Mechanisms of Microbial Resistance to Known Antibiotics

Ahamefule Augustus Kelechi; Ezeji Ethelbert Uchechukwu

doi:doi:10.11648/j.sjph.s.2015030501.14

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Mechanisms of Microbial Resistance to Known Antibiotics

Ahamefule Augustus Kelechi, Ezeji Ethelbert Uchechukwu

Published in Science Journal of Public Health (Volume 3, Issue 5-1)

Received: 24 May 2015 Accepted: 26 June 2015 Published: 8 September 2015

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Abstract

Most infectious diseases are known to be caused by microorganisms. The discovery of antimicrobial agents has saved the human race from a lot of sufferings due to the burden of these infectious diseases. Over the years, microorganisms have developed resistance to known antibiotics. Antimicrobial resistance among bacteria, viruses, parasites, and other disease-causing organisms is a serious threat to infectious disease management globally. Factors responsible for antimicrobial resistance include changing microbial characteristics, selective pressures of antimicrobial use, as well as societal and technological changes that enhance the development and transmission of drug-resistant organisms. Microbial resistance to antibiotics can either be intrinsic or acquired. Different mechanisms of microbial resistance to known antibiotics have been proposed. These include antibiotic inactivation, ribosome protection, biofilm formation, target modification, reduced permeability to antimicrobial agents and increasing efflux of antibiotics from microbial cells. It is believed that the understanding of these mechanisms is important in the discovery of better ways to keep existing agents useful and also in the design of better antimicrobial agents that are not affected by the currently known, predicted, or unknown mechanisms of resistance.

Published in	Science Journal of Public Health (Volume 3, Issue 5-1) This article belongs to the Special Issue Who Is Afraid of the Microbes
DOI	10.11648/j.sjph.s.2015030501.14
Page(s)	20-24
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2015. Published by Science Publishing Group

Keywords

Antimicrobial Agents, Diseases, Chemotherapy, Resistance, Microorganisms

References

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APA Style

Ahamefule Augustus Kelechi, Ezeji Ethelbert Uchechukwu. (2015). Mechanisms of Microbial Resistance to Known Antibiotics. Science Journal of Public Health, 3(5-1), 20-24. https://doi.org/10.11648/j.sjph.s.2015030501.14

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ACS Style

Ahamefule Augustus Kelechi; Ezeji Ethelbert Uchechukwu. Mechanisms of Microbial Resistance to Known Antibiotics. Sci. J. Public Health 2015, 3(5-1), 20-24. doi: 10.11648/j.sjph.s.2015030501.14

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AMA Style

Ahamefule Augustus Kelechi, Ezeji Ethelbert Uchechukwu. Mechanisms of Microbial Resistance to Known Antibiotics. Sci J Public Health. 2015;3(5-1):20-24. doi: 10.11648/j.sjph.s.2015030501.14

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@article{10.11648/j.sjph.s.2015030501.14,
  author = {Ahamefule Augustus Kelechi and Ezeji Ethelbert Uchechukwu},
  title = {Mechanisms of Microbial Resistance to Known Antibiotics},
  journal = {Science Journal of Public Health},
  volume = {3},
  number = {5-1},
  pages = {20-24},
  doi = {10.11648/j.sjph.s.2015030501.14},
  url = {https://doi.org/10.11648/j.sjph.s.2015030501.14},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.sjph.s.2015030501.14},
  abstract = {Most infectious diseases are known to be caused by microorganisms. The discovery of antimicrobial agents has saved the human race from a lot of sufferings due to the burden of these infectious diseases. Over the years, microorganisms have developed resistance to known antibiotics. Antimicrobial resistance among bacteria, viruses, parasites, and other disease-causing organisms is a serious threat to infectious disease management globally. Factors responsible for antimicrobial resistance include changing microbial characteristics, selective pressures of antimicrobial use, as well as societal and technological changes that enhance the development and transmission of drug-resistant organisms. Microbial resistance to antibiotics can either be intrinsic or acquired. Different mechanisms of microbial resistance to known antibiotics have been proposed. These include antibiotic inactivation, ribosome protection, biofilm formation, target modification, reduced permeability to antimicrobial agents and increasing efflux of antibiotics from microbial cells. It is believed that the understanding of these mechanisms is important in the discovery of better ways to keep existing agents useful and also in the design of better antimicrobial agents that are not affected by the currently known, predicted, or unknown mechanisms of resistance.},
 year = {2015}
}

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TY  - JOUR
T1  - Mechanisms of Microbial Resistance to Known Antibiotics
AU  - Ahamefule Augustus Kelechi
AU  - Ezeji Ethelbert Uchechukwu
Y1  - 2015/09/08
PY  - 2015
N1  - https://doi.org/10.11648/j.sjph.s.2015030501.14
DO  - 10.11648/j.sjph.s.2015030501.14
T2  - Science Journal of Public Health
JF  - Science Journal of Public Health
JO  - Science Journal of Public Health
SP  - 20
EP  - 24
PB  - Science Publishing Group
SN  - 2328-7950
UR  - https://doi.org/10.11648/j.sjph.s.2015030501.14
AB  - Most infectious diseases are known to be caused by microorganisms. The discovery of antimicrobial agents has saved the human race from a lot of sufferings due to the burden of these infectious diseases. Over the years, microorganisms have developed resistance to known antibiotics. Antimicrobial resistance among bacteria, viruses, parasites, and other disease-causing organisms is a serious threat to infectious disease management globally. Factors responsible for antimicrobial resistance include changing microbial characteristics, selective pressures of antimicrobial use, as well as societal and technological changes that enhance the development and transmission of drug-resistant organisms. Microbial resistance to antibiotics can either be intrinsic or acquired. Different mechanisms of microbial resistance to known antibiotics have been proposed. These include antibiotic inactivation, ribosome protection, biofilm formation, target modification, reduced permeability to antimicrobial agents and increasing efflux of antibiotics from microbial cells. It is believed that the understanding of these mechanisms is important in the discovery of better ways to keep existing agents useful and also in the design of better antimicrobial agents that are not affected by the currently known, predicted, or unknown mechanisms of resistance.
VL  - 3
IS  - 5-1
ER  -

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Author Information

Ahamefule Augustus Kelechi

Department of Biotechnology, Federal University of Technology, Owerri, Nigeria
Ezeji Ethelbert Uchechukwu

Department of Biotechnology, Federal University of Technology, Owerri, Nigeria

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Plain Text BibTeX RIS

APA Style

Ahamefule Augustus Kelechi, Ezeji Ethelbert Uchechukwu. (2015). Mechanisms of Microbial Resistance to Known Antibiotics. Science Journal of Public Health, 3(5-1), 20-24. https://doi.org/10.11648/j.sjph.s.2015030501.14

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ACS Style

Ahamefule Augustus Kelechi; Ezeji Ethelbert Uchechukwu. Mechanisms of Microbial Resistance to Known Antibiotics. Sci. J. Public Health 2015, 3(5-1), 20-24. doi: 10.11648/j.sjph.s.2015030501.14

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AMA Style

Ahamefule Augustus Kelechi, Ezeji Ethelbert Uchechukwu. Mechanisms of Microbial Resistance to Known Antibiotics. Sci J Public Health. 2015;3(5-1):20-24. doi: 10.11648/j.sjph.s.2015030501.14

Copy | Download

@article{10.11648/j.sjph.s.2015030501.14,
  author = {Ahamefule Augustus Kelechi and Ezeji Ethelbert Uchechukwu},
  title = {Mechanisms of Microbial Resistance to Known Antibiotics},
  journal = {Science Journal of Public Health},
  volume = {3},
  number = {5-1},
  pages = {20-24},
  doi = {10.11648/j.sjph.s.2015030501.14},
  url = {https://doi.org/10.11648/j.sjph.s.2015030501.14},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.sjph.s.2015030501.14},
  abstract = {Most infectious diseases are known to be caused by microorganisms. The discovery of antimicrobial agents has saved the human race from a lot of sufferings due to the burden of these infectious diseases. Over the years, microorganisms have developed resistance to known antibiotics. Antimicrobial resistance among bacteria, viruses, parasites, and other disease-causing organisms is a serious threat to infectious disease management globally. Factors responsible for antimicrobial resistance include changing microbial characteristics, selective pressures of antimicrobial use, as well as societal and technological changes that enhance the development and transmission of drug-resistant organisms. Microbial resistance to antibiotics can either be intrinsic or acquired. Different mechanisms of microbial resistance to known antibiotics have been proposed. These include antibiotic inactivation, ribosome protection, biofilm formation, target modification, reduced permeability to antimicrobial agents and increasing efflux of antibiotics from microbial cells. It is believed that the understanding of these mechanisms is important in the discovery of better ways to keep existing agents useful and also in the design of better antimicrobial agents that are not affected by the currently known, predicted, or unknown mechanisms of resistance.},
 year = {2015}
}

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TY  - JOUR
T1  - Mechanisms of Microbial Resistance to Known Antibiotics
AU  - Ahamefule Augustus Kelechi
AU  - Ezeji Ethelbert Uchechukwu
Y1  - 2015/09/08
PY  - 2015
N1  - https://doi.org/10.11648/j.sjph.s.2015030501.14
DO  - 10.11648/j.sjph.s.2015030501.14
T2  - Science Journal of Public Health
JF  - Science Journal of Public Health
JO  - Science Journal of Public Health
SP  - 20
EP  - 24
PB  - Science Publishing Group
SN  - 2328-7950
UR  - https://doi.org/10.11648/j.sjph.s.2015030501.14
AB  - Most infectious diseases are known to be caused by microorganisms. The discovery of antimicrobial agents has saved the human race from a lot of sufferings due to the burden of these infectious diseases. Over the years, microorganisms have developed resistance to known antibiotics. Antimicrobial resistance among bacteria, viruses, parasites, and other disease-causing organisms is a serious threat to infectious disease management globally. Factors responsible for antimicrobial resistance include changing microbial characteristics, selective pressures of antimicrobial use, as well as societal and technological changes that enhance the development and transmission of drug-resistant organisms. Microbial resistance to antibiotics can either be intrinsic or acquired. Different mechanisms of microbial resistance to known antibiotics have been proposed. These include antibiotic inactivation, ribosome protection, biofilm formation, target modification, reduced permeability to antimicrobial agents and increasing efflux of antibiotics from microbial cells. It is believed that the understanding of these mechanisms is important in the discovery of better ways to keep existing agents useful and also in the design of better antimicrobial agents that are not affected by the currently known, predicted, or unknown mechanisms of resistance.
VL  - 3
IS  - 5-1
ER  -

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