yong Feng Li AU - Biro Diallo AU - Ahmed Boubacar Barry AU - Oumar Taibata Balde AU - Gang Zhao AU - Cui Jing AU - Aboubacar Toure AU - Ibrahima Sory Souare AU - Naby Daouda Camara AU - He-shui Wu AU - Chunyou Wang Y1 - 2015/11/17 PY - 2015 N1 - https://doi.org/10.11648/j.js.20150306.12 DO - 10.11648/j.js.20150306.12 T2 - Journal of Surgery JF - Journal of Surgery JO - Journal of Surgery SP - 59 EP - 65 PB - Science Publishing Group SN - 2330-0930 UR - https://doi.org/10.11648/j.js.20150306.12 AB - The aim of this study is to reveal the etiologic link that exists between pancreatic cancer and chronic pancreatitis through our unicentric experience. The clinical and cyto-pathological results of 300 patients were studied prospectively from January to December 2014 in the pancreatic center of Wuhan union hospital in china. Of the 300 pancreatic lesions patients, 196 were male and 104 female with a sex ratio of 1.8:1 (p=0.001). The factors assessed for the determination of etiologic link were the age, gender, the diameter of the lesion, the antecedents of disease (such as ulcer,cholecystectomy, smoking ,alcohol abuse ),the pancreatic lesion site, the diabetic link, the clinical presentations, the level of transaminases (GGT, ALP), peripheral blood analysis and cytopathological results of both PC and CP groups . According to the clinical data along with the respective results of the examinations, causal factors that link CP and PC are illustrated and it opens the pathway for further detailed studies as an investment for the future. VL - 3 IS - 6 ER -