Antioxidants help to mop up free radicals that serious damage to the body system and hence are referred to as free radical scavengers. The main objective of this study was to assess the antioxidant property of ethanol seed extract of Picralima nitida in malaria-induce mice. The activities of the antioxidant enzymes myeloperoxidase (MPO), superoxide dismutase (SOD), thioredoxin reductase (TrxR) were assayed; malondialdehyde (MDA) and nitrite levels were determined. The levels of nitrite and MDA and the SOD activity of the drug-treated groups of mice were significantly (p < 0.05) lower on days 3 and 5 post treatment compared to the group induced with malaria but not treated (positive control). The MPO activity of the drug-treated groups of mice was significantly (p < 0.05) higher on day 3 post treatment while its activity in mice treated with 40 and 80 mg/kg b.w. of the extract were significantly (p < 0.05) lower on day 5 post treatment compared to the positive control. In the group treated with 80 mg/kg b.w. of the extract, the TrxR activity was significantly (p < 0.05) lower on days 3 and 5 post treatment compared to the positive control. Picralima nitida seed extract was found to possess good antioxidant properties.
| Published in | American Journal of Life Sciences (Volume 5, Issue 5) |
| DOI | 10.11648/j.ajls.20170505.12 |
| Page(s) | 125-133 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2017. Published by Science Publishing Group |
Antioxidants, Free Radicals, SOD, MDA, TrxR
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APA Style
Nwankwo Nicodemus E., Nwodo Fred O. C., Joshua Parker E. (2017). Free Radical Scavenging Property of Picralima nitida Seed Extract on Malaria-Induced Albino Mice. American Journal of Life Sciences, 5(5), 125-133. https://doi.org/10.11648/j.ajls.20170505.12
ACS Style
Nwankwo Nicodemus E.; Nwodo Fred O. C.; Joshua Parker E. Free Radical Scavenging Property of Picralima nitida Seed Extract on Malaria-Induced Albino Mice. Am. J. Life Sci. 2017, 5(5), 125-133. doi: 10.11648/j.ajls.20170505.12
AMA Style
Nwankwo Nicodemus E., Nwodo Fred O. C., Joshua Parker E. Free Radical Scavenging Property of Picralima nitida Seed Extract on Malaria-Induced Albino Mice. Am J Life Sci. 2017;5(5):125-133. doi: 10.11648/j.ajls.20170505.12
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Download@article{10.11648/j.ajls.20170505.12,
author = {Nwankwo Nicodemus E. and Nwodo Fred O. C. and Joshua Parker E.},
title = {Free Radical Scavenging Property of Picralima nitida Seed Extract on Malaria-Induced Albino Mice},
journal = {American Journal of Life Sciences},
volume = {5},
number = {5},
pages = {125-133},
doi = {10.11648/j.ajls.20170505.12},
url = {https://doi.org/10.11648/j.ajls.20170505.12},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajls.20170505.12},
abstract = {Antioxidants help to mop up free radicals that serious damage to the body system and hence are referred to as free radical scavengers. The main objective of this study was to assess the antioxidant property of ethanol seed extract of Picralima nitida in malaria-induce mice. The activities of the antioxidant enzymes myeloperoxidase (MPO), superoxide dismutase (SOD), thioredoxin reductase (TrxR) were assayed; malondialdehyde (MDA) and nitrite levels were determined. The levels of nitrite and MDA and the SOD activity of the drug-treated groups of mice were significantly (p < 0.05) lower on days 3 and 5 post treatment compared to the group induced with malaria but not treated (positive control). The MPO activity of the drug-treated groups of mice was significantly (p Picralima nitida seed extract was found to possess good antioxidant properties.},
year = {2017}
}
TY - JOUR T1 - Free Radical Scavenging Property of Picralima nitida Seed Extract on Malaria-Induced Albino Mice AU - Nwankwo Nicodemus E. AU - Nwodo Fred O. C. AU - Joshua Parker E. Y1 - 2017/09/21 PY - 2017 N1 - https://doi.org/10.11648/j.ajls.20170505.12 DO - 10.11648/j.ajls.20170505.12 T2 - American Journal of Life Sciences JF - American Journal of Life Sciences JO - American Journal of Life Sciences SP - 125 EP - 133 PB - Science Publishing Group SN - 2328-5737 UR - https://doi.org/10.11648/j.ajls.20170505.12 AB - Antioxidants help to mop up free radicals that serious damage to the body system and hence are referred to as free radical scavengers. The main objective of this study was to assess the antioxidant property of ethanol seed extract of Picralima nitida in malaria-induce mice. The activities of the antioxidant enzymes myeloperoxidase (MPO), superoxide dismutase (SOD), thioredoxin reductase (TrxR) were assayed; malondialdehyde (MDA) and nitrite levels were determined. The levels of nitrite and MDA and the SOD activity of the drug-treated groups of mice were significantly (p < 0.05) lower on days 3 and 5 post treatment compared to the group induced with malaria but not treated (positive control). The MPO activity of the drug-treated groups of mice was significantly (p Picralima nitida seed extract was found to possess good antioxidant properties. VL - 5 IS - 5 ER -
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