Age - Related Gastric Changes

Aly Saber; Emad K. Bayumi

doi:doi:10.11648/j.js.s.2016040201.15

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Age - Related Gastric Changes

Aly Saber, Emad K. Bayumi

Published in Journal of Surgery (Volume 4, Issue 2-1)

Received: 17 October 2015 Accepted: 18 October 2015 Published: 13 January 2016

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Abstract

Aging is a universal process with progressive loss of function accompanied by decreasing fertility and increasing mortality and disability. There are several mechanisms to underlie the primary aging process and probably contribute to age-related changes in adaptive responses. These mechanisms are oxidative stress, mitochondrial theory, telomeres and cellular senescence, apoptosis and genetic mechanism. There are many physiological changes with aging process including blood pressure, temperature, fever, and composition of body fluids. Age-related changes in bioavailability may be secondary to changes in absorption or gut wall and hepatic metabolism. The stomach lining's capacity to resist damage decreases with age due to alteration of the gastric defense mechanisms and decreased mucosal blood flow. Normal aging is associated with age-related changes in motor function of the various parts of the gastrointestinal tract such as transit time and gastric emptying. The incidence of many gastrointestinal dysfunctions increases with advancing age that is associated with alterations in the structural and functional integrity of the gastrointestinal tract. The structural changes include mucosa, muscular coat and blood flow. The clinical significance of functional and structural gastric changes may all impact upon gastrointestinal adverse effects and how older people tolerate medicines. Understanding how the upper gastrointestinal tract changes with advancing age could allow interventions that lead to more appropriate prescribing for older people, potentially reduce adverse effects, increase compliance with treatment regimens, and may allow older people to take medications that they would not otherwise tolerate.

Published in	Journal of Surgery (Volume 4, Issue 2-1) This article belongs to the Special Issue Gastrointestinal Surgery: Recent Trends
DOI	10.11648/j.js.s.2016040201.15
Page(s)	20-26
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2016. Published by Science Publishing Group

Keywords

Stomach, Changes, Functional, Structural, Aging

References

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APA Style

Aly Saber, Emad K. Bayumi. (2016). Age - Related Gastric Changes. Journal of Surgery, 4(2-1), 20-26. https://doi.org/10.11648/j.js.s.2016040201.15

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ACS Style

Aly Saber; Emad K. Bayumi. Age - Related Gastric Changes. J. Surg. 2016, 4(2-1), 20-26. doi: 10.11648/j.js.s.2016040201.15

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AMA Style

Aly Saber, Emad K. Bayumi. Age - Related Gastric Changes. J Surg. 2016;4(2-1):20-26. doi: 10.11648/j.js.s.2016040201.15

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@article{10.11648/j.js.s.2016040201.15,
  author = {Aly Saber and Emad K. Bayumi},
  title = {Age - Related Gastric Changes},
  journal = {Journal of Surgery},
  volume = {4},
  number = {2-1},
  pages = {20-26},
  doi = {10.11648/j.js.s.2016040201.15},
  url = {https://doi.org/10.11648/j.js.s.2016040201.15},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.js.s.2016040201.15},
  abstract = {Aging is a universal process with progressive loss of function accompanied by decreasing fertility and increasing mortality and disability. There are several mechanisms to underlie the primary aging process and probably contribute to age-related changes in adaptive responses. These mechanisms are oxidative stress, mitochondrial theory, telomeres and cellular senescence, apoptosis and genetic mechanism. There are many physiological changes with aging process including blood pressure, temperature, fever, and composition of body fluids. Age-related changes in bioavailability may be secondary to changes in absorption or gut wall and hepatic metabolism. The stomach lining's capacity to resist damage decreases with age due to alteration of the gastric defense mechanisms and decreased mucosal blood flow. Normal aging is associated with age-related changes in motor function of the various parts of the gastrointestinal tract such as transit time and gastric emptying. The incidence of many gastrointestinal dysfunctions increases with advancing age that is associated with alterations in the structural and functional integrity of the gastrointestinal tract. The structural changes include mucosa, muscular coat and blood flow. The clinical significance of functional and structural gastric changes may all impact upon gastrointestinal adverse effects and how older people tolerate medicines. Understanding how the upper gastrointestinal tract changes with advancing age could allow interventions that lead to more appropriate prescribing for older people, potentially reduce adverse effects, increase compliance with treatment regimens, and may allow older people to take medications that they would not otherwise tolerate.},
 year = {2016}
}

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TY - JOUR
T1 - Age - Related Gastric Changes
AU - Aly Saber
AU - Emad K. Bayumi
Y1 - 2016/01/13
PY - 2016
N1 - https://doi.org/10.11648/j.js.s.2016040201.15
DO - 10.11648/j.js.s.2016040201.15
T2 - Journal of Surgery
JF - Journal of Surgery
JO - Journal of Surgery
SP - 20
EP - 26
PB - Science Publishing Group
SN - 2330-0930
UR - https://doi.org/10.11648/j.js.s.2016040201.15
AB - Aging is a universal process with progressive loss of function accompanied by decreasing fertility and increasing mortality and disability. There are several mechanisms to underlie the primary aging process and probably contribute to age-related changes in adaptive responses. These mechanisms are oxidative stress, mitochondrial theory, telomeres and cellular senescence, apoptosis and genetic mechanism. There are many physiological changes with aging process including blood pressure, temperature, fever, and composition of body fluids. Age-related changes in bioavailability may be secondary to changes in absorption or gut wall and hepatic metabolism. The stomach lining's capacity to resist damage decreases with age due to alteration of the gastric defense mechanisms and decreased mucosal blood flow. Normal aging is associated with age-related changes in motor function of the various parts of the gastrointestinal tract such as transit time and gastric emptying. The incidence of many gastrointestinal dysfunctions increases with advancing age that is associated with alterations in the structural and functional integrity of the gastrointestinal tract. The structural changes include mucosa, muscular coat and blood flow. The clinical significance of functional and structural gastric changes may all impact upon gastrointestinal adverse effects and how older people tolerate medicines. Understanding how the upper gastrointestinal tract changes with advancing age could allow interventions that lead to more appropriate prescribing for older people, potentially reduce adverse effects, increase compliance with treatment regimens, and may allow older people to take medications that they would not otherwise tolerate.
VL - 4
IS - 2-1
ER -

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Author Information

Aly Saber

Department of general Surgery, Port-Fouad General Hospital, Port-Fouad, Port-Said, Egypt
Emad K. Bayumi

General Surgery, Crimean Medical Academy Named after S.I. Georgiesky of Crimea Federal University, Crimea, Russia

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Plain Text BibTeX RIS

APA Style

Aly Saber, Emad K. Bayumi. (2016). Age - Related Gastric Changes. Journal of Surgery, 4(2-1), 20-26. https://doi.org/10.11648/j.js.s.2016040201.15

Copy | Download

ACS Style

Aly Saber; Emad K. Bayumi. Age - Related Gastric Changes. J. Surg. 2016, 4(2-1), 20-26. doi: 10.11648/j.js.s.2016040201.15

Copy | Download

AMA Style

Aly Saber, Emad K. Bayumi. Age - Related Gastric Changes. J Surg. 2016;4(2-1):20-26. doi: 10.11648/j.js.s.2016040201.15

Copy | Download

@article{10.11648/j.js.s.2016040201.15,
  author = {Aly Saber and Emad K. Bayumi},
  title = {Age - Related Gastric Changes},
  journal = {Journal of Surgery},
  volume = {4},
  number = {2-1},
  pages = {20-26},
  doi = {10.11648/j.js.s.2016040201.15},
  url = {https://doi.org/10.11648/j.js.s.2016040201.15},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.js.s.2016040201.15},
  abstract = {Aging is a universal process with progressive loss of function accompanied by decreasing fertility and increasing mortality and disability. There are several mechanisms to underlie the primary aging process and probably contribute to age-related changes in adaptive responses. These mechanisms are oxidative stress, mitochondrial theory, telomeres and cellular senescence, apoptosis and genetic mechanism. There are many physiological changes with aging process including blood pressure, temperature, fever, and composition of body fluids. Age-related changes in bioavailability may be secondary to changes in absorption or gut wall and hepatic metabolism. The stomach lining's capacity to resist damage decreases with age due to alteration of the gastric defense mechanisms and decreased mucosal blood flow. Normal aging is associated with age-related changes in motor function of the various parts of the gastrointestinal tract such as transit time and gastric emptying. The incidence of many gastrointestinal dysfunctions increases with advancing age that is associated with alterations in the structural and functional integrity of the gastrointestinal tract. The structural changes include mucosa, muscular coat and blood flow. The clinical significance of functional and structural gastric changes may all impact upon gastrointestinal adverse effects and how older people tolerate medicines. Understanding how the upper gastrointestinal tract changes with advancing age could allow interventions that lead to more appropriate prescribing for older people, potentially reduce adverse effects, increase compliance with treatment regimens, and may allow older people to take medications that they would not otherwise tolerate.},
 year = {2016}
}

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