Metal-based Antimicrobial Agents: Synthesis, Characterization and Biological Studies of Mannich Base Derivatives of Benzimidazole and Their Metal Complexes

Misbah ur Rehman; Muhammad Imran; Muhammad Arif; Muhammad Farooq

doi:doi:10.11648/j.sjc.20130105.12

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Metal-based Antimicrobial Agents: Synthesis, Characterization and Biological Studies of Mannich Base Derivatives of Benzimidazole and Their Metal Complexes

Misbah ur Rehman, Muhammad Imran, Muhammad Arif, Muhammad Farooq

Published in Science Journal of Chemistry (Volume 1, Issue 5)

Received: 28 October 2013 Published: 20 November 2013

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Abstract

Novel Mannich base derivatives of Benzimidazole were prepared through the condensation reaction of benzimidazole derivative with formaldehyde and primary and/ secondary amine. Zinc(II), copper(II), nickel(II) and cobalt(II) complexes of Mannich bases have also been synthesized. All the compounds were fully characterized by, elemental analyses, magnetic moment determination, molar conductivity measurement, thermogravimetric analysis, spectral and analytical data. Experimental results showed that metal complexes act as bi-dentate ligands towards divalent metal ions via azomethine-N and deprotonated-O while suggesting an octahedral geometry. All the compounds were screened for in-vitro antibacterial and antifungal activity against various bacterial and fungal strains. Almost all the compounds showed good potent activity against microorganisms. It was also seen that compounds with complexed form were more active as compared to un-complexed form. The prepared compounds were also screened for their cytotoxicity and results showed that only Ni(II) complexes exhibit some cytotoxicity while all other compounds were almost inactive.

Published in	Science Journal of Chemistry (Volume 1, Issue 5)
DOI	10.11648/j.sjc.20130105.12
Page(s)	56-66
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2013. Published by Science Publishing Group

Keywords

Mannich Bases, Benzimidazole, Metal Complexes, Biological Activity, Cytotoxicity

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APA Style

Misbah ur Rehman, Muhammad Imran, Muhammad Arif, Muhammad Farooq. (2013). Metal-based Antimicrobial Agents: Synthesis, Characterization and Biological Studies of Mannich Base Derivatives of Benzimidazole and Their Metal Complexes. Science Journal of Chemistry, 1(5), 56-66. https://doi.org/10.11648/j.sjc.20130105.12

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ACS Style

Misbah ur Rehman; Muhammad Imran; Muhammad Arif; Muhammad Farooq. Metal-based Antimicrobial Agents: Synthesis, Characterization and Biological Studies of Mannich Base Derivatives of Benzimidazole and Their Metal Complexes. Sci. J. Chem. 2013, 1(5), 56-66. doi: 10.11648/j.sjc.20130105.12

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AMA Style

Misbah ur Rehman, Muhammad Imran, Muhammad Arif, Muhammad Farooq. Metal-based Antimicrobial Agents: Synthesis, Characterization and Biological Studies of Mannich Base Derivatives of Benzimidazole and Their Metal Complexes. Sci J Chem. 2013;1(5):56-66. doi: 10.11648/j.sjc.20130105.12

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@article{10.11648/j.sjc.20130105.12,
  author = {Misbah ur Rehman and Muhammad Imran and Muhammad Arif and Muhammad Farooq},
  title = {Metal-based Antimicrobial Agents: Synthesis, Characterization and Biological Studies of Mannich Base Derivatives of Benzimidazole and Their Metal Complexes},
  journal = {Science Journal of Chemistry},
  volume = {1},
  number = {5},
  pages = {56-66},
  doi = {10.11648/j.sjc.20130105.12},
  url = {https://doi.org/10.11648/j.sjc.20130105.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.sjc.20130105.12},
  abstract = {Novel Mannich base derivatives of Benzimidazole were prepared through the condensation reaction of benzimidazole derivative with formaldehyde and primary and/ secondary amine. Zinc(II), copper(II), nickel(II) and cobalt(II) complexes of Mannich bases have also been synthesized. All the compounds were fully characterized by, elemental analyses, magnetic moment determination, molar conductivity measurement, thermogravimetric analysis, spectral and analytical data. Experimental results showed that metal complexes act as bi-dentate ligands towards divalent metal ions via azomethine-N and deprotonated-O while suggesting an octahedral geometry. All the compounds were screened for in-vitro antibacterial and antifungal activity against various bacterial and fungal strains. Almost all the compounds showed good potent activity against microorganisms. It was also seen that compounds with complexed form were more active as compared to un-complexed form. The prepared compounds were also screened for their cytotoxicity and results showed that only Ni(II) complexes exhibit some cytotoxicity while all other compounds were almost inactive.},
 year = {2013}
}

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TY  - JOUR
T1  - Metal-based Antimicrobial Agents: Synthesis, Characterization and Biological Studies of Mannich Base Derivatives of Benzimidazole and Their Metal Complexes
AU  - Misbah ur Rehman
AU  - Muhammad Imran
AU  - Muhammad Arif
AU  - Muhammad Farooq
Y1  - 2013/11/20
PY  - 2013
N1  - https://doi.org/10.11648/j.sjc.20130105.12
DO  - 10.11648/j.sjc.20130105.12
T2  - Science Journal of Chemistry
JF  - Science Journal of Chemistry
JO  - Science Journal of Chemistry
SP  - 56
EP  - 66
PB  - Science Publishing Group
SN  - 2330-099X
UR  - https://doi.org/10.11648/j.sjc.20130105.12
AB  - Novel Mannich base derivatives of Benzimidazole were prepared through the condensation reaction of benzimidazole derivative with formaldehyde and primary and/ secondary amine. Zinc(II), copper(II), nickel(II) and cobalt(II) complexes of Mannich bases have also been synthesized. All the compounds were fully characterized by, elemental analyses, magnetic moment determination, molar conductivity measurement, thermogravimetric analysis, spectral and analytical data. Experimental results showed that metal complexes act as bi-dentate ligands towards divalent metal ions via azomethine-N and deprotonated-O while suggesting an octahedral geometry. All the compounds were screened for in-vitro antibacterial and antifungal activity against various bacterial and fungal strains. Almost all the compounds showed good potent activity against microorganisms. It was also seen that compounds with complexed form were more active as compared to un-complexed form. The prepared compounds were also screened for their cytotoxicity and results showed that only Ni(II) complexes exhibit some cytotoxicity while all other compounds were almost inactive.
VL  - 1
IS  - 5
ER  -

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Author Information

Misbah ur Rehman

Institute of Chemical Sciences, Gomal University, D. I. Khan, KPK, Pakistan
Muhammad Imran

Institute of Chemical Sciences, Bahauddin Zakariya University, Multan, Pakistan
Muhammad Arif

Institute of Chemical Sciences, Bahauddin Zakariya University, Multan, Pakistan
Muhammad Farooq

Department of Chemistry, Govt. College, Gujranwala, Pakistan

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Plain Text BibTeX RIS

APA Style

Misbah ur Rehman, Muhammad Imran, Muhammad Arif, Muhammad Farooq. (2013). Metal-based Antimicrobial Agents: Synthesis, Characterization and Biological Studies of Mannich Base Derivatives of Benzimidazole and Their Metal Complexes. Science Journal of Chemistry, 1(5), 56-66. https://doi.org/10.11648/j.sjc.20130105.12

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ACS Style

Misbah ur Rehman; Muhammad Imran; Muhammad Arif; Muhammad Farooq. Metal-based Antimicrobial Agents: Synthesis, Characterization and Biological Studies of Mannich Base Derivatives of Benzimidazole and Their Metal Complexes. Sci. J. Chem. 2013, 1(5), 56-66. doi: 10.11648/j.sjc.20130105.12

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AMA Style

Misbah ur Rehman, Muhammad Imran, Muhammad Arif, Muhammad Farooq. Metal-based Antimicrobial Agents: Synthesis, Characterization and Biological Studies of Mannich Base Derivatives of Benzimidazole and Their Metal Complexes. Sci J Chem. 2013;1(5):56-66. doi: 10.11648/j.sjc.20130105.12

Copy | Download

@article{10.11648/j.sjc.20130105.12,
  author = {Misbah ur Rehman and Muhammad Imran and Muhammad Arif and Muhammad Farooq},
  title = {Metal-based Antimicrobial Agents: Synthesis, Characterization and Biological Studies of Mannich Base Derivatives of Benzimidazole and Their Metal Complexes},
  journal = {Science Journal of Chemistry},
  volume = {1},
  number = {5},
  pages = {56-66},
  doi = {10.11648/j.sjc.20130105.12},
  url = {https://doi.org/10.11648/j.sjc.20130105.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.sjc.20130105.12},
  abstract = {Novel Mannich base derivatives of Benzimidazole were prepared through the condensation reaction of benzimidazole derivative with formaldehyde and primary and/ secondary amine. Zinc(II), copper(II), nickel(II) and cobalt(II) complexes of Mannich bases have also been synthesized. All the compounds were fully characterized by, elemental analyses, magnetic moment determination, molar conductivity measurement, thermogravimetric analysis, spectral and analytical data. Experimental results showed that metal complexes act as bi-dentate ligands towards divalent metal ions via azomethine-N and deprotonated-O while suggesting an octahedral geometry. All the compounds were screened for in-vitro antibacterial and antifungal activity against various bacterial and fungal strains. Almost all the compounds showed good potent activity against microorganisms. It was also seen that compounds with complexed form were more active as compared to un-complexed form. The prepared compounds were also screened for their cytotoxicity and results showed that only Ni(II) complexes exhibit some cytotoxicity while all other compounds were almost inactive.},
 year = {2013}
}

Copy | Download

TY  - JOUR
T1  - Metal-based Antimicrobial Agents: Synthesis, Characterization and Biological Studies of Mannich Base Derivatives of Benzimidazole and Their Metal Complexes
AU  - Misbah ur Rehman
AU  - Muhammad Imran
AU  - Muhammad Arif
AU  - Muhammad Farooq
Y1  - 2013/11/20
PY  - 2013
N1  - https://doi.org/10.11648/j.sjc.20130105.12
DO  - 10.11648/j.sjc.20130105.12
T2  - Science Journal of Chemistry
JF  - Science Journal of Chemistry
JO  - Science Journal of Chemistry
SP  - 56
EP  - 66
PB  - Science Publishing Group
SN  - 2330-099X
UR  - https://doi.org/10.11648/j.sjc.20130105.12
AB  - Novel Mannich base derivatives of Benzimidazole were prepared through the condensation reaction of benzimidazole derivative with formaldehyde and primary and/ secondary amine. Zinc(II), copper(II), nickel(II) and cobalt(II) complexes of Mannich bases have also been synthesized. All the compounds were fully characterized by, elemental analyses, magnetic moment determination, molar conductivity measurement, thermogravimetric analysis, spectral and analytical data. Experimental results showed that metal complexes act as bi-dentate ligands towards divalent metal ions via azomethine-N and deprotonated-O while suggesting an octahedral geometry. All the compounds were screened for in-vitro antibacterial and antifungal activity against various bacterial and fungal strains. Almost all the compounds showed good potent activity against microorganisms. It was also seen that compounds with complexed form were more active as compared to un-complexed form. The prepared compounds were also screened for their cytotoxicity and results showed that only Ni(II) complexes exhibit some cytotoxicity while all other compounds were almost inactive.
VL  - 1
IS  - 5
ER  -

Copy | Download