Synthesis, Characterization and Antifungal Activity of Manganese (II) Complex with Schiff Base Derived from Acetylacetone and Leucine

Aishatu Salihu Mohammed; Fatima Abubakar; Abigail Ebi Aye

doi:doi:10.11648/j.nano.20170506.15

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Synthesis, Characterization and Antifungal Activity of Manganese (II) Complex with Schiff Base Derived from Acetylacetone and Leucine

Aishatu Salihu Mohammed, Fatima Abubakar, Abigail Ebi Aye

Published in American Journal of Nano Research and Applications (Volume 5, Issue 6)

Received: 20 October 2017 Accepted: 3 November 2017 Published: 22 December 2017

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Abstract

This study was aimed at synthesizing, characterizing and evaluating the antifungal activity of the Schiff base and Mn (II) complex. The reaction of the mixture of ethanol solution of acetylacetone and leucine yielded a Schiff base. The interaction between the Schiff base in hot aqueous methanol mixture and manganese (II) chloride in ethanol gave the manganese (II) Schiff base complex. The complex was characterized by decomposition/melting point temperatures, solubility test, IR spectrophotometry, colour determination, dissociation constant of Schiff base and antifungal activity. The Schiff base obtained has yellow colour, with a melting point of 250°C and percentage yield of 54.67% while the manganese (II) complex obtained had a pink colour with decomposition temperature of 167°C and percentage yield of 76.40%. The Schiff base and the complex was soluble in some solvents but slightly soluble in others. The Infrared spectra of the Schiff base showed a band at a range of 1600cm^-1 - 1622cm^-1 attributed to v (C=N) stretching frequencies establishing it being a Schiff base. Similar bands were observed in the spectra of Manganese (II) Schiff base complex but in lower frequencies indicating that the Schiff base has coordinated to the Mn ion. The antifungal activity of manganese (II) complex showed significant activity on the fungal isolates Candida albican and Sacchromyces cerevisiae. The study concludes that Schiff base synthesized was a weak acid and the Schiff base was not an active drug against the fungal pathogens used but Mn (II) complex was active against the pathogens used.

Published in	American Journal of Nano Research and Applications (Volume 5, Issue 6)
DOI	10.11648/j.nano.20170506.15
Page(s)	110-113
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2017. Published by Science Publishing Group

Keywords

Antifungal, C. albican, Infrared, Manganese (II), Schiff Base, S. cerevisiae

References

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[3]	D Jeffery. The remarkable story of a wonder drug. Journal of Aspirin. 25 (3), 2005, 50-98.
[4]	A Kimberly, C Nicholas, C Nathaniel and L Anderson. Substituent effects on Keto-Enol Equilibria using NMR Spectroscopy. Journal of Chemical Education, 88 (10), 2011, 1444-1445.
[5]	PA Vigato and S Tamburini. Schiff base: a review of its properties. Journal of Co-ordination Chemistry, 2 (1), 2004, 17.
[6]	F Lebon, N Boggeto and M Lebeca. Metal organic commands a new approach for drug discovery: N -1, 2, 3, 6 - trimethoxy benzamide copper (II) complex as an inhibitor of human immunodeficiency virus protease, Biochemical Pharmacology Journal, 63 (10), 2002, 1863-1873.
[7]	OW Salawu, PK Onoja and JF Saleh. Chemical properties of compounds. J. Der Chemical Sinica, 2 (5), 2011, 25.
[8]	SW Hassan, RA Umar and M Lawal. Evaluation of antifungal activity of Ficus sycomorus L. (moraceae). Best Journal 3 (2), 2006, 18-25.
[9]	J Rosenthal, L Combaret and MR Etzel. Metabolic fate of Leucine: A significant sterol precursor in Adipose tissue and Muscle. American Journal of Physiology, 226 (2), 2008, 411-418.
[10]	M Ul-Hassan, ZH Chohan, A Scozzafava and CT Supuran. Schiff bases of aromatic and heterocyclic sulfonamides and their metal complexes. Journal of Enzyme Inhibition and Medicinal Chemistry. 19 (3), 2004, 263-267.

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APA Style

Aishatu Salihu Mohammed, Fatima Abubakar, Abigail Ebi Aye. (2017). Synthesis, Characterization and Antifungal Activity of Manganese (II) Complex with Schiff Base Derived from Acetylacetone and Leucine. American Journal of Nano Research and Applications, 5(6), 110-113. https://doi.org/10.11648/j.nano.20170506.15

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ACS Style

Aishatu Salihu Mohammed; Fatima Abubakar; Abigail Ebi Aye. Synthesis, Characterization and Antifungal Activity of Manganese (II) Complex with Schiff Base Derived from Acetylacetone and Leucine. Am. J. Nano Res. Appl. 2017, 5(6), 110-113. doi: 10.11648/j.nano.20170506.15

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AMA Style

Aishatu Salihu Mohammed, Fatima Abubakar, Abigail Ebi Aye. Synthesis, Characterization and Antifungal Activity of Manganese (II) Complex with Schiff Base Derived from Acetylacetone and Leucine. Am J Nano Res Appl. 2017;5(6):110-113. doi: 10.11648/j.nano.20170506.15

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@article{10.11648/j.nano.20170506.15,
  author = {Aishatu Salihu Mohammed and Fatima Abubakar and Abigail Ebi Aye},
  title = {Synthesis, Characterization and Antifungal Activity of Manganese (II) Complex with Schiff Base Derived from Acetylacetone and Leucine},
  journal = {American Journal of Nano Research and Applications},
  volume = {5},
  number = {6},
  pages = {110-113},
  doi = {10.11648/j.nano.20170506.15},
  url = {https://doi.org/10.11648/j.nano.20170506.15},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.nano.20170506.15},
  abstract = {This study was aimed at synthesizing, characterizing and evaluating the antifungal activity of the Schiff base and Mn (II) complex. The reaction of the mixture of ethanol solution of acetylacetone and leucine yielded a Schiff base. The interaction between the Schiff base in hot aqueous methanol mixture and manganese (II) chloride in ethanol gave the manganese (II) Schiff base complex. The complex was characterized by decomposition/melting point temperatures, solubility test, IR spectrophotometry, colour determination, dissociation constant of Schiff base and antifungal activity. The Schiff base obtained has yellow colour, with a melting point of 250°C and percentage yield of 54.67% while the manganese (II) complex obtained had a pink colour with decomposition temperature of 167°C and percentage yield of 76.40%. The Schiff base and the complex was soluble in some solvents but slightly soluble in others. The Infrared spectra of the Schiff base showed a band at a range of 1600cm-1 - 1622cm-1 attributed to v (C=N) stretching frequencies establishing it being a Schiff base. Similar bands were observed in the spectra of Manganese (II) Schiff base complex but in lower frequencies indicating that the Schiff base has coordinated to the Mn ion. The antifungal activity of manganese (II) complex showed significant activity on the fungal isolates Candida albican and Sacchromyces cerevisiae. The study concludes that Schiff base synthesized was a weak acid and the Schiff base was not an active drug against the fungal pathogens used but Mn (II) complex was active against the pathogens used.},
 year = {2017}
}

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TY  - JOUR
T1  - Synthesis, Characterization and Antifungal Activity of Manganese (II) Complex with Schiff Base Derived from Acetylacetone and Leucine
AU  - Aishatu Salihu Mohammed
AU  - Fatima Abubakar
AU  - Abigail Ebi Aye
Y1  - 2017/12/22
PY  - 2017
N1  - https://doi.org/10.11648/j.nano.20170506.15
DO  - 10.11648/j.nano.20170506.15
T2  - American Journal of Nano Research and Applications
JF  - American Journal of Nano Research and Applications
JO  - American Journal of Nano Research and Applications
SP  - 110
EP  - 113
PB  - Science Publishing Group
SN  - 2575-3738
UR  - https://doi.org/10.11648/j.nano.20170506.15
AB  - This study was aimed at synthesizing, characterizing and evaluating the antifungal activity of the Schiff base and Mn (II) complex. The reaction of the mixture of ethanol solution of acetylacetone and leucine yielded a Schiff base. The interaction between the Schiff base in hot aqueous methanol mixture and manganese (II) chloride in ethanol gave the manganese (II) Schiff base complex. The complex was characterized by decomposition/melting point temperatures, solubility test, IR spectrophotometry, colour determination, dissociation constant of Schiff base and antifungal activity. The Schiff base obtained has yellow colour, with a melting point of 250°C and percentage yield of 54.67% while the manganese (II) complex obtained had a pink colour with decomposition temperature of 167°C and percentage yield of 76.40%. The Schiff base and the complex was soluble in some solvents but slightly soluble in others. The Infrared spectra of the Schiff base showed a band at a range of 1600cm-1 - 1622cm-1 attributed to v (C=N) stretching frequencies establishing it being a Schiff base. Similar bands were observed in the spectra of Manganese (II) Schiff base complex but in lower frequencies indicating that the Schiff base has coordinated to the Mn ion. The antifungal activity of manganese (II) complex showed significant activity on the fungal isolates Candida albican and Sacchromyces cerevisiae. The study concludes that Schiff base synthesized was a weak acid and the Schiff base was not an active drug against the fungal pathogens used but Mn (II) complex was active against the pathogens used.
VL  - 5
IS  - 6
ER  -

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Author Information

Aishatu Salihu Mohammed

Department of Applied Science, Kaduna Polytechnic, Kaduna, Nigeria
Fatima Abubakar

Department of Applied Science, Kaduna Polytechnic, Kaduna, Nigeria
Abigail Ebi Aye

Department of Applied Science, Kaduna Polytechnic, Kaduna, Nigeria

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APA Style

Aishatu Salihu Mohammed, Fatima Abubakar, Abigail Ebi Aye. (2017). Synthesis, Characterization and Antifungal Activity of Manganese (II) Complex with Schiff Base Derived from Acetylacetone and Leucine. American Journal of Nano Research and Applications, 5(6), 110-113. https://doi.org/10.11648/j.nano.20170506.15

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ACS Style

Aishatu Salihu Mohammed; Fatima Abubakar; Abigail Ebi Aye. Synthesis, Characterization and Antifungal Activity of Manganese (II) Complex with Schiff Base Derived from Acetylacetone and Leucine. Am. J. Nano Res. Appl. 2017, 5(6), 110-113. doi: 10.11648/j.nano.20170506.15

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AMA Style

Aishatu Salihu Mohammed, Fatima Abubakar, Abigail Ebi Aye. Synthesis, Characterization and Antifungal Activity of Manganese (II) Complex with Schiff Base Derived from Acetylacetone and Leucine. Am J Nano Res Appl. 2017;5(6):110-113. doi: 10.11648/j.nano.20170506.15

Copy | Download

@article{10.11648/j.nano.20170506.15,
  author = {Aishatu Salihu Mohammed and Fatima Abubakar and Abigail Ebi Aye},
  title = {Synthesis, Characterization and Antifungal Activity of Manganese (II) Complex with Schiff Base Derived from Acetylacetone and Leucine},
  journal = {American Journal of Nano Research and Applications},
  volume = {5},
  number = {6},
  pages = {110-113},
  doi = {10.11648/j.nano.20170506.15},
  url = {https://doi.org/10.11648/j.nano.20170506.15},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.nano.20170506.15},
  abstract = {This study was aimed at synthesizing, characterizing and evaluating the antifungal activity of the Schiff base and Mn (II) complex. The reaction of the mixture of ethanol solution of acetylacetone and leucine yielded a Schiff base. The interaction between the Schiff base in hot aqueous methanol mixture and manganese (II) chloride in ethanol gave the manganese (II) Schiff base complex. The complex was characterized by decomposition/melting point temperatures, solubility test, IR spectrophotometry, colour determination, dissociation constant of Schiff base and antifungal activity. The Schiff base obtained has yellow colour, with a melting point of 250°C and percentage yield of 54.67% while the manganese (II) complex obtained had a pink colour with decomposition temperature of 167°C and percentage yield of 76.40%. The Schiff base and the complex was soluble in some solvents but slightly soluble in others. The Infrared spectra of the Schiff base showed a band at a range of 1600cm-1 - 1622cm-1 attributed to v (C=N) stretching frequencies establishing it being a Schiff base. Similar bands were observed in the spectra of Manganese (II) Schiff base complex but in lower frequencies indicating that the Schiff base has coordinated to the Mn ion. The antifungal activity of manganese (II) complex showed significant activity on the fungal isolates Candida albican and Sacchromyces cerevisiae. The study concludes that Schiff base synthesized was a weak acid and the Schiff base was not an active drug against the fungal pathogens used but Mn (II) complex was active against the pathogens used.},
 year = {2017}
}

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TY  - JOUR
T1  - Synthesis, Characterization and Antifungal Activity of Manganese (II) Complex with Schiff Base Derived from Acetylacetone and Leucine
AU  - Aishatu Salihu Mohammed
AU  - Fatima Abubakar
AU  - Abigail Ebi Aye
Y1  - 2017/12/22
PY  - 2017
N1  - https://doi.org/10.11648/j.nano.20170506.15
DO  - 10.11648/j.nano.20170506.15
T2  - American Journal of Nano Research and Applications
JF  - American Journal of Nano Research and Applications
JO  - American Journal of Nano Research and Applications
SP  - 110
EP  - 113
PB  - Science Publishing Group
SN  - 2575-3738
UR  - https://doi.org/10.11648/j.nano.20170506.15
AB  - This study was aimed at synthesizing, characterizing and evaluating the antifungal activity of the Schiff base and Mn (II) complex. The reaction of the mixture of ethanol solution of acetylacetone and leucine yielded a Schiff base. The interaction between the Schiff base in hot aqueous methanol mixture and manganese (II) chloride in ethanol gave the manganese (II) Schiff base complex. The complex was characterized by decomposition/melting point temperatures, solubility test, IR spectrophotometry, colour determination, dissociation constant of Schiff base and antifungal activity. The Schiff base obtained has yellow colour, with a melting point of 250°C and percentage yield of 54.67% while the manganese (II) complex obtained had a pink colour with decomposition temperature of 167°C and percentage yield of 76.40%. The Schiff base and the complex was soluble in some solvents but slightly soluble in others. The Infrared spectra of the Schiff base showed a band at a range of 1600cm-1 - 1622cm-1 attributed to v (C=N) stretching frequencies establishing it being a Schiff base. Similar bands were observed in the spectra of Manganese (II) Schiff base complex but in lower frequencies indicating that the Schiff base has coordinated to the Mn ion. The antifungal activity of manganese (II) complex showed significant activity on the fungal isolates Candida albican and Sacchromyces cerevisiae. The study concludes that Schiff base synthesized was a weak acid and the Schiff base was not an active drug against the fungal pathogens used but Mn (II) complex was active against the pathogens used.
VL  - 5
IS  - 6
ER  -

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